Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth

Introduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental hemodynamics has not been studied. We aimed to evaluate associations betwe...

Full description

Bibliographic Details
Authors: Knox, B, Güil-Oumrait, N, Basagaña, X, Cserbik, D, Dadvand, P, Foraster, M, Galmes, T, Gascon, M, Gomez-Roig, MD, Gomez-Herrera, L, Haug, LS, Llurba, E, Márquez, S, Rivas, I, Sunyer, J, Thomsen, C, Zanini, MJ, Bustamante, M, Vrijheid, M
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p18630
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18630
http://ddd.uab.cat/record/309300
Access Level:Open access
Keyword:PFAS
Fetal growth
Placenta
Mixtures
id ES_6539fae563c19fa90b6b012056ecf44b
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p18630
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growthKnox, BGüil-Oumrait, NBasagaña, XCserbik, DDadvand, PForaster, MGalmes, TGascon, MGomez-Roig, MDGomez-Herrera, LHaug, LSLlurba, EMárquez, SRivas, ISunyer, JThomsen, CZanini, MJBustamante, MVrijheid, MPFASFetal growthPlacentaMixturesIntroduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental hemodynamics has not been studied. We aimed to evaluate associations between prenatal PFAS exposure and fetal growth and fetoplacental hemodynamics. Methods: We included 747 pregnant women from the BiSC birth cohort (Barcelona, Spain (2018-2021)). Twentythree PFAS were measured at 32 weeks of pregnancy in maternal plasma, of which 13 were present above detectable levels. Fetal growth was measured by ultrasound, as estimated fetal weight at 32 and 37 weeks of gestation, and weight at birth. Doppler ultrasound measurements for uterine (UtA), umbilical (UmA), and middle cerebral artery (MCA) pulsatility indices (PI), as well as the cerebroplacental ratio (CPR - ratio MCA to UmA), were obtained at 32 weeks to assess fetoplacental hemodynamics. We applied linear mixed effects models to assess the association between singular PFAS and longitudinal fetal growth and PI, and Bayesian Weighted Quantile Sum models to evaluate associations between the PFAS mixture and the aforementioned outcomes, controlled for the relevant covariates. Results: Single PFAS and the mixture tended to be associated with reduced fetal growth and CPR PI, but few associations reached statistical significance. Legacy PFAS PFOS, PFHpA, and PFDoDa were associated with statistically significant decreases in fetal weight z-score of 0.13 (95%CI (-0.22,-0.04), 0.06 (-0.10, 0.01), and 0.05 (-0.10, 0.00), respectively, per doubling of concentration. The PFAS mixture was associated with a non- statistically significant 0.09 decrease in birth weight z-score (95%CI-0.22, 0.04) per quartile increase. Conclusion: This study suggests that legacy PFAS may be associated with reduced fetal growth, but associations for next generation PFAS and for the PFAS mixture were less conclusive. Associations between PFAS and fetoplacental hemodynamics warrant further investigation.PERGAMON-ELSEVIER SCIENCE LTD2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18630http://ddd.uab.cat/record/309300ENVIRONMENT INTERNATIONALISSN: 01604120ISSNe: 18736750reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p186302026-06-14T12:41:47Z
dc.title.none.fl_str_mv Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
title Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
spellingShingle Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
Knox, B
PFAS
Fetal growth
Placenta
Mixtures
title_short Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
title_full Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
title_fullStr Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
title_full_unstemmed Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
title_sort Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
dc.creator.none.fl_str_mv Knox, B
Güil-Oumrait, N
Basagaña, X
Cserbik, D
Dadvand, P
Foraster, M
Galmes, T
Gascon, M
Gomez-Roig, MD
Gomez-Herrera, L
Haug, LS
Llurba, E
Márquez, S
Rivas, I
Sunyer, J
Thomsen, C
Zanini, MJ
Bustamante, M
Vrijheid, M
author Knox, B
author_facet Knox, B
Güil-Oumrait, N
Basagaña, X
Cserbik, D
Dadvand, P
Foraster, M
Galmes, T
Gascon, M
Gomez-Roig, MD
Gomez-Herrera, L
Haug, LS
Llurba, E
Márquez, S
Rivas, I
Sunyer, J
Thomsen, C
Zanini, MJ
Bustamante, M
Vrijheid, M
author_role author
author2 Güil-Oumrait, N
Basagaña, X
Cserbik, D
Dadvand, P
Foraster, M
Galmes, T
Gascon, M
Gomez-Roig, MD
Gomez-Herrera, L
Haug, LS
Llurba, E
Márquez, S
Rivas, I
Sunyer, J
Thomsen, C
Zanini, MJ
Bustamante, M
Vrijheid, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PFAS
Fetal growth
Placenta
Mixtures
topic PFAS
Fetal growth
Placenta
Mixtures
description Introduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental hemodynamics has not been studied. We aimed to evaluate associations between prenatal PFAS exposure and fetal growth and fetoplacental hemodynamics. Methods: We included 747 pregnant women from the BiSC birth cohort (Barcelona, Spain (2018-2021)). Twentythree PFAS were measured at 32 weeks of pregnancy in maternal plasma, of which 13 were present above detectable levels. Fetal growth was measured by ultrasound, as estimated fetal weight at 32 and 37 weeks of gestation, and weight at birth. Doppler ultrasound measurements for uterine (UtA), umbilical (UmA), and middle cerebral artery (MCA) pulsatility indices (PI), as well as the cerebroplacental ratio (CPR - ratio MCA to UmA), were obtained at 32 weeks to assess fetoplacental hemodynamics. We applied linear mixed effects models to assess the association between singular PFAS and longitudinal fetal growth and PI, and Bayesian Weighted Quantile Sum models to evaluate associations between the PFAS mixture and the aforementioned outcomes, controlled for the relevant covariates. Results: Single PFAS and the mixture tended to be associated with reduced fetal growth and CPR PI, but few associations reached statistical significance. Legacy PFAS PFOS, PFHpA, and PFDoDa were associated with statistically significant decreases in fetal weight z-score of 0.13 (95%CI (-0.22,-0.04), 0.06 (-0.10, 0.01), and 0.05 (-0.10, 0.00), respectively, per doubling of concentration. The PFAS mixture was associated with a non- statistically significant 0.09 decrease in birth weight z-score (95%CI-0.22, 0.04) per quartile increase. Conclusion: This study suggests that legacy PFAS may be associated with reduced fetal growth, but associations for next generation PFAS and for the PFAS mixture were less conclusive. Associations between PFAS and fetoplacental hemodynamics warrant further investigation.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18630
http://ddd.uab.cat/record/309300
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18630
http://ddd.uab.cat/record/309300
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv ENVIRONMENT INTERNATIONAL
ISSN: 01604120
ISSNe: 18736750
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409726599528448
score 15,812429

Similar Items