Discotic amphiphilic supramolecular polymers for drug release and cell activation with light

The limited efficacy shown by drug delivery systems so far prompts the development of new molecular approaches for releasing drugs in a controlled and selective manner. Light is a privileged stimulus for delivery because it can be applied in sharp spatiotemporal patterns and is orthogonal to most bi...

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Detalhes bibliográficos
Autores: Santini, Ramona, Fuentes, Edgar, Maleeva, Galyna, Matera, Carlo, Riefolo, Fabio, Berrocal, José Augusto, Albertazzi, Lorenzo, Gorostiza, Pau, Pujals, Silvia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/387363
Acesso em linha:http://hdl.handle.net/10261/387363
https://api.elsevier.com/content/abstract/scopus_id/105002387847
Access Level:acceso abierto
Palavra-chave:Polymers
Drug release
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Discotic amphiphilic supramolecular polymers for drug release and cell activation with lightSantini, RamonaFuentes, EdgarMaleeva, GalynaMatera, CarloRiefolo, FabioBerrocal, José AugustoAlbertazzi, LorenzoGorostiza, PauPujals, SilviaPolymersDrug releasehttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesThe limited efficacy shown by drug delivery systems so far prompts the development of new molecular approaches for releasing drugs in a controlled and selective manner. Light is a privileged stimulus for delivery because it can be applied in sharp spatiotemporal patterns and is orthogonal to most biological processes. Supramolecular polymers form molecular nanostructures whose robustness, versatility, and responsivity to different stimuli have generated wide interest in materials chemistry. However, their application as drug delivery vehicles has received little attention. We built supramolecular polymers based on discotic amphiphiles that self-assemble in linear nanostructures in water. They can integrate diverse amphiphilic bioligands and release them upon illumination, acutely producing functional effects under physiological conditions. We devised two strategies for drug incorporation into the photoswitchable nanofibers. In the co-assembly strategy, discotic monomers with and without conjugated bioligands were co-assembled in helicoidal supramolecular fibers. In the drug embedding approach, we integrated a potent agonist of muscarinic receptors into the discotic polymer by noncovalent stacking interactions. This ligand can be released on demand with light ex situ and in situ, rapidly activating the target receptor and triggering intracellular responses. These novel discotic supramolecular polymers can be light-driven drug carriers for small, planar, and amphiphilic drugs.The authors wish to thank Unai Elezcano and Sònia Varon for help with the synthesis and purification. The authors wish to thank Isabel Oliveira and David Izquierdo for the support and useful discussion. This research was funded by the EU Horizon 2020 Framework Programme for Research and Innovation, including the European Innovation Council Pathfinder (Phototheraport, 101130883), the Human Brain Project (WaveScalES, SGA3, 945539), and Information and Communication Technologies (Deeper, ICT-36-2020-101016787); by the Government of Catalonia (CERCA Programme; AGAUR 2021-SGR-01410); by the Spanish Ministry of Science and Innovation (DEEP RED, grant PID2019-111493RB-I00; EPILLUM, grant AEI/10.13039/501100011033; STROMATARGET, grant PID2019-109450RB-I00/AEI/10.13039/501100011033; Research Network in Biomedicine eBrains-Spain, RED2022-134823-E; Ramón y Cajal Investigator grant RYC2021-033056-I financed by MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR to G. M.); and by the Erasmus + Unipharma Graduates Programme to R. S.Peer reviewedRoyal Society of Chemistry (UK)European CommissionMinisterio de Ciencia e Innovación (España)0000-0002-3487-21870000-0002-1379-15210000-0001-6939-38590000-0002-6762-26190000-0003-3435-83100000-0002-6837-08120000-0002-7268-55770000-0003-1776-4296Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/387363https://api.elsevier.com/content/abstract/scopus_id/105002387847reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/101130883info:eu-repo/grantAgreement/EC/H2020/945539info:eu-repo/grantAgreement/MCIN/AEI/10.13039Nanoscalehttps://doi.org/10.1039/D4NR02957GSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3873632026-05-22T06:33:51Z
dc.title.none.fl_str_mv Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
title Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
spellingShingle Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
Santini, Ramona
Polymers
Drug release
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
title_full Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
title_fullStr Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
title_full_unstemmed Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
title_sort Discotic amphiphilic supramolecular polymers for drug release and cell activation with light
dc.creator.none.fl_str_mv Santini, Ramona
Fuentes, Edgar
Maleeva, Galyna
Matera, Carlo
Riefolo, Fabio
Berrocal, José Augusto
Albertazzi, Lorenzo
Gorostiza, Pau
Pujals, Silvia
author Santini, Ramona
author_facet Santini, Ramona
Fuentes, Edgar
Maleeva, Galyna
Matera, Carlo
Riefolo, Fabio
Berrocal, José Augusto
Albertazzi, Lorenzo
Gorostiza, Pau
Pujals, Silvia
author_role author
author2 Fuentes, Edgar
Maleeva, Galyna
Matera, Carlo
Riefolo, Fabio
Berrocal, José Augusto
Albertazzi, Lorenzo
Gorostiza, Pau
Pujals, Silvia
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia e Innovación (España)
0000-0002-3487-2187
0000-0002-1379-1521
0000-0001-6939-3859
0000-0002-6762-2619
0000-0003-3435-8310
0000-0002-6837-0812
0000-0002-7268-5577
0000-0003-1776-4296
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Polymers
Drug release
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Polymers
Drug release
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description The limited efficacy shown by drug delivery systems so far prompts the development of new molecular approaches for releasing drugs in a controlled and selective manner. Light is a privileged stimulus for delivery because it can be applied in sharp spatiotemporal patterns and is orthogonal to most biological processes. Supramolecular polymers form molecular nanostructures whose robustness, versatility, and responsivity to different stimuli have generated wide interest in materials chemistry. However, their application as drug delivery vehicles has received little attention. We built supramolecular polymers based on discotic amphiphiles that self-assemble in linear nanostructures in water. They can integrate diverse amphiphilic bioligands and release them upon illumination, acutely producing functional effects under physiological conditions. We devised two strategies for drug incorporation into the photoswitchable nanofibers. In the co-assembly strategy, discotic monomers with and without conjugated bioligands were co-assembled in helicoidal supramolecular fibers. In the drug embedding approach, we integrated a potent agonist of muscarinic receptors into the discotic polymer by noncovalent stacking interactions. This ligand can be released on demand with light ex situ and in situ, rapidly activating the target receptor and triggering intracellular responses. These novel discotic supramolecular polymers can be light-driven drug carriers for small, planar, and amphiphilic drugs.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/387363
https://api.elsevier.com/content/abstract/scopus_id/105002387847
url http://hdl.handle.net/10261/387363
https://api.elsevier.com/content/abstract/scopus_id/105002387847
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/101130883
info:eu-repo/grantAgreement/EC/H2020/945539
info:eu-repo/grantAgreement/MCIN/AEI/10.13039
Nanoscale
https://doi.org/10.1039/D4NR02957G
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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