Exploring the influence of baseline rheumatoid factor levels on TNF inhibitor retention rate in patients with rheumatoid arthritis

Objective To assess whether the retention rate of certolizumab pegol (CZP) was longer than that of other tumour necrosis factor inhibitors (TNFi) based on baseline rheumatoid factor (RF) levels. Methods Longitudinal, retrospective and multicentre study including patients with RA who were treated wit...

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Autores: López-Medina, Clementina|||0000-0002-2309-5837, Calvo-Gutiérrez, Jerusalem, Ábalos-Aguilera, M. Carmen, Cepas, Francisco, Plasencia-Rodríguez, Chamaida|||0000-0003-3503-9047, Martínez-Feito, Ana|||0000-0002-5580-8387, Balsa, Alejandro|||0000-0001-8070-7062, Faré-García, Regina, Juan-Mas, Antoni, Ruiz-Esquide, Virginia|||0000-0002-2657-6601, Sainz, Luis|||0000-0001-9249-1983, Diaz-Torne, Cesar|||0000-0001-6275-7699, Godoy-Navarrete, Francisco Javier, Añón-Oñate, Isabel, Mena-Vázquez, Natalia|||0000-0001-6173-2051, Manrique-Arija, Sara|||0000-0003-2284-7846, Moreno-García, Marina Soledad, Ortega-Castro, Rafaela, Escudero-Contreras, Alejandro
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:304080
Acceso en línea:https://ddd.uab.cat/record/304080
https://dx.doi.org/urn:doi:10.1136/rmdopen-2023-003975
Access Level:acceso abierto
Palabra clave:Antibodies, Monoclonal
Arthritis, Rheumatoid
Certolizumab Pegol
Etanercept
Humans
Retrospective Studies
Rheumatoid Factor
Treatment Outcome
Tumor Necrosis Factor Inhibitors
Descripción
Sumario:Objective To assess whether the retention rate of certolizumab pegol (CZP) was longer than that of other tumour necrosis factor inhibitors (TNFi) based on baseline rheumatoid factor (RF) levels. Methods Longitudinal, retrospective and multicentre study including patients with RA who were treated with any TNFi (monoclonal antibodies (mAB), etanercept (ETA) or CZP). Log-rank test and Cox regressions were conducted to evaluate the retention rate in the three groups according to the level of RF, with the third quartile of the baseline levels used as cutoff: <200 (<Q3) and ≥200 (≥Q3) IU/mL. A sensitivity analysis matching patients using a propensity score technique based on age, concomitant use of methotrexate and previous targeted synthetic/biological disease-modifying antirheumatic drugs was performed to address the imbalance across groups. Results A total of 638 individuals and 752 treatments (132 CZP, 439 mAB and 181 ETA) were included. In non-naïve patients with ≥200 IU/mL of RF, those treated with CZP showed a significantly longer retention rate in comparison with mAB and ETA. After matching using the propensity score, patients with ≥200 IU/mL RF levels exhibited longer retention rates with CZP than with mAB (HR 2.3 (95% CI 1.2 to 4.3), or ETA (HR 2.8 (95% CI 1.5 to 5.2). No differences were found between groups in patients with <200 UI/mL. Conclusions CZP showed a longer retention rate than mAB and ETA in patients with very high RF levels (≥200 IU/mL), while these differences were absent in patients with <200 IU/mL levels. The results suggest the potential effect of RF on binding the fragment crystallisable portion of certain TNFi.

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