Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study

Background: Epstein-Barr virus (EBV)-related malignancies harbour distinct serological responses to EBV antigens. We hypothesized that EBV serological patterns can be useful to identify different stages of chronic lymphocytic leukemia. Methods: Information on 150 cases with chronic lymphocytic leuke...

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Autores: Casabonne, Delphine, Benavente, Yolanda, Robles, Claudia, Costas, Laura, Alonso Sanz, Esther, González Barca, Eva, Tardón, Adonina, Dierssen Sotos, Trinidad, Gimeno Vázquez, Eva, Aymerich Gregorio, Marta, Campo Güerri, Elias, Castaño-Vinyals, Gemma, Aragonès Sanz, Núria, Pollán, Marina, Kogevinas, Manolis, Juwana, Hedy, Middeldorp, Jaap M., Sanjosé Llongueras, Silvia de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/125407
Acesso em linha:https://hdl.handle.net/2445/125407
Access Level:acceso abierto
Palavra-chave:Leucèmia limfocítica crònica
Virus
Chronic lymphocytic leukemia
Viruses
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spelling Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control studyCasabonne, DelphineBenavente, YolandaRobles, ClaudiaCostas, LauraAlonso Sanz, EstherGonzález Barca, EvaTardón, AdoninaDierssen Sotos, TrinidadGimeno Vázquez, EvaAymerich Gregorio, MartaCampo Güerri, EliasCastaño-Vinyals, GemmaAragonès Sanz, NúriaPollán, MarinaKogevinas, ManolisJuwana, HedyMiddeldorp, Jaap M.Sanjosé Llongueras, Silvia deLeucèmia limfocítica crònicaVirusChronic lymphocytic leukemiaVirusesBackground: Epstein-Barr virus (EBV)-related malignancies harbour distinct serological responses to EBV antigens. We hypothesized that EBV serological patterns can be useful to identify different stages of chronic lymphocytic leukemia. Methods: Information on 150 cases with chronic lymphocytic leukemia and 157 frequency-matched (by age, sex and region) population-based controls from a Spanish multicentre case-control study was obtained. EBV immunoglobulin G serostatus was evaluated through a peptide-based ELISA and further by immunoblot analysis to EBV early antigens (EA), nuclear antigen (EBNA1), VCA-p18, VCA-p40 and Zebra. Two independent individuals categorized the serological patterns of the western blot analysis. Patients with very high response and diversity in EBV-specific polypeptides, in particular with clear responses to EA-associated proteins, were categorized as having an abnormal reactive pattern (ab_EBV). Adjusted odds ratios (OR) and 95% confidence interval (CI) were estimated using logistic regression models. Results: Almost all subjects were EBV-IgG positive (>95% of cases and controls) whereas ab_EBV patterns were detected in 23% of cases (N = 34) and 11% of controls (N = 17; OR: 2.44, 95% CI, 1.29 to 4.62; P = 0.006), particularly in intermediate/high risk patients. Although based on small numbers, the association was modified by smoking with a gradual reduction of ab_EBV-related OR for all Rai stages from never smokers to current smokers. Conclusions: Highly distinct EBV antibody diversity patterns revealed by immunoblot analysis were detected in cases compared to controls, detectable at very early stages of the disease and particularly among non smokers. This study provides further evidence of an abnormal immunological response against EBV in patients with chronic lymphocytic leukemia.BioMed Central2018201820152018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/125407Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/1750-9378-10-5Infectious Agents and Cancer, 2015, vol. 10, num. 5https://doi.org/10.1186/1750-9378-10-5cc-by (c) Casabonne, Delphine et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1254072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
title Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
spellingShingle Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
Casabonne, Delphine
Leucèmia limfocítica crònica
Virus
Chronic lymphocytic leukemia
Viruses
title_short Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
title_full Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
title_fullStr Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
title_full_unstemmed Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
title_sort Aberrant Epstein-Barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study
dc.creator.none.fl_str_mv Casabonne, Delphine
Benavente, Yolanda
Robles, Claudia
Costas, Laura
Alonso Sanz, Esther
González Barca, Eva
Tardón, Adonina
Dierssen Sotos, Trinidad
Gimeno Vázquez, Eva
Aymerich Gregorio, Marta
Campo Güerri, Elias
Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pollán, Marina
Kogevinas, Manolis
Juwana, Hedy
Middeldorp, Jaap M.
Sanjosé Llongueras, Silvia de
author Casabonne, Delphine
author_facet Casabonne, Delphine
Benavente, Yolanda
Robles, Claudia
Costas, Laura
Alonso Sanz, Esther
González Barca, Eva
Tardón, Adonina
Dierssen Sotos, Trinidad
Gimeno Vázquez, Eva
Aymerich Gregorio, Marta
Campo Güerri, Elias
Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pollán, Marina
Kogevinas, Manolis
Juwana, Hedy
Middeldorp, Jaap M.
Sanjosé Llongueras, Silvia de
author_role author
author2 Benavente, Yolanda
Robles, Claudia
Costas, Laura
Alonso Sanz, Esther
González Barca, Eva
Tardón, Adonina
Dierssen Sotos, Trinidad
Gimeno Vázquez, Eva
Aymerich Gregorio, Marta
Campo Güerri, Elias
Castaño-Vinyals, Gemma
Aragonès Sanz, Núria
Pollán, Marina
Kogevinas, Manolis
Juwana, Hedy
Middeldorp, Jaap M.
Sanjosé Llongueras, Silvia de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leucèmia limfocítica crònica
Virus
Chronic lymphocytic leukemia
Viruses
topic Leucèmia limfocítica crònica
Virus
Chronic lymphocytic leukemia
Viruses
description Background: Epstein-Barr virus (EBV)-related malignancies harbour distinct serological responses to EBV antigens. We hypothesized that EBV serological patterns can be useful to identify different stages of chronic lymphocytic leukemia. Methods: Information on 150 cases with chronic lymphocytic leukemia and 157 frequency-matched (by age, sex and region) population-based controls from a Spanish multicentre case-control study was obtained. EBV immunoglobulin G serostatus was evaluated through a peptide-based ELISA and further by immunoblot analysis to EBV early antigens (EA), nuclear antigen (EBNA1), VCA-p18, VCA-p40 and Zebra. Two independent individuals categorized the serological patterns of the western blot analysis. Patients with very high response and diversity in EBV-specific polypeptides, in particular with clear responses to EA-associated proteins, were categorized as having an abnormal reactive pattern (ab_EBV). Adjusted odds ratios (OR) and 95% confidence interval (CI) were estimated using logistic regression models. Results: Almost all subjects were EBV-IgG positive (>95% of cases and controls) whereas ab_EBV patterns were detected in 23% of cases (N = 34) and 11% of controls (N = 17; OR: 2.44, 95% CI, 1.29 to 4.62; P = 0.006), particularly in intermediate/high risk patients. Although based on small numbers, the association was modified by smoking with a gradual reduction of ab_EBV-related OR for all Rai stages from never smokers to current smokers. Conclusions: Highly distinct EBV antibody diversity patterns revealed by immunoblot analysis were detected in cases compared to controls, detectable at very early stages of the disease and particularly among non smokers. This study provides further evidence of an abnormal immunological response against EBV in patients with chronic lymphocytic leukemia.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125407
url https://hdl.handle.net/2445/125407
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1750-9378-10-5
Infectious Agents and Cancer, 2015, vol. 10, num. 5
https://doi.org/10.1186/1750-9378-10-5
dc.rights.none.fl_str_mv cc-by (c) Casabonne, Delphine et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Casabonne, Delphine et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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