Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency

In different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks lymphatic circulation, the drainage and cleaning function is performed by the...

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Autores: Riba Baqués, Marta, Valle i Macià, Jaume del, Molina Porcel, Laura, Pelegrí i Gabaldà, Carme, Vilaplana i Hortensi, Jordi
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/192640
Acesso em linha:https://hdl.handle.net/2445/192640
Access Level:acceso abierto
Palavra-chave:Envelliment cerebral
Malalties neurodegeneratives
Immunitat
Aging brain
Neurodegenerative Diseases
Immunity
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spelling Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiencyRiba Baqués, MartaValle i Macià, Jaume delMolina Porcel, LauraPelegrí i Gabaldà, CarmeVilaplana i Hortensi, JordiEnvelliment cerebralMalalties neurodegenerativesImmunitatAging brainNeurodegenerative DiseasesImmunityIn different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks lymphatic circulation, the drainage and cleaning function is performed by the glymphatic system, called so for its dependence on glial cells and its similar function to that of the lymphatic system. In the present article, we define glymphatic insufficiency as the inability of the glymphatic system to properly perform the brain cleaning function. Furthermore, we propose that corpora amylacea or wasteosomes, which are protective structures that act as waste containers and accumulate waste products, are, in fact, a manifestation of chronic glymphatic insufficiency. Assuming this premise, we provide an explanation that coherently links the formation, distribution, structure, and function of these bodies in the human brain. Moreover, we open up new perspectives in the study of the glymphatic system since wasteosomes can provide information about which variables have the greatest impact on the glymphatic system and which diseases occur with chronic glymphatic insufficiency. For example, based on the presence of wasteosomes, it seems that aging, sleep disorders, and cerebrovascular pathologies have the highest impact on the glymphatic system, whereas neurodegenerative diseases have a more limited impact. Furthermore, as glymphatic insufficiency is a risk factor for neurodegenerative diseases, information provided by wasteosomes could help to define the strategies and actions that can prevent glymphatic disruptions, thus limiting the risk of developing neurodegenerative diseases.National Academy of Sciences2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/192640Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://www.pnas.org/doi/10.1073/pnas.2211326119; https://www.pnas.org/doi/10.1073/pnas.2211326119Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2022, vol. 119, num. 48, p. e2211326119(c) Riba Baques, Marta et al., 2022info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1926402026-05-27T06:46:51Z
dc.title.none.fl_str_mv Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
title Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
spellingShingle Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
Riba Baqués, Marta
Envelliment cerebral
Malalties neurodegeneratives
Immunitat
Aging brain
Neurodegenerative Diseases
Immunity
title_short Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
title_full Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
title_fullStr Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
title_full_unstemmed Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
title_sort Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency
dc.creator.none.fl_str_mv Riba Baqués, Marta
Valle i Macià, Jaume del
Molina Porcel, Laura
Pelegrí i Gabaldà, Carme
Vilaplana i Hortensi, Jordi
author Riba Baqués, Marta
author_facet Riba Baqués, Marta
Valle i Macià, Jaume del
Molina Porcel, Laura
Pelegrí i Gabaldà, Carme
Vilaplana i Hortensi, Jordi
author_role author
author2 Valle i Macià, Jaume del
Molina Porcel, Laura
Pelegrí i Gabaldà, Carme
Vilaplana i Hortensi, Jordi
author2_role author
author
author
author
dc.subject.none.fl_str_mv Envelliment cerebral
Malalties neurodegeneratives
Immunitat
Aging brain
Neurodegenerative Diseases
Immunity
topic Envelliment cerebral
Malalties neurodegeneratives
Immunitat
Aging brain
Neurodegenerative Diseases
Immunity
description In different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks lymphatic circulation, the drainage and cleaning function is performed by the glymphatic system, called so for its dependence on glial cells and its similar function to that of the lymphatic system. In the present article, we define glymphatic insufficiency as the inability of the glymphatic system to properly perform the brain cleaning function. Furthermore, we propose that corpora amylacea or wasteosomes, which are protective structures that act as waste containers and accumulate waste products, are, in fact, a manifestation of chronic glymphatic insufficiency. Assuming this premise, we provide an explanation that coherently links the formation, distribution, structure, and function of these bodies in the human brain. Moreover, we open up new perspectives in the study of the glymphatic system since wasteosomes can provide information about which variables have the greatest impact on the glymphatic system and which diseases occur with chronic glymphatic insufficiency. For example, based on the presence of wasteosomes, it seems that aging, sleep disorders, and cerebrovascular pathologies have the highest impact on the glymphatic system, whereas neurodegenerative diseases have a more limited impact. Furthermore, as glymphatic insufficiency is a risk factor for neurodegenerative diseases, information provided by wasteosomes could help to define the strategies and actions that can prevent glymphatic disruptions, thus limiting the risk of developing neurodegenerative diseases.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/192640
url https://hdl.handle.net/2445/192640
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://www.pnas.org/doi/10.1073/pnas.2211326119; https://www.pnas.org/doi/10.1073/pnas.2211326119
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2022, vol. 119, num. 48, p. e2211326119
dc.rights.none.fl_str_mv (c) Riba Baques, Marta et al., 2022
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Riba Baques, Marta et al., 2022
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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