Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles

The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chem...

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Detalhes bibliográficos
Autores: Silva, Nataly, Riveros, Ana, Yutronic, Nicolás, Lang, Erika, Chornik, Boris, Guerrero, Simón, Samitier i Martí, Josep, Jara, Paul, Kogan, Marcelo J.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/157698
Acesso em linha:https://hdl.handle.net/2445/157698
Access Level:acceso abierto
Palavra-chave:Ciclodextrines
Metotrexat
Nanopartícules
Làsers
Cyclodextrins
Methotrexate
Nanoparticles
Lasers
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oai_identifier_str oai:recercat.cat:2445/157698
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network_name_str España
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spelling Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticlesSilva, NatalyRiveros, AnaYutronic, NicolásLang, ErikaChornik, BorisGuerrero, SimónSamitier i Martí, JosepJara, PaulKogan, Marcelo J.CiclodextrinesMetotrexatNanopartículesLàsersCyclodextrinsMethotrexateNanoparticlesLasersThe inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for β-CD/MTX and AuNPs + β-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + β-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.MDPI2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/157698Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nano8120985Nanomaterials, 2018, vol. 8, num. 12, p. 985https://doi.org/10.3390/nano8120985cc-by (c) Silva, Nataly et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1576982026-05-29T05:05:01Z
dc.title.none.fl_str_mv Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
title Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
spellingShingle Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
Silva, Nataly
Ciclodextrines
Metotrexat
Nanopartícules
Làsers
Cyclodextrins
Methotrexate
Nanoparticles
Lasers
title_short Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
title_full Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
title_fullStr Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
title_full_unstemmed Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
title_sort Photothermally controlled methotrexate release system using β-cyclodextrin and gold nanoparticles
dc.creator.none.fl_str_mv Silva, Nataly
Riveros, Ana
Yutronic, Nicolás
Lang, Erika
Chornik, Boris
Guerrero, Simón
Samitier i Martí, Josep
Jara, Paul
Kogan, Marcelo J.
author Silva, Nataly
author_facet Silva, Nataly
Riveros, Ana
Yutronic, Nicolás
Lang, Erika
Chornik, Boris
Guerrero, Simón
Samitier i Martí, Josep
Jara, Paul
Kogan, Marcelo J.
author_role author
author2 Riveros, Ana
Yutronic, Nicolás
Lang, Erika
Chornik, Boris
Guerrero, Simón
Samitier i Martí, Josep
Jara, Paul
Kogan, Marcelo J.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciclodextrines
Metotrexat
Nanopartícules
Làsers
Cyclodextrins
Methotrexate
Nanoparticles
Lasers
topic Ciclodextrines
Metotrexat
Nanopartícules
Làsers
Cyclodextrins
Methotrexate
Nanoparticles
Lasers
description The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for β-CD/MTX and AuNPs + β-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + β-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/157698
url https://hdl.handle.net/2445/157698
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nano8120985
Nanomaterials, 2018, vol. 8, num. 12, p. 985
https://doi.org/10.3390/nano8120985
dc.rights.none.fl_str_mv cc-by (c) Silva, Nataly et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Silva, Nataly et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409709002326016
score 15.811543

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