Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay....

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Autores: Palacín, Arantxa, Gómez Casado, Cristina, Rivas, Luis A., Aguirre, Jacobo, Tordesillas, Leticia, Bartra Tomàs, Joan, Blanco, Carlos, Carrillo, Teresa, Cuesta Herranz, Javier, Frutos, Consolación de, García Álvarez-Eire, Genoveva, Fernández, Francisco J., Gamboa, Pedro, Muñoz-Cano, Rosa, Sánchez-Monge, Rosa, Sirvent, Sofía, Torres, María J., Varela Losada, Susana, Rodríguez, Rosalía, Parro, Victor, Blanca, Miguel, Salcedo, Gabriel, Díaz Perales, Araceli
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124688
Acesso em linha:https://hdl.handle.net/2445/124688
Access Level:acceso abierto
Palavra-chave:Al·lèrgens
Proteïnes vegetals
Immunologia
Allergens
Plant proteins
Immunology
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repository_id_str
spelling Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.Palacín, ArantxaGómez Casado, CristinaRivas, Luis A.Aguirre, JacoboTordesillas, LeticiaBartra Tomàs, JoanBlanco, CarlosCarrillo, TeresaCuesta Herranz, JavierFrutos, Consolación deGarcía Álvarez-Eire, GenovevaFernández, Francisco J.Gamboa, PedroMuñoz-Cano, RosaSánchez-Monge, RosaSirvent, SofíaTorres, María J.Varela Losada, SusanaRodríguez, RosalíaParro, VictorBlanca, MiguelSalcedo, GabrielDíaz Perales, AraceliAl·lèrgensProteïnes vegetalsImmunologiaAllergensPlant proteinsImmunologyThe study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.Public Library of Science (PLoS)2018201820122018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/124688Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0050799PLoS One, 2012, vol. 7, num. 12, p. e50799https://doi.org/10.1371/journal.pone.0050799cc-by (c) Palacín, Arantxa et al., 2012http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1246882026-05-29T05:05:01Z
dc.title.none.fl_str_mv Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
title Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
spellingShingle Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Palacín, Arantxa
Al·lèrgens
Proteïnes vegetals
Immunologia
Allergens
Plant proteins
Immunology
title_short Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
title_full Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
title_fullStr Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
title_full_unstemmed Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
title_sort Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
dc.creator.none.fl_str_mv Palacín, Arantxa
Gómez Casado, Cristina
Rivas, Luis A.
Aguirre, Jacobo
Tordesillas, Leticia
Bartra Tomàs, Joan
Blanco, Carlos
Carrillo, Teresa
Cuesta Herranz, Javier
Frutos, Consolación de
García Álvarez-Eire, Genoveva
Fernández, Francisco J.
Gamboa, Pedro
Muñoz-Cano, Rosa
Sánchez-Monge, Rosa
Sirvent, Sofía
Torres, María J.
Varela Losada, Susana
Rodríguez, Rosalía
Parro, Victor
Blanca, Miguel
Salcedo, Gabriel
Díaz Perales, Araceli
author Palacín, Arantxa
author_facet Palacín, Arantxa
Gómez Casado, Cristina
Rivas, Luis A.
Aguirre, Jacobo
Tordesillas, Leticia
Bartra Tomàs, Joan
Blanco, Carlos
Carrillo, Teresa
Cuesta Herranz, Javier
Frutos, Consolación de
García Álvarez-Eire, Genoveva
Fernández, Francisco J.
Gamboa, Pedro
Muñoz-Cano, Rosa
Sánchez-Monge, Rosa
Sirvent, Sofía
Torres, María J.
Varela Losada, Susana
Rodríguez, Rosalía
Parro, Victor
Blanca, Miguel
Salcedo, Gabriel
Díaz Perales, Araceli
author_role author
author2 Gómez Casado, Cristina
Rivas, Luis A.
Aguirre, Jacobo
Tordesillas, Leticia
Bartra Tomàs, Joan
Blanco, Carlos
Carrillo, Teresa
Cuesta Herranz, Javier
Frutos, Consolación de
García Álvarez-Eire, Genoveva
Fernández, Francisco J.
Gamboa, Pedro
Muñoz-Cano, Rosa
Sánchez-Monge, Rosa
Sirvent, Sofía
Torres, María J.
Varela Losada, Susana
Rodríguez, Rosalía
Parro, Victor
Blanca, Miguel
Salcedo, Gabriel
Díaz Perales, Araceli
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Al·lèrgens
Proteïnes vegetals
Immunologia
Allergens
Plant proteins
Immunology
topic Al·lèrgens
Proteïnes vegetals
Immunologia
Allergens
Plant proteins
Immunology
description The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
publishDate 2012
dc.date.none.fl_str_mv 2012
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124688
url https://hdl.handle.net/2445/124688
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0050799
PLoS One, 2012, vol. 7, num. 12, p. e50799
https://doi.org/10.1371/journal.pone.0050799
dc.rights.none.fl_str_mv cc-by (c) Palacín, Arantxa et al., 2012
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Palacín, Arantxa et al., 2012
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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