The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-infla...

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Autores: Tyrovolas S, Panagiotakos DB, Georgousopoulou EN, Chrysohoou C, Skoumas J, Pan W, Tousoulis D, Pitsavos C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p16395
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16395
Access Level:acceso abierto
Palabra clave:ATTICA study
Greece
anti-inflammatory diet
hepatic health
liver
nonalcoholic fatty liver disease
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spelling The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.Tyrovolas SPanagiotakos DBGeorgousopoulou ENChrysohoou CSkoumas JPan WTousoulis DPitsavos CATTICA studyGreeceanti-inflammatory diethepatic healthlivernonalcoholic fatty liver diseaseBACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected by the Dietary Anti-Inflammation Index (D-AII), and NAFLD among cardiovascular disease (CVD)-free adults. METHODS: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek population (Whites; age ?18 years; 1514 men and 1528 women). D-AII was calculated using a standard procedure. The baseline study captured various sociodemographic, lifestyle and clinical characteristics as well as hepatic markers. These were used to calculate four NAFLD assessment indices: triglyceride-glucose (TyG) index, fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD Fatty Liver Score (NAFLD-FLS). Specific cutoffs were applied to capture NAFLD. RESULTS: D-AII showed a significant inverse association with NAFLD, applying the four indices with NAFLD cutoffs [odds ratio (OR) with 95% confidence interval (CI); TyG (0.95, 0.93-0.98); HSI (0.89, 0.86-0.92); FLI (0.88, 0.85-0.91); NAFLD-FLS (0.89, 0.86-0.92)], after adjusting for various confounders. Participants in the highest D-AII tertile had lower odds of having NAFLD, compared with those in the lowest D-AII tertile [(OR, 95% CI); TyG (0.33, 0.24-0.47); HSI (0.13, 0.08-0.23); FLI (0.05, 0.02-0.11); NAFLD-FLS (0.13, 0.07-0.23)]. Anti-inflammatory nutrition was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. CONCLUSIONS: Anti-inflammatory diet is an important predictor of NAFLD among adults without pre-existing CVD. Adherence to a high anti-inflammatory diet seems to contribute to NAFLD prevention.SAGE PUBLICATIONS LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16395Therapeutic Advances in GastroenterologyISSN: 17562848ISSNl: 1756283Xreponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p163952026-05-27T12:37:41Z
dc.title.none.fl_str_mv The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
title The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
spellingShingle The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
Tyrovolas S
ATTICA study
Greece
anti-inflammatory diet
hepatic health
liver
nonalcoholic fatty liver disease
title_short The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
title_full The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
title_fullStr The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
title_full_unstemmed The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
title_sort The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.
dc.creator.none.fl_str_mv Tyrovolas S
Panagiotakos DB
Georgousopoulou EN
Chrysohoou C
Skoumas J
Pan W
Tousoulis D
Pitsavos C
author Tyrovolas S
author_facet Tyrovolas S
Panagiotakos DB
Georgousopoulou EN
Chrysohoou C
Skoumas J
Pan W
Tousoulis D
Pitsavos C
author_role author
author2 Panagiotakos DB
Georgousopoulou EN
Chrysohoou C
Skoumas J
Pan W
Tousoulis D
Pitsavos C
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ATTICA study
Greece
anti-inflammatory diet
hepatic health
liver
nonalcoholic fatty liver disease
topic ATTICA study
Greece
anti-inflammatory diet
hepatic health
liver
nonalcoholic fatty liver disease
description BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected by the Dietary Anti-Inflammation Index (D-AII), and NAFLD among cardiovascular disease (CVD)-free adults. METHODS: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek population (Whites; age ?18 years; 1514 men and 1528 women). D-AII was calculated using a standard procedure. The baseline study captured various sociodemographic, lifestyle and clinical characteristics as well as hepatic markers. These were used to calculate four NAFLD assessment indices: triglyceride-glucose (TyG) index, fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD Fatty Liver Score (NAFLD-FLS). Specific cutoffs were applied to capture NAFLD. RESULTS: D-AII showed a significant inverse association with NAFLD, applying the four indices with NAFLD cutoffs [odds ratio (OR) with 95% confidence interval (CI); TyG (0.95, 0.93-0.98); HSI (0.89, 0.86-0.92); FLI (0.88, 0.85-0.91); NAFLD-FLS (0.89, 0.86-0.92)], after adjusting for various confounders. Participants in the highest D-AII tertile had lower odds of having NAFLD, compared with those in the lowest D-AII tertile [(OR, 95% CI); TyG (0.33, 0.24-0.47); HSI (0.13, 0.08-0.23); FLI (0.05, 0.02-0.11); NAFLD-FLS (0.13, 0.07-0.23)]. Anti-inflammatory nutrition was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. CONCLUSIONS: Anti-inflammatory diet is an important predictor of NAFLD among adults without pre-existing CVD. Adherence to a high anti-inflammatory diet seems to contribute to NAFLD prevention.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16395
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16395
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
dc.source.none.fl_str_mv Therapeutic Advances in Gastroenterology
ISSN: 17562848
ISSNl: 1756283X
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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