Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
Background: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders.Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders.Design: This was a retrospective and multicentre study.Methods: We incl...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
| Repositorio: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| OAI Identifier: | oai:isabial.fundanetsuite.com:p10135 |
| Acceso en línea: | https://isabial.portalinvestigacion.com/publicaciones10135 https://journals.sagepub.com/doi/10.1177/17562848241234476 |
| Access Level: | acceso abierto |
| Palabra clave: | azathioprine immunosuppressants pouchitis thiopurines |
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Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCUMesonero, FZabana, YFernández-Clotet, ALeo-Carnerero, ECaballol, BNúñez-Ortiz, AGarcía, MJBertoletti, FMínguez, ASuris, GCasis, BFerreiro-Iglesias, RCalafat, MJiménez, IMiranda-Bautista, JLamuela, LJFajardo, ITorrealba, LNájera, RSaíz-Chumillas, RMGonzález, IVicuña, MGarcía-Morales, NGutiérrez, ALópez-García, ABenítez, JMde Célix, CRTejido, CBrunet, EHernández-Camba, ASuárez, CRodríguez-Lago, IPiqueras, MCastaño, ARamos, LSobrino, ARodríguez-Grau, MCElosua, AMontoro, MBaltar, RHuguet, JMHermida, BCaballero-Mateos, ASánchez-Guillén, LBouhmidi, APajares, RBaston-Rey, ILópez-Sanromán, AAlbillos, ABarreiro-de Acosta, MazathioprineimmunosuppressantspouchitisthiopurinesBackground: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders.Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders.Design: This was a retrospective and multicentre study.Methods: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response). Endoscopic response was evaluated using the Pouchitis Disease Activity Index (PDAI).Results: In all, 63 patients were included [54% males; median age, 49 (28-77) years]. The therapy was used to treat pouchitis (n = 37) or Crohn's disease of the pouch (n = 26). The rate of clinical response, remission and non-response at 12 months were 52%, 30% and 18%, respectively. After a median follow-up of 23 months (interquartile range 11-55), 19 patients (30%) were in clinical remission, and 45 (66%) stopped therapy. Endoscopic changes were evaluated in 19 cases. PDAI score decreased from 3 (range 2-4) to 1 (range 0-3). In all, 21 patients (33%) presented adverse events and 16 (25%) needed to stop therapy.Conclusion: Azathioprine may be effective in the long term for the treatment of inflammatory pouch disorders and could be included as a therapeutic option.SAGE PUBLICATIONS LTD2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones10135https://journals.sagepub.com/doi/10.1177/17562848241234476Therapeutic Advances in GastroenterologyISSN: 1756283XISSNe: 17562848reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p101352026-06-12T10:20:37Z |
| dc.title.none.fl_str_mv |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| title |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| spellingShingle |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU Mesonero, F azathioprine immunosuppressants pouchitis thiopurines |
| title_short |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| title_full |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| title_fullStr |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| title_full_unstemmed |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| title_sort |
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
| dc.creator.none.fl_str_mv |
Mesonero, F Zabana, Y Fernández-Clotet, A Leo-Carnerero, E Caballol, B Núñez-Ortiz, A García, MJ Bertoletti, F Mínguez, A Suris, G Casis, B Ferreiro-Iglesias, R Calafat, M Jiménez, I Miranda-Bautista, J Lamuela, LJ Fajardo, I Torrealba, L Nájera, R Saíz-Chumillas, RM González, I Vicuña, M García-Morales, N Gutiérrez, A López-García, A Benítez, JM de Célix, CR Tejido, C Brunet, E Hernández-Camba, A Suárez, C Rodríguez-Lago, I Piqueras, M Castaño, A Ramos, L Sobrino, A Rodríguez-Grau, MC Elosua, A Montoro, M Baltar, R Huguet, JM Hermida, B Caballero-Mateos, A Sánchez-Guillén, L Bouhmidi, A Pajares, R Baston-Rey, I López-Sanromán, A Albillos, A Barreiro-de Acosta, M |
| author |
Mesonero, F |
| author_facet |
Mesonero, F Zabana, Y Fernández-Clotet, A Leo-Carnerero, E Caballol, B Núñez-Ortiz, A García, MJ Bertoletti, F Mínguez, A Suris, G Casis, B Ferreiro-Iglesias, R Calafat, M Jiménez, I Miranda-Bautista, J Lamuela, LJ Fajardo, I Torrealba, L Nájera, R Saíz-Chumillas, RM González, I Vicuña, M García-Morales, N Gutiérrez, A López-García, A Benítez, JM de Célix, CR Tejido, C Brunet, E Hernández-Camba, A Suárez, C Rodríguez-Lago, I Piqueras, M Castaño, A Ramos, L Sobrino, A Rodríguez-Grau, MC Elosua, A Montoro, M Baltar, R Huguet, JM Hermida, B Caballero-Mateos, A Sánchez-Guillén, L Bouhmidi, A Pajares, R Baston-Rey, I López-Sanromán, A Albillos, A Barreiro-de Acosta, M |
| author_role |
author |
| author2 |
Zabana, Y Fernández-Clotet, A Leo-Carnerero, E Caballol, B Núñez-Ortiz, A García, MJ Bertoletti, F Mínguez, A Suris, G Casis, B Ferreiro-Iglesias, R Calafat, M Jiménez, I Miranda-Bautista, J Lamuela, LJ Fajardo, I Torrealba, L Nájera, R Saíz-Chumillas, RM González, I Vicuña, M García-Morales, N Gutiérrez, A López-García, A Benítez, JM de Célix, CR Tejido, C Brunet, E Hernández-Camba, A Suárez, C Rodríguez-Lago, I Piqueras, M Castaño, A Ramos, L Sobrino, A Rodríguez-Grau, MC Elosua, A Montoro, M Baltar, R Huguet, JM Hermida, B Caballero-Mateos, A Sánchez-Guillén, L Bouhmidi, A Pajares, R Baston-Rey, I López-Sanromán, A Albillos, A Barreiro-de Acosta, M |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
azathioprine immunosuppressants pouchitis thiopurines |
| topic |
azathioprine immunosuppressants pouchitis thiopurines |
| description |
Background: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders.Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders.Design: This was a retrospective and multicentre study.Methods: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response). Endoscopic response was evaluated using the Pouchitis Disease Activity Index (PDAI).Results: In all, 63 patients were included [54% males; median age, 49 (28-77) years]. The therapy was used to treat pouchitis (n = 37) or Crohn's disease of the pouch (n = 26). The rate of clinical response, remission and non-response at 12 months were 52%, 30% and 18%, respectively. After a median follow-up of 23 months (interquartile range 11-55), 19 patients (30%) were in clinical remission, and 45 (66%) stopped therapy. Endoscopic changes were evaluated in 19 cases. PDAI score decreased from 3 (range 2-4) to 1 (range 0-3). In all, 21 patients (33%) presented adverse events and 16 (25%) needed to stop therapy.Conclusion: Azathioprine may be effective in the long term for the treatment of inflammatory pouch disorders and could be included as a therapeutic option. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://isabial.portalinvestigacion.com/publicaciones10135 https://journals.sagepub.com/doi/10.1177/17562848241234476 |
| url |
https://isabial.portalinvestigacion.com/publicaciones10135 https://journals.sagepub.com/doi/10.1177/17562848241234476 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
SAGE PUBLICATIONS LTD |
| publisher.none.fl_str_mv |
SAGE PUBLICATIONS LTD |
| dc.source.none.fl_str_mv |
Therapeutic Advances in Gastroenterology ISSN: 1756283X ISSNe: 17562848 reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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1869409670720913408 |
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15.81155 |