Hypoxia in the Initiation and Progression of Neuroblastoma Tumours

Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tis...

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Detalhes bibliográficos
Autores: Huertas Castaño, Carlos, Gómez Muñoz, María Ángeles, Pardal Redondo, Ricardo, Vega Moreno, Francisco Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/93246
Acesso em linha:https://hdl.handle.net/11441/93246
https://doi.org/10.3390/ijms21010039
Access Level:acceso abierto
Palavra-chave:cancer stem cells
hypoxia
neural crest cells
neuroblastoma
paediatric oncology
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spelling Hypoxia in the Initiation and Progression of Neuroblastoma TumoursHuertas Castaño, CarlosGómez Muñoz, María ÁngelesPardal Redondo, RicardoVega Moreno, Francisco Manuelcancer stem cellshypoxianeural crest cellsneuroblastomapaediatric oncologyNeuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a cellular stimulus with important consequences for tumour initiation, evolution and progression. In neuroblastoma, several evidences point towards a role of hypoxia in tumour initiation during development, tumour cell differentiation, survival and metastatic spreading. However, the heterogeneous nature of the disease, its developmental origin and the lack of suitable experimental models have complicated a clear understanding of the effect of hypoxia in neuroblastoma tumour progression and the molecular mechanisms implicated. In this review, we have compiled available evidences to try to shed light onto this important field. In particular, we explore the effect of hypoxia in neuroblastoma cell transformation and differentiation. We also discuss the experimental models available and the emerging alternatives to study this problem, and we present hypoxia-related therapeutic avenues being explored in the field.Spanish Ministry of Science and Innovation SAF program (grant number SAF2016-80412-P)MDPIBiología CelularFisiología Médica y Biofísica2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/93246https://doi.org/10.3390/ijms21010039reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Molecular Sciences, 21 (1), 39.SAF2016-80412-Phttps://doi.org/10.3390/ijms21010039info:eu-repo/semantics/openAccessoai:idus.us.es:11441/932462026-06-17T12:51:07Z
dc.title.none.fl_str_mv Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
title Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
spellingShingle Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
Huertas Castaño, Carlos
cancer stem cells
hypoxia
neural crest cells
neuroblastoma
paediatric oncology
title_short Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
title_full Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
title_fullStr Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
title_full_unstemmed Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
title_sort Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
dc.creator.none.fl_str_mv Huertas Castaño, Carlos
Gómez Muñoz, María Ángeles
Pardal Redondo, Ricardo
Vega Moreno, Francisco Manuel
author Huertas Castaño, Carlos
author_facet Huertas Castaño, Carlos
Gómez Muñoz, María Ángeles
Pardal Redondo, Ricardo
Vega Moreno, Francisco Manuel
author_role author
author2 Gómez Muñoz, María Ángeles
Pardal Redondo, Ricardo
Vega Moreno, Francisco Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Biología Celular
Fisiología Médica y Biofísica
dc.subject.none.fl_str_mv cancer stem cells
hypoxia
neural crest cells
neuroblastoma
paediatric oncology
topic cancer stem cells
hypoxia
neural crest cells
neuroblastoma
paediatric oncology
description Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a cellular stimulus with important consequences for tumour initiation, evolution and progression. In neuroblastoma, several evidences point towards a role of hypoxia in tumour initiation during development, tumour cell differentiation, survival and metastatic spreading. However, the heterogeneous nature of the disease, its developmental origin and the lack of suitable experimental models have complicated a clear understanding of the effect of hypoxia in neuroblastoma tumour progression and the molecular mechanisms implicated. In this review, we have compiled available evidences to try to shed light onto this important field. In particular, we explore the effect of hypoxia in neuroblastoma cell transformation and differentiation. We also discuss the experimental models available and the emerging alternatives to study this problem, and we present hypoxia-related therapeutic avenues being explored in the field.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/93246
https://doi.org/10.3390/ijms21010039
url https://hdl.handle.net/11441/93246
https://doi.org/10.3390/ijms21010039
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences, 21 (1), 39.
SAF2016-80412-P
https://doi.org/10.3390/ijms21010039
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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