Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence

A few studies linked air pollution to differences in functional connectivity of resting-state brain networks in children, but how air pollution exposure affects the development of brain networks remains poorly understood. Therefore, we studied the association of air pollution exposure from birth to...

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Detalles Bibliográficos
Autores: S.W. Kusters, Michelle, Granés, Laura, Petricola, Sami, Tiemeier, Henning, Muetzel, Ryan, Guxens, Mònica
Tipo de recurso: conjunto de datos
Fecha de publicación:2025
País:España
Institución:Consorci de Serveis Universitaris de Catalunya (CSUC)
Repositorio:CORA.Repositori de Dades de Recerca
OAI Identifier:oai:dnet:cora.rdr____::b2fe2a600926f5f9832372a63f7e2fc8
Acceso en línea:https://doi.org/10.34810/DATA2675
Access Level:acceso abierto
Palabra clave:Medicine, Health and Life Sciences
Environmental pollution
Air pollutants
Brain development
Functional connectivity
Resting-state functional MRI
Cohort studies
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spelling Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescenceS.W. Kusters, MichelleGranés, LauraPetricola, SamiTiemeier, HenningMuetzel, RyanGuxens, MònicaMedicine, Health and Life SciencesEnvironmental pollutionAir pollutantsBrain developmentFunctional connectivityResting-state functional MRICohort studiesA few studies linked air pollution to differences in functional connectivity of resting-state brain networks in children, but how air pollution exposure affects the development of brain networks remains poorly understood. Therefore, we studied the association of air pollution exposure from birth to 3 years and one year before the first imaging assessment with the development of functional connectivity across adolescence.<br>We utilized data from 3,626 children of the Generation R Study (The Netherlands). We estimated residential exposure to PM10, PM2.5, PM2.5 absorbance, NOX, and NO2 with land-use regression models. Between- and within-network functional connectivity was calculated for 13 cortical networks, and the amygdala, hippocampus, and caudate nucleus at two assessments (8.6–12.0 and 12.6–17.1 years), resulting in 4,628 scans (2,511 for assessment 1 and 2,117 for assessment 2) from 3,626 individuals. We investigated the association between air pollution and functional connectivity with linear mixed models adjusted for life-style and socioeconomic variables, and corrected for multiple testing.<br>Higher exposure to PM2.5 from birth to 3 years was associated with persistently lower functional connectivity over time between the amygdala and the ventral attention, somatomotor hand, and auditory networks throughout adolescence (e.g. −0.027 functional connectivity [95 % CI −0.040; −0.013] amygdala – ventral attention network per 5 μg/m3 higher PM2.5). Higher exposure to PM10 one year before the first imaging assessment was associated with persistently lower functional connectivity between the salience and medial-parietal networks throughout adolescence. Air pollution was not associated with a faster or slower change in functional connectivity with age.<br>Air pollution exposure early in life was associated with persistent alterations in connectivity between the amygdala and cortical networks involved in attention, somatomotor, and auditory function. Concurrent exposure was associated with persistent connectivity alterations between networks related to higher cognitive functions (i.e. the salience and medial-parietal networks).CORA.Repositori de Dades de Recerca2025info:eu-repo/semantics/datasethttps://doi.org/10.34810/DATA2675reponame:CORA.Repositori de Dades de Recercainstname:Consorci de Serveis Universitaris de Catalunya (CSUC)Inglésinfo:eu-repo/semantics/openAccessCC BY-NC-SA 4.0oai:dnet:cora.rdr____::b2fe2a600926f5f9832372a63f7e2fc82026-06-17T12:20:17Z
dc.title.none.fl_str_mv Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
title Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
spellingShingle Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
S.W. Kusters, Michelle
Medicine, Health and Life Sciences
Environmental pollution
Air pollutants
Brain development
Functional connectivity
Resting-state functional MRI
Cohort studies
title_short Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
title_full Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
title_fullStr Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
title_full_unstemmed Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
title_sort Replication Data for: Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
dc.creator.none.fl_str_mv S.W. Kusters, Michelle
Granés, Laura
Petricola, Sami
Tiemeier, Henning
Muetzel, Ryan
Guxens, Mònica
author S.W. Kusters, Michelle
author_facet S.W. Kusters, Michelle
Granés, Laura
Petricola, Sami
Tiemeier, Henning
Muetzel, Ryan
Guxens, Mònica
author_role author
author2 Granés, Laura
Petricola, Sami
Tiemeier, Henning
Muetzel, Ryan
Guxens, Mònica
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Medicine, Health and Life Sciences
Environmental pollution
Air pollutants
Brain development
Functional connectivity
Resting-state functional MRI
Cohort studies
topic Medicine, Health and Life Sciences
Environmental pollution
Air pollutants
Brain development
Functional connectivity
Resting-state functional MRI
Cohort studies
description A few studies linked air pollution to differences in functional connectivity of resting-state brain networks in children, but how air pollution exposure affects the development of brain networks remains poorly understood. Therefore, we studied the association of air pollution exposure from birth to 3 years and one year before the first imaging assessment with the development of functional connectivity across adolescence.<br>We utilized data from 3,626 children of the Generation R Study (The Netherlands). We estimated residential exposure to PM10, PM2.5, PM2.5 absorbance, NOX, and NO2 with land-use regression models. Between- and within-network functional connectivity was calculated for 13 cortical networks, and the amygdala, hippocampus, and caudate nucleus at two assessments (8.6–12.0 and 12.6–17.1 years), resulting in 4,628 scans (2,511 for assessment 1 and 2,117 for assessment 2) from 3,626 individuals. We investigated the association between air pollution and functional connectivity with linear mixed models adjusted for life-style and socioeconomic variables, and corrected for multiple testing.<br>Higher exposure to PM2.5 from birth to 3 years was associated with persistently lower functional connectivity over time between the amygdala and the ventral attention, somatomotor hand, and auditory networks throughout adolescence (e.g. −0.027 functional connectivity [95 % CI −0.040; −0.013] amygdala – ventral attention network per 5 μg/m3 higher PM2.5). Higher exposure to PM10 one year before the first imaging assessment was associated with persistently lower functional connectivity between the salience and medial-parietal networks throughout adolescence. Air pollution was not associated with a faster or slower change in functional connectivity with age.<br>Air pollution exposure early in life was associated with persistent alterations in connectivity between the amygdala and cortical networks involved in attention, somatomotor, and auditory function. Concurrent exposure was associated with persistent connectivity alterations between networks related to higher cognitive functions (i.e. the salience and medial-parietal networks).
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv https://doi.org/10.34810/DATA2675
url https://doi.org/10.34810/DATA2675
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
CC BY-NC-SA 4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv CC BY-NC-SA 4.0
dc.publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
publisher.none.fl_str_mv CORA.Repositori de Dades de Recerca
dc.source.none.fl_str_mv reponame:CORA.Repositori de Dades de Recerca
instname:Consorci de Serveis Universitaris de Catalunya (CSUC)
instname_str Consorci de Serveis Universitaris de Catalunya (CSUC)
reponame_str CORA.Repositori de Dades de Recerca
collection CORA.Repositori de Dades de Recerca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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