Norovirus outbreaks in long-term care facilities in Catalonia from 2017 to 2018

Norovirus is the leading cause of outbreaks of acute viral gastroenteritis. We carried out this study to investigate outbreaks in long-term care facilities reported in 2017 and 2018 in Catalonia (Spain). The characteristics of the centers, exposed persons and the genogroups responsible were analyzed...

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Detalles Bibliográficos
Autores: Parrón, Ignacio|||0000-0002-4875-0236, Barrabeig, Irene|||0000-0003-4789-7620, Alsedà, Miquel|||0000-0003-4008-3616, Rius i Gibert, Maria Cristina|||0000-0001-5189-6503, Cornejo-Sánchez, Thais|||0000-0002-1350-0413, Jané i Checa, Mireia|||0000-0002-1302-6723, Pérez, Cristina, Guix, Susana|||0000-0002-1588-3198, Domínguez, Ángela|||0000-0003-0219-1907
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:264456
Acceso en línea:https://ddd.uab.cat/record/264456
https://dx.doi.org/urn:doi:10.1038/s41598-021-02348-2
Access Level:acceso abierto
Palabra clave:Adult
Aged
Aged, 80 and over
Caliciviridae Infections
Disease Outbreaks
Female
Gastroenteritis
Humans
Long-Term Care
Male
Middle Aged
Norovirus
Nursing Homes
Prospective Studies
Spain
Young Adult
Descripción
Sumario:Norovirus is the leading cause of outbreaks of acute viral gastroenteritis. We carried out this study to investigate outbreaks in long-term care facilities reported in 2017 and 2018 in Catalonia (Spain). The characteristics of the centers, exposed persons and the genogroups responsible were analyzed. Viral loads were estimated. The attack rate (AR) of the outbreaks studied, and the rate ratio (RR) and the odds ratio (OR) and their 95% confidence intervals as measures of association were calculated. The mean cycle thresholds were compared using the t-test for independent means. We included 30 outbreaks (4631 exposed people). The global AR was 25.93%. The RR of residents vs. staff was 2.28 (95% CI 2.0-2.6). The RR between AR in residents with total or severe dependence vs. residents with moderate, low or no-dependence was 1.23 (95% CI 1.05-1.45). The AR were higher in smaller centers than in larger ones (38.47% vs. 19.25% and RR 2; 95% CI 1.82-2.2). GII was responsible for 70% of outbreaks. No association was found between the genogroup and presenting symptoms (OR 0.96; 95% CI 0.41-2.26). Viral loads were higher in symptomatic than in asymptomatic patients (p = 0.001).

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