Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019

Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. N...

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Autores: Mengual-Chuliá B, Alonso-Cordero A, Cano L, Del Mar Mosquera M, de Molina P, Vendrell R, Reyes-Prieto M, Jané M, Torner N, Martínez AI, Vila J, Díez-Domingo J, Ángeles Marcos M, Xavier López-Labrador F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p9297
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/9297
Access Level:acceso abierto
Palabra clave:next-generation sequencing
whole-genome sequencing
antivirals
favipiravir
pimodivir
baloxavir
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spelling Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019Mengual-Chuliá BAlonso-Cordero ACano LDel Mar Mosquera Mde Molina PVendrell RReyes-Prieto MJané MTorner NMartínez AIVila JDíez-Domingo JÁngeles Marcos MXavier López-Labrador Fnext-generation sequencingwhole-genome sequencingantiviralsfavipiravirpimodivirbaloxavirMolecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.AMER SOC MICROBIOLOGY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/9297ANTIMICROBIAL AGENTS AND CHEMOTHERAPYISSN: 00664804ISSNe: 10986596reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p92972026-06-11T12:45:17Z
dc.title.none.fl_str_mv Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
title Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
spellingShingle Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
Mengual-Chuliá B
next-generation sequencing
whole-genome sequencing
antivirals
favipiravir
pimodivir
baloxavir
title_short Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
title_full Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
title_fullStr Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
title_full_unstemmed Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
title_sort Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019
dc.creator.none.fl_str_mv Mengual-Chuliá B
Alonso-Cordero A
Cano L
Del Mar Mosquera M
de Molina P
Vendrell R
Reyes-Prieto M
Jané M
Torner N
Martínez AI
Vila J
Díez-Domingo J
Ángeles Marcos M
Xavier López-Labrador F
author Mengual-Chuliá B
author_facet Mengual-Chuliá B
Alonso-Cordero A
Cano L
Del Mar Mosquera M
de Molina P
Vendrell R
Reyes-Prieto M
Jané M
Torner N
Martínez AI
Vila J
Díez-Domingo J
Ángeles Marcos M
Xavier López-Labrador F
author_role author
author2 Alonso-Cordero A
Cano L
Del Mar Mosquera M
de Molina P
Vendrell R
Reyes-Prieto M
Jané M
Torner N
Martínez AI
Vila J
Díez-Domingo J
Ángeles Marcos M
Xavier López-Labrador F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv next-generation sequencing
whole-genome sequencing
antivirals
favipiravir
pimodivir
baloxavir
topic next-generation sequencing
whole-genome sequencing
antivirals
favipiravir
pimodivir
baloxavir
description Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/9297
url https://fisabio.portalinvestigacion.com/publicaciones/9297
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AMER SOC MICROBIOLOGY
publisher.none.fl_str_mv AMER SOC MICROBIOLOGY
dc.source.none.fl_str_mv ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN: 00664804
ISSNe: 10986596
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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