Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review

Background Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to...

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Autores: Santos Carrasco, Daniel, Casa Rivas, Luis Gonzalo de La
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/148443
Acceso en línea:https://hdl.handle.net/11441/148443
https://doi.org/10.1186/s40359-023-01253-9
Access Level:acceso abierto
Palabra clave:Sensorimotor gating
Prepulse inhibition
Startle response
Neuropsychiatric disorders
Transdiagnostic process
Pre-attentional filtering
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spelling Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic reviewSantos Carrasco, DanielCasa Rivas, Luis Gonzalo de LaSensorimotor gatingPrepulse inhibitionStartle responseNeuropsychiatric disordersTransdiagnostic processPre-attentional filteringBackground Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced if a weak stimulus, or prepulse, is previously presented. Objective and methods The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic process for four main groups of neuropsychiatric disorders: (1) trauma-, stress-, and anxiety-related disorders (2) mood-related disorders, (3) neurocognitive disorders, and (4) other disorders such as obsessive-compulsive, tic- related, and substance use disorders. We used Web of Science, PubMed and PsycInfo databases to search for experimental case-control articles that were analyzed both qualitatively and based on their potential risk of bias. A total of 64 studies were included in this systematic review. Protocol was submitted prospectively to PROSPERO 04/30/2022 (CRD42022322031). Results and conclusion The results showed a general PPI deficit in the diagnostic groups mentioned, with associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded that the PPI deficit appears across most of the neuropsychiatric disorders examined, and it could be considered as a relevant measure in translational research for the early detection of such disorders.Ministerio de Ciencia e Innovación-AEI PID2019-107530GB-I00BioMed CentralPsicología ExperimentalMinisterio de Ciencia e Innovación (MICIN). España2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/148443https://doi.org/10.1186/s40359-023-01253-9reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBMC Psychology, 11, 226, 1-22.PID2019-107530GB-I00https://doi.org/10.1186/s40359-023-01253-9info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1484432026-06-17T12:51:07Z
dc.title.none.fl_str_mv Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
title Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
spellingShingle Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
Santos Carrasco, Daniel
Sensorimotor gating
Prepulse inhibition
Startle response
Neuropsychiatric disorders
Transdiagnostic process
Pre-attentional filtering
title_short Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
title_full Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
title_fullStr Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
title_full_unstemmed Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
title_sort Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review
dc.creator.none.fl_str_mv Santos Carrasco, Daniel
Casa Rivas, Luis Gonzalo de La
author Santos Carrasco, Daniel
author_facet Santos Carrasco, Daniel
Casa Rivas, Luis Gonzalo de La
author_role author
author2 Casa Rivas, Luis Gonzalo de La
author2_role author
dc.contributor.none.fl_str_mv Psicología Experimental
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv Sensorimotor gating
Prepulse inhibition
Startle response
Neuropsychiatric disorders
Transdiagnostic process
Pre-attentional filtering
topic Sensorimotor gating
Prepulse inhibition
Startle response
Neuropsychiatric disorders
Transdiagnostic process
Pre-attentional filtering
description Background Psychopathological research is moving from a specific approach towards transdiagnosis through the analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced if a weak stimulus, or prepulse, is previously presented. Objective and methods The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic process for four main groups of neuropsychiatric disorders: (1) trauma-, stress-, and anxiety-related disorders (2) mood-related disorders, (3) neurocognitive disorders, and (4) other disorders such as obsessive-compulsive, tic- related, and substance use disorders. We used Web of Science, PubMed and PsycInfo databases to search for experimental case-control articles that were analyzed both qualitatively and based on their potential risk of bias. A total of 64 studies were included in this systematic review. Protocol was submitted prospectively to PROSPERO 04/30/2022 (CRD42022322031). Results and conclusion The results showed a general PPI deficit in the diagnostic groups mentioned, with associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded that the PPI deficit appears across most of the neuropsychiatric disorders examined, and it could be considered as a relevant measure in translational research for the early detection of such disorders.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/148443
https://doi.org/10.1186/s40359-023-01253-9
url https://hdl.handle.net/11441/148443
https://doi.org/10.1186/s40359-023-01253-9
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BMC Psychology, 11, 226, 1-22.
PID2019-107530GB-I00
https://doi.org/10.1186/s40359-023-01253-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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