Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival

Background Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8 th edition AJCC TNM (ICON-S model). However, it is still unclear the...

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Autores: Taberna, Miren, Mena Cervigón, Marisa, Tous, Sara, Pavón Ribas, Miquel Àngel, Oliva, Marc, León, Xavier, Garcia, Jacinto, Guix, Marta, Hijano, Rafael, Bonfill, Teresa, Aguilà, Anton, Alemany i Vilches, Laia, Mesía Nin, Ricard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/123919
Acceso en línea:https://hdl.handle.net/2445/123919
Access Level:acceso abierto
Palabra clave:Papil·lomavirus
Càncer de coll
Papillomaviruses
Neck cancer
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repository_id_str
spelling Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' SurvivalTaberna, MirenMena Cervigón, MarisaTous, SaraPavón Ribas, Miquel ÀngelOliva, MarcLeón, XavierGarcia, JacintoGuix, MartaHijano, RafaelBonfill, TeresaAguilà, AntonAlemany i Vilches, LaiaMesía Nin, RicardPapil·lomavirusCàncer de collPapillomavirusesNeck cancerBackground Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8 th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. Material and methods The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7 th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16(INK4a) or HPV-mRNA), p16(INK4a) positivity alone or the combination of HPV-DNA/p16(INK4a) positivity as diagnostic tests. Results A total of 788 consecutive OPC cases diagnosed from 1991 to 2013 were considered eligible for the analysis. Of these samples, 66 (8.4%) were positive for HPV-DNA and (p16(INK4a) or HPV-mRNA), 83 (10.5%) were p16(INK4a) positive and 58 (7.4%) were double positive for HPV-DNA/p16(INK4a). ICON-S model was the staging system, which performed better in our series when using at least two biomarkers to define HPV-causality. When the same analysis was performed considering only p16(INK4a)-positivity, RPA stage with non-anatomic factors (Princess Margaret) has the best classification based on AIC criteria. Conclusion HPV-relatedness definition for classifying HPV-related OPC patient do impact on TNM classification and patients' survival. Further studies assessing HPV-relatedness definitions are warranted to better classify HPV-related OPC patients in the era of de-escalation clinical trials.Public Library Science2018201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/123919Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0194107Plos One, 2018, Vol. 13, Issue 4: e0194107https://doi.org/10.1371/journal.pone.0194107info:eu-repo/grantAgreement/EC/FP7/603019cc by (c) Taberna, Miren et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1239192026-05-29T05:05:01Z
dc.title.none.fl_str_mv Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
title Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
spellingShingle Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
Taberna, Miren
Papil·lomavirus
Càncer de coll
Papillomaviruses
Neck cancer
title_short Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
title_full Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
title_fullStr Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
title_full_unstemmed Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
title_sort Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival
dc.creator.none.fl_str_mv Taberna, Miren
Mena Cervigón, Marisa
Tous, Sara
Pavón Ribas, Miquel Àngel
Oliva, Marc
León, Xavier
Garcia, Jacinto
Guix, Marta
Hijano, Rafael
Bonfill, Teresa
Aguilà, Anton
Alemany i Vilches, Laia
Mesía Nin, Ricard
author Taberna, Miren
author_facet Taberna, Miren
Mena Cervigón, Marisa
Tous, Sara
Pavón Ribas, Miquel Àngel
Oliva, Marc
León, Xavier
Garcia, Jacinto
Guix, Marta
Hijano, Rafael
Bonfill, Teresa
Aguilà, Anton
Alemany i Vilches, Laia
Mesía Nin, Ricard
author_role author
author2 Mena Cervigón, Marisa
Tous, Sara
Pavón Ribas, Miquel Àngel
Oliva, Marc
León, Xavier
Garcia, Jacinto
Guix, Marta
Hijano, Rafael
Bonfill, Teresa
Aguilà, Anton
Alemany i Vilches, Laia
Mesía Nin, Ricard
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Càncer de coll
Papillomaviruses
Neck cancer
topic Papil·lomavirus
Càncer de coll
Papillomaviruses
Neck cancer
description Background Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8 th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. Material and methods The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7 th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16(INK4a) or HPV-mRNA), p16(INK4a) positivity alone or the combination of HPV-DNA/p16(INK4a) positivity as diagnostic tests. Results A total of 788 consecutive OPC cases diagnosed from 1991 to 2013 were considered eligible for the analysis. Of these samples, 66 (8.4%) were positive for HPV-DNA and (p16(INK4a) or HPV-mRNA), 83 (10.5%) were p16(INK4a) positive and 58 (7.4%) were double positive for HPV-DNA/p16(INK4a). ICON-S model was the staging system, which performed better in our series when using at least two biomarkers to define HPV-causality. When the same analysis was performed considering only p16(INK4a)-positivity, RPA stage with non-anatomic factors (Princess Margaret) has the best classification based on AIC criteria. Conclusion HPV-relatedness definition for classifying HPV-related OPC patient do impact on TNM classification and patients' survival. Further studies assessing HPV-relatedness definitions are warranted to better classify HPV-related OPC patients in the era of de-escalation clinical trials.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/123919
url https://hdl.handle.net/2445/123919
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0194107
Plos One, 2018, Vol. 13, Issue 4: e0194107
https://doi.org/10.1371/journal.pone.0194107
info:eu-repo/grantAgreement/EC/FP7/603019
dc.rights.none.fl_str_mv cc by (c) Taberna, Miren et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Taberna, Miren et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library Science
publisher.none.fl_str_mv Public Library Science
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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