Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
Objective:: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods:: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was acc...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/118713 |
| Acesso em linha: | https://hdl.handle.net/2445/118713 |
| Access Level: | acceso abierto |
| Palavra-chave: | Trastorn bipolar Trastorns de la cognició Neuropsicologia Manic-depressive illness Cognition disorders Neuropsychology |
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Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controlsVasconcelos-Moreno, Mirela P.Bücker, JoanaBürke, Kelen P.Czepielewski, LeticiaSantos, Barbara T.Fijtman, AdamPassos, Ives C.Kunz, MauricioBonnín Roig, Caterina del MarVieta i Pascual, Eduard, 1963-Kapczinski, FlávioRosa, Adriane RibeiroKauer-Sant'Anna, MarciaTrastorn bipolarTrastorns de la cognicióNeuropsicologiaManic-depressive illnessCognition disordersNeuropsychologyObjective:: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods:: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results:: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion:: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.Associação Brasileira de Psiquiatria2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/118713Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1590/1516-4446-2015-1868Revista Brasileira de Psiquiatria, 2016, vol. 38, num. 4, p. 275-280https://doi.org/10.1590/1516-4446-2015-1868cc-by-nc (c) Associação Brasileira de Psiquiatria, 2016http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1187132026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| spellingShingle |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls Vasconcelos-Moreno, Mirela P. Trastorn bipolar Trastorns de la cognició Neuropsicologia Manic-depressive illness Cognition disorders Neuropsychology |
| title_short |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_full |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_fullStr |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_full_unstemmed |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_sort |
Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| dc.creator.none.fl_str_mv |
Vasconcelos-Moreno, Mirela P. Bücker, Joana Bürke, Kelen P. Czepielewski, Leticia Santos, Barbara T. Fijtman, Adam Passos, Ives C. Kunz, Mauricio Bonnín Roig, Caterina del Mar Vieta i Pascual, Eduard, 1963- Kapczinski, Flávio Rosa, Adriane Ribeiro Kauer-Sant'Anna, Marcia |
| author |
Vasconcelos-Moreno, Mirela P. |
| author_facet |
Vasconcelos-Moreno, Mirela P. Bücker, Joana Bürke, Kelen P. Czepielewski, Leticia Santos, Barbara T. Fijtman, Adam Passos, Ives C. Kunz, Mauricio Bonnín Roig, Caterina del Mar Vieta i Pascual, Eduard, 1963- Kapczinski, Flávio Rosa, Adriane Ribeiro Kauer-Sant'Anna, Marcia |
| author_role |
author |
| author2 |
Bücker, Joana Bürke, Kelen P. Czepielewski, Leticia Santos, Barbara T. Fijtman, Adam Passos, Ives C. Kunz, Mauricio Bonnín Roig, Caterina del Mar Vieta i Pascual, Eduard, 1963- Kapczinski, Flávio Rosa, Adriane Ribeiro Kauer-Sant'Anna, Marcia |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Trastorn bipolar Trastorns de la cognició Neuropsicologia Manic-depressive illness Cognition disorders Neuropsychology |
| topic |
Trastorn bipolar Trastorns de la cognició Neuropsicologia Manic-depressive illness Cognition disorders Neuropsychology |
| description |
Objective:: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods:: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results:: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion:: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2017 2017 2017 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/118713 |
| url |
https://hdl.handle.net/2445/118713 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1590/1516-4446-2015-1868 Revista Brasileira de Psiquiatria, 2016, vol. 38, num. 4, p. 275-280 https://doi.org/10.1590/1516-4446-2015-1868 |
| dc.rights.none.fl_str_mv |
cc-by-nc (c) Associação Brasileira de Psiquiatria, 2016 http://creativecommons.org/licenses/by-nc/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by-nc (c) Associação Brasileira de Psiquiatria, 2016 http://creativecommons.org/licenses/by-nc/3.0/es |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
6 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
| publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869409580766724097 |
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15.811543 |