2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble var...

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Detalles Bibliográficos
Autores: Suárez-Calvet, Marc|||0000-0002-2993-569X, Kleinberger, Gernot|||0000-0002-5811-8226, Araque Caballero, Miguel Ángel, Brendel, Matthias|||0000-0002-9247-2843, Rominger, Axel, Alcolea, Daniel|||0000-0002-3819-3245, Fortea, Juan|||0000-0002-1340-638X, Lleó, Alberto|||0000-0002-2568-5478, Blesa, Rafael|||0000-0003-4026-2884, Gispert, Juan Domingo|||0000-0002-6155-0642, Sanchez-Valle, Raquel|||0000-0001-7750-896X, Antonell, Anna|||0000-0002-3286-8459, Rami Gonzalez, Lorena|||0000-0002-7411-1921, Molinuevo, José Luis|||0000-0003-0485-6001, Brosseron, Frederic, Traschütz, Andreas, Heneka, Michael|||0000-0003-4996-1630, Struyfs, Hanne, Engelborghs, Sebastiaan|||0000-0003-0304-9785, Sleegers, Kristel|||0000-0002-0283-2332, Van Broeckhoven, Christine|||0000-0003-0183-7665, Zetterberg, Henrik|||0000-0003-3930-4354, Nellgård, Bengt, Blennow, Kaj|||0000-0002-1890-4193, Crispin, Alexander, Ewers, Michael|||0000-0001-5231-1714, Haass, Christian|||0000-0002-4869-1627
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:185818
Acceso en línea:https://ddd.uab.cat/record/185818
https://dx.doi.org/urn:doi:10.15252/emmm.201506123
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Biomarkers
Microglia
Neurodegeneration
TREM2
Biomarkers & Diagnostic Imaging
Neuroscience
Descripción
Sumario:2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). In this cross-sectional multicenter study, we investigated whether levels of 2 are changed during the clinical course of , and in cognitively normal individuals with suspected non- pathology (). 2 levels were higher in mild cognitive impairment due to than in all other groups and controls. individuals also had significantly increased 2 compared to controls. Moreover, increased 2 levels were associated with higher total tau and phospho-tau, which are markers of neuronal degeneration and tau pathology. Our data demonstrate that 2 levels are increased in the early symptomatic phase of , probably reflecting a corresponding change of the microglia activation status in response to neuronal degeneration.

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