Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study

Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization da...

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Autores: Martinez-Solano, J, Gutierrez-Ibanes, E, Ortiz-Bautista, C, Garcia-Cosio, MD, Sarnago-Cebada, F, Diaz-Molina, B, Pascual, I, Oteo-Dominguez, JF, Gomez-Bueno, M, Calvino-Santos, R, Crespo-Leiro, MG, Gomez-Hospital, JA, Diez-Lopez, C, Garcia-Lara, J, Garrido-Bravo, IP, de la Fuente-Galan, L, Lopez-Diaz, J, Mirabet-Perez, S, Martinez-Selles, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p15605
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15605
https://ddd.uab.cat/record/283196
Access Level:acceso abierto
Palabra clave:pulmonary hypertension
pulmonary vascular remodeling
advanced heart failure
optical coherence tomography
intravascular imaging
right heart catheterization
heart transplant
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spelling Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF StudyMartinez-Solano, JGutierrez-Ibanes, EOrtiz-Bautista, CGarcia-Cosio, MDSarnago-Cebada, FDiaz-Molina, BPascual, IOteo-Dominguez, JFGomez-Bueno, MCalvino-Santos, RCrespo-Leiro, MGGomez-Hospital, JADiez-Lopez, CGarcia-Lara, JGarrido-Bravo, IPde la Fuente-Galan, LLopez-Diaz, JMirabet-Perez, SMartinez-Selles, Mpulmonary hypertensionpulmonary vascular remodelingadvanced heart failureoptical coherence tomographyintravascular imagingright heart catheterizationheart transplantObjective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3-50.0 vs. 47.0 mmHg, IQR 34.6-59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3-3.7 vs. 2.0 Wood units, IQR 1.4-3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 +/- 0.5 mm vs. 0.2 +/- 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15605https://ddd.uab.cat/record/283196Journal of Cardiovascular Development and DiseaseISSN: 23083425reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p156052026-06-14T12:41:47Z
dc.title.none.fl_str_mv Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
spellingShingle Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
Martinez-Solano, J
pulmonary hypertension
pulmonary vascular remodeling
advanced heart failure
optical coherence tomography
intravascular imaging
right heart catheterization
heart transplant
title_short Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_full Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_fullStr Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_full_unstemmed Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
title_sort Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study
dc.creator.none.fl_str_mv Martinez-Solano, J
Gutierrez-Ibanes, E
Ortiz-Bautista, C
Garcia-Cosio, MD
Sarnago-Cebada, F
Diaz-Molina, B
Pascual, I
Oteo-Dominguez, JF
Gomez-Bueno, M
Calvino-Santos, R
Crespo-Leiro, MG
Gomez-Hospital, JA
Diez-Lopez, C
Garcia-Lara, J
Garrido-Bravo, IP
de la Fuente-Galan, L
Lopez-Diaz, J
Mirabet-Perez, S
Martinez-Selles, M
author Martinez-Solano, J
author_facet Martinez-Solano, J
Gutierrez-Ibanes, E
Ortiz-Bautista, C
Garcia-Cosio, MD
Sarnago-Cebada, F
Diaz-Molina, B
Pascual, I
Oteo-Dominguez, JF
Gomez-Bueno, M
Calvino-Santos, R
Crespo-Leiro, MG
Gomez-Hospital, JA
Diez-Lopez, C
Garcia-Lara, J
Garrido-Bravo, IP
de la Fuente-Galan, L
Lopez-Diaz, J
Mirabet-Perez, S
Martinez-Selles, M
author_role author
author2 Gutierrez-Ibanes, E
Ortiz-Bautista, C
Garcia-Cosio, MD
Sarnago-Cebada, F
Diaz-Molina, B
Pascual, I
Oteo-Dominguez, JF
Gomez-Bueno, M
Calvino-Santos, R
Crespo-Leiro, MG
Gomez-Hospital, JA
Diez-Lopez, C
Garcia-Lara, J
Garrido-Bravo, IP
de la Fuente-Galan, L
Lopez-Diaz, J
Mirabet-Perez, S
Martinez-Selles, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv pulmonary hypertension
pulmonary vascular remodeling
advanced heart failure
optical coherence tomography
intravascular imaging
right heart catheterization
heart transplant
topic pulmonary hypertension
pulmonary vascular remodeling
advanced heart failure
optical coherence tomography
intravascular imaging
right heart catheterization
heart transplant
description Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3-50.0 vs. 47.0 mmHg, IQR 34.6-59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3-3.7 vs. 2.0 Wood units, IQR 1.4-3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 +/- 0.5 mm vs. 0.2 +/- 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15605
https://ddd.uab.cat/record/283196
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15605
https://ddd.uab.cat/record/283196
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Cardiovascular Development and Disease
ISSN: 23083425
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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