Carboxylate-Assisted Formation of Aryl-Co(III) Masked-Carbenes in Cobalt-Catalyzed C-H Functionalization with Diazo Esters
Herein we describe the synthesis of a family of aryl-Co(III)-carboxylate complexes and their reactivity with ethyl di-azoacetate (EDA). Crystallographic, full spectroscopic characterization and theoretical evidence of unique C-metalated aryl-Co(III) enolate intermediates is provided, unraveling a ca...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10256/16598 |
| Acceso en línea: | http://hdl.handle.net/10256/16598 |
| Access Level: | acceso abierto |
| Palabra clave: | Reaccions químiques regioselectives Chemical reactions Compostos orgànics -- Síntesi Organic compounds -- Synthesis |
| Sumario: | Herein we describe the synthesis of a family of aryl-Co(III)-carboxylate complexes and their reactivity with ethyl di-azoacetate (EDA). Crystallographic, full spectroscopic characterization and theoretical evidence of unique C-metalated aryl-Co(III) enolate intermediates is provided, unraveling a carboxylate-assisted formation of aryl-Co(III) masked-carbenes. Moreover, additional evidence for an unprecedented Co(III)-mediated intramolecular SN2-type C-C bond formation in which the carboxylate moiety acts as a relay is disclosed. This novel strategy is key to tame the hot reactivity of a metastable Co(III)-carbene and elicit C-C coupling products in a productive manner |
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