Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and...

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Autores: Górriz, José L., Arroyo, David, D’Marco, Luis, Torra, Roser, Tomás, Patricia, Puchades, María Jesús, Panizo, Nayara, Pantoja, Jonay, Montomoli, Marco, Llisterri, José Luis, Pallares Carratalá, Vicente, Valdivielso Revilla, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/72365
Acceso en línea:https://doi.org/10.1186/s12882-021-02313-1
http://hdl.handle.net/10459.1/72365
Access Level:acceso abierto
Palabra clave:Autosomal dominant polycystic kidney disease
Chronic kidney disease
Cardiovascular disease
Nephropathy
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spelling Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney diseaseGórriz, José L.Arroyo, DavidD’Marco, LuisTorra, RoserTomás, PatriciaPuchades, María JesúsPanizo, NayaraPantoja, JonayMontomoli, MarcoLlisterri, José LuisPallares Carratalá, VicenteValdivielso Revilla, José ManuelAutosomal dominant polycystic kidney diseaseChronic kidney diseaseCardiovascular diseaseNephropathyBackground: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and cardiovascular events (CVE) in ADPKD and their relations with asymptomatic CVD in CKD from other etiologies (CKDoe) and controls. Methods: We evaluated 2445 CKD patients (2010–2012). The information collected was: clinical, anthropometric and analytical parameters, treatments and CVD evaluation (intima-media thickness (IMT), atheromatous plaque presence and ankle-brachial index (ABI)). Laboratory, vital status, CVE and hospitalizations were collected for 4 years. Results: ADPKD patients had a worse renal function and worst achievement of blood pressure, higher parathormone levels but lower proteinuria compared to CKDoe. ADPKD patients presented lower IMT values than other groups, however, an intermediate rate of pathologic ABI and atheromatous plaque was present. More than half of the patients received statins, achieving LDL-c levels < 100 only in 50 and 39.8% of them (ADPKD and CKDoe respectively). The number of CVE during the follow-up period was low. In adjusted Cox regression model, ADPDK had the lowest occurrence of CVE of all three groups (HR:0.422, 95%CI 0.221–0.808, p = 0.009). Conclusion: ADPKD patients show intermediate control rates of CVD. A better control of CVD risk seems to be related with a lower load of CVD compared to other groups, which may lead in the long term to a better prognosis. Further investigation is necessary to determine cardiovascular prognosis in ADPKD.The NEFRONA study is funded by a research grant from AbbVie and the Spanish government RETIC (RD12/0021) and FIS PS10/00946. Torra R research is funded by the Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER) funds, RETIC REDINREN RD16/0009 FIS FEDER FUNDS (PI15/01824, PI18/00362).BMC202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1186/s12882-021-02313-1http://hdl.handle.net/10459.1/72365http://hdl.handle.net/10459.1/72365reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1186/s12882-021-02313-1BMC Nephrology, 2021, vol. 22, 110cc-by (c) Gorriz et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/723652026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
title Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
spellingShingle Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
Górriz, José L.
Autosomal dominant polycystic kidney disease
Chronic kidney disease
Cardiovascular disease
Nephropathy
title_short Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
title_full Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
title_fullStr Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
title_full_unstemmed Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
title_sort Cardiovascular risk factors and the impact on prognosis in patients with chronic kidney disease secondary to autosomal dominant polycystic kidney disease
dc.creator.none.fl_str_mv Górriz, José L.
Arroyo, David
D’Marco, Luis
Torra, Roser
Tomás, Patricia
Puchades, María Jesús
Panizo, Nayara
Pantoja, Jonay
Montomoli, Marco
Llisterri, José Luis
Pallares Carratalá, Vicente
Valdivielso Revilla, José Manuel
author Górriz, José L.
author_facet Górriz, José L.
Arroyo, David
D’Marco, Luis
Torra, Roser
Tomás, Patricia
Puchades, María Jesús
Panizo, Nayara
Pantoja, Jonay
Montomoli, Marco
Llisterri, José Luis
Pallares Carratalá, Vicente
Valdivielso Revilla, José Manuel
author_role author
author2 Arroyo, David
D’Marco, Luis
Torra, Roser
Tomás, Patricia
Puchades, María Jesús
Panizo, Nayara
Pantoja, Jonay
Montomoli, Marco
Llisterri, José Luis
Pallares Carratalá, Vicente
Valdivielso Revilla, José Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Autosomal dominant polycystic kidney disease
Chronic kidney disease
Cardiovascular disease
Nephropathy
topic Autosomal dominant polycystic kidney disease
Chronic kidney disease
Cardiovascular disease
Nephropathy
description Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary renal disease. There is an increased rate of cardiovascular disease (CVD) in ADPKD. In this study, we evaluate the prevalence of cardiovascular risk factors, the achievement rates for treatment goals and cardiovascular events (CVE) in ADPKD and their relations with asymptomatic CVD in CKD from other etiologies (CKDoe) and controls. Methods: We evaluated 2445 CKD patients (2010–2012). The information collected was: clinical, anthropometric and analytical parameters, treatments and CVD evaluation (intima-media thickness (IMT), atheromatous plaque presence and ankle-brachial index (ABI)). Laboratory, vital status, CVE and hospitalizations were collected for 4 years. Results: ADPKD patients had a worse renal function and worst achievement of blood pressure, higher parathormone levels but lower proteinuria compared to CKDoe. ADPKD patients presented lower IMT values than other groups, however, an intermediate rate of pathologic ABI and atheromatous plaque was present. More than half of the patients received statins, achieving LDL-c levels < 100 only in 50 and 39.8% of them (ADPKD and CKDoe respectively). The number of CVE during the follow-up period was low. In adjusted Cox regression model, ADPDK had the lowest occurrence of CVE of all three groups (HR:0.422, 95%CI 0.221–0.808, p = 0.009). Conclusion: ADPKD patients show intermediate control rates of CVD. A better control of CVD risk seems to be related with a lower load of CVD compared to other groups, which may lead in the long term to a better prognosis. Further investigation is necessary to determine cardiovascular prognosis in ADPKD.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1186/s12882-021-02313-1
http://hdl.handle.net/10459.1/72365
http://hdl.handle.net/10459.1/72365
url https://doi.org/10.1186/s12882-021-02313-1
http://hdl.handle.net/10459.1/72365
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1186/s12882-021-02313-1
BMC Nephrology, 2021, vol. 22, 110
dc.rights.none.fl_str_mv cc-by (c) Gorriz et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Gorriz et al., 2021
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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