Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study

Biomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic ris...

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Autores: Unión-Caballero, Andrea, Meroño, Tomás, Zamora-Ros, Raul, Linn Rostgaard-Hansen, Agneta, Miñarro Alonso, Antonio, Sànchez, Àlex (Sànchez Pla), Estanyol-Torres, Núria, Martínez Huélamo, Miriam, Cubedo Culleré, Marta, González-Domínguez, Raúl, Tjønneland, Anne, Riccardi, Gabrielle, Landberg, Rikard, Halkjær, Jytte, Andrés Lacueva, Ma. Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/208129
Acceso en línea:https://hdl.handle.net/2445/208129
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Metabòlits
Fibres
Biochemical markers
Metabolites
Fibers
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spelling Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX studyUnión-Caballero, AndreaMeroño, TomásZamora-Ros, RaulLinn Rostgaard-Hansen, AgnetaMiñarro Alonso, AntonioSànchez, Àlex (Sànchez Pla)Estanyol-Torres, NúriaMartínez Huélamo, MiriamCubedo Culleré, MartaGonzález-Domínguez, RaúlTjønneland, AnneRiccardi, GabrielleLandberg, RikardHalkjær, JytteAndrés Lacueva, Ma. CristinaMarcadors bioquímicsMetabòlitsFibresBiochemical markersMetabolitesFibersBiomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic risk factors. We used data and samples from the Danish Diet Cancer and Health Next Generation (DCH-NG) MAX-study, a one-year observational study with evaluations at baseline, six and 12 months (n = 624, 55% female, mean age: 43 years, 1353 observations). Direct associations between fibre intake and plasma concentrations of 2,6-dihydroxybenzoic acid (2,6-DHBA) and indolepropionic acid were observed at the three time-points. Both metabolites showed an intraclass-correlation coefficient (ICC) > 0.50 and were associated with the self-reported intake of wholegrain cereals, and of fruits and vegetables, respectively. Other metabolites associated with dietary fibre intake were linolenoyl carnitine, 2-aminophenol, 3,4-DHBA, and proline betaine. Based on the metabolites associated with dietary fibre intake we calculated predicted values of fibre intake using a multivariate, machine-learning algorithm. Metabolomics-based predicted fibre, but not self-reported fibre values, showed negative associations with cardiometabolic risk factors (i.e. high sensitivity C-reactive protein, systolic and diastolic blood pressure, all FDR-adjusted p-values <0.05). Furthermore, different correlations with gut microbiota composition were observed. In conclusion, 2,6-DHBA and indolepropionic acid in plasma may better link dietary fibre intake with its metabolic effects than self-reported values. These metabolites may represent a novel class of biomarkers reflecting both dietary exposure and host and/or gut microbiota characteristics providing a read-out that is differentially related to cardiometabolic risk.Royal Society of Chemistry2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/208129Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1039/D3FO04763FFood & Function, 2024, num.15, p. 1643-1654https://doi.org/10.1039/D3FO04763Fcc-by-nc (c) Unión-Caballero, A. et al., 2024http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2081292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
title Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
spellingShingle Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
Unión-Caballero, Andrea
Marcadors bioquímics
Metabòlits
Fibres
Biochemical markers
Metabolites
Fibers
title_short Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
title_full Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
title_fullStr Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
title_full_unstemmed Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
title_sort Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
dc.creator.none.fl_str_mv Unión-Caballero, Andrea
Meroño, Tomás
Zamora-Ros, Raul
Linn Rostgaard-Hansen, Agneta
Miñarro Alonso, Antonio
Sànchez, Àlex (Sànchez Pla)
Estanyol-Torres, Núria
Martínez Huélamo, Miriam
Cubedo Culleré, Marta
González-Domínguez, Raúl
Tjønneland, Anne
Riccardi, Gabrielle
Landberg, Rikard
Halkjær, Jytte
Andrés Lacueva, Ma. Cristina
author Unión-Caballero, Andrea
author_facet Unión-Caballero, Andrea
Meroño, Tomás
Zamora-Ros, Raul
Linn Rostgaard-Hansen, Agneta
Miñarro Alonso, Antonio
Sànchez, Àlex (Sànchez Pla)
Estanyol-Torres, Núria
Martínez Huélamo, Miriam
Cubedo Culleré, Marta
González-Domínguez, Raúl
Tjønneland, Anne
Riccardi, Gabrielle
Landberg, Rikard
Halkjær, Jytte
Andrés Lacueva, Ma. Cristina
author_role author
author2 Meroño, Tomás
Zamora-Ros, Raul
Linn Rostgaard-Hansen, Agneta
Miñarro Alonso, Antonio
Sànchez, Àlex (Sànchez Pla)
Estanyol-Torres, Núria
Martínez Huélamo, Miriam
Cubedo Culleré, Marta
González-Domínguez, Raúl
Tjønneland, Anne
Riccardi, Gabrielle
Landberg, Rikard
Halkjær, Jytte
Andrés Lacueva, Ma. Cristina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Metabòlits
Fibres
Biochemical markers
Metabolites
Fibers
topic Marcadors bioquímics
Metabòlits
Fibres
Biochemical markers
Metabolites
Fibers
description Biomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic risk factors. We used data and samples from the Danish Diet Cancer and Health Next Generation (DCH-NG) MAX-study, a one-year observational study with evaluations at baseline, six and 12 months (n = 624, 55% female, mean age: 43 years, 1353 observations). Direct associations between fibre intake and plasma concentrations of 2,6-dihydroxybenzoic acid (2,6-DHBA) and indolepropionic acid were observed at the three time-points. Both metabolites showed an intraclass-correlation coefficient (ICC) > 0.50 and were associated with the self-reported intake of wholegrain cereals, and of fruits and vegetables, respectively. Other metabolites associated with dietary fibre intake were linolenoyl carnitine, 2-aminophenol, 3,4-DHBA, and proline betaine. Based on the metabolites associated with dietary fibre intake we calculated predicted values of fibre intake using a multivariate, machine-learning algorithm. Metabolomics-based predicted fibre, but not self-reported fibre values, showed negative associations with cardiometabolic risk factors (i.e. high sensitivity C-reactive protein, systolic and diastolic blood pressure, all FDR-adjusted p-values <0.05). Furthermore, different correlations with gut microbiota composition were observed. In conclusion, 2,6-DHBA and indolepropionic acid in plasma may better link dietary fibre intake with its metabolic effects than self-reported values. These metabolites may represent a novel class of biomarkers reflecting both dietary exposure and host and/or gut microbiota characteristics providing a read-out that is differentially related to cardiometabolic risk.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208129
url https://hdl.handle.net/2445/208129
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1039/D3FO04763F
Food & Function, 2024, num.15, p. 1643-1654
https://doi.org/10.1039/D3FO04763F
dc.rights.none.fl_str_mv cc-by-nc (c) Unión-Caballero, A. et al., 2024
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Unión-Caballero, A. et al., 2024
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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