Macronutrient quality and all-cause mortality in the SUN cohort

No previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (Unive...

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Authors: Santiago-Neri, S. (Susana)|||/items/d75cc58b-f5a6-4554-8f58-890457b895e1, Zazpe, I. (Itziar)|||/items/d9449b46-6bda-41b6-8f4b-418cb1800ec6, Fernández-Lázaro, C.I. (César Ignacio)|||/items/7733df60-158c-4de1-a1df-bc693f6f1f40, De-la-O-Pascual, V. (Víctor)|||/items/eb2155ad-a4a6-4ddf-93ae-7bc9e0b133d5, Bes-Rastrollo, M. (Maira)|||/items/d46c05fd-209a-4259-90c6-07202d4c72af, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Format: article
Publication Date:2021
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/115283
Online Access:https://hdl.handle.net/10171/115283
Access Level:Open access
Keyword:SUN cohort
All-cause mortality
Carbohydrates
Fat
Macronutrient quality
Proteins
Description
Summary:No previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (University of Navarra Follow-Up) study, a Mediterranean cohort of middle-aged adults. Dietary intake information was obtained from a validated 136-item semi-quantitative food-frequency questionnaire. We calculated the MQI (categorized in quartiles) based on three quality indexes: the carbohydrate quality index (CQI), the fat quality index (FQI), and the healthy plate protein source quality index (HPPQI). Among 19,083 participants (mean age 38.4, 59.9% female), 440 deaths from all causes were observed during a median follow-up of 12.2 years (IQR, 8.3-14.9). No significant association was found between the MQI and mortality risk with multivariable-adjusted hazard ratio (HR) for the highest vs. the lowest quartile of 0.79 (95% CI, 0.59-1.06; Ptrend = 0.199). The CQI was the only component of the MQI associated with mortality showing a significant inverse relationship, with HR between extreme quartiles of 0.64 (95% CI, 0.45-0.90; Ptrend = 0.021). In this Mediterranean cohort, a new and multidimensional MQI defined a priori was not associated with all-cause mortality. Among its three sub-indexes, only the CQI showed a significant inverse relationship with the risk of all-cause mortality.

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