Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging

Head-Down Bed Rest (HDBR) microgravity simulation induces cardiovascular deconditioning, including effects on ventricular repolarization. The index of Periodic Repolarization Dynamics (PRD) was developed to quantify low-frequency oscillations of cardiac repolarization. In this study, PRD was quantif...

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Autores: Palacios, S., Caiani, E.G., Pueyo, E., Martínez, J.P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:98279
Acceso en línea:http://zaguan.unizar.es/record/98279
Access Level:acceso abierto
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spelling Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal AveragingPalacios, S.Caiani, E.G.Pueyo, E.Martínez, J.P.Head-Down Bed Rest (HDBR) microgravity simulation induces cardiovascular deconditioning, including effects on ventricular repolarization. The index of Periodic Repolarization Dynamics (PRD) was developed to quantify low-frequency oscillations of cardiac repolarization. In this study, PRD was quantified by Phase Rectified Signal Averaging (PRDPRSA) and Continuous Wavelet Transform (PRDCWT) methods. PRD was analyzed in ECGs from 22 volunteers at rest and during orthostatic Tilt-Table Test (TTT) performed before and after -6° 60-days HDBR. Significant correlation was found between PRD measured by PRSA and CWT (Pearson''s ¿ = 0.93, p < 10-54 and Kendall''s t = 0.79 p < 10-38). A highly significant increase was found when PRDPRSA values were measured at POST-HDBR with respect to PRE-HDBR in the tilt phase: 1.40 [1.10] deg and 0.97 [0.90] deg (median [IQR]), p = 0.008, respectively. PRDPRSA also increased significantly in the tilt phase with respect to baseline, both at POST-HDBR (0.90 [0.57] deg, p = 0.003) and at PRE-HDBR (0.75 [0.45] deg, p = 0.011). PRD, either measured with PRSA or with CWT, is able to measure changes in ventricular repolarization induced by microgravity simulation as well as following sympathetic provocation.2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/98279reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoSinfo:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284/info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-Rinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:982792026-05-29T13:59:51Z
dc.title.none.fl_str_mv Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
title Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
spellingShingle Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
Palacios, S.
title_short Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
title_full Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
title_fullStr Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
title_full_unstemmed Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
title_sort Response of Ventricular Repolarization to Simulated Microgravity Measured by Periodic Repolarization Dynamics Using Phase-Rectified Signal Averaging
dc.creator.none.fl_str_mv Palacios, S.
Caiani, E.G.
Pueyo, E.
Martínez, J.P.
author Palacios, S.
author_facet Palacios, S.
Caiani, E.G.
Pueyo, E.
Martínez, J.P.
author_role author
author2 Caiani, E.G.
Pueyo, E.
Martínez, J.P.
author2_role author
author
author
description Head-Down Bed Rest (HDBR) microgravity simulation induces cardiovascular deconditioning, including effects on ventricular repolarization. The index of Periodic Repolarization Dynamics (PRD) was developed to quantify low-frequency oscillations of cardiac repolarization. In this study, PRD was quantified by Phase Rectified Signal Averaging (PRDPRSA) and Continuous Wavelet Transform (PRDCWT) methods. PRD was analyzed in ECGs from 22 volunteers at rest and during orthostatic Tilt-Table Test (TTT) performed before and after -6° 60-days HDBR. Significant correlation was found between PRD measured by PRSA and CWT (Pearson''s ¿ = 0.93, p < 10-54 and Kendall''s t = 0.79 p < 10-38). A highly significant increase was found when PRDPRSA values were measured at POST-HDBR with respect to PRE-HDBR in the tilt phase: 1.40 [1.10] deg and 0.97 [0.90] deg (median [IQR]), p = 0.008, respectively. PRDPRSA also increased significantly in the tilt phase with respect to baseline, both at POST-HDBR (0.90 [0.57] deg, p = 0.003) and at PRE-HDBR (0.75 [0.45] deg, p = 0.011). PRD, either measured with PRSA or with CWT, is able to measure changes in ventricular repolarization induced by microgravity simulation as well as following sympathetic provocation.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/98279
url http://zaguan.unizar.es/record/98279
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS
info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284/
info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-R
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv
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dc.source.none.fl_str_mv reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza
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instname_str Universidad de Zaragoza
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collection Zaguán. Repositorio Digital de la Universidad de Zaragoza
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