Electronegative LDL
Electronegative low density lipoprotein (LDL(-)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms....
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:303282 |
| Acceso en línea: | https://ddd.uab.cat/record/303282 https://dx.doi.org/urn:doi:10.1155/2013/181324 |
| Access Level: | acceso abierto |
| Palabra clave: | Animals Anti-Inflammatory Agents Apoptosis Atherosclerosis Endothelial Cells Humans Inflammation Leukocytes Ligands Lipopolysaccharides Lipoproteins, LDL Monocytes Oxygen |
| Sumario: | Electronegative low density lipoprotein (LDL(-)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(-) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(-) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(-) suggest that it could have a dual biological effect. © 2013 Montserrat Estruch et al. |
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