Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease

Background: The course of acute Vogt-Koyanagi-Harada is typically assessed qualitatively using indocyanine green angiography. Swept-source optical coherence tomography may provide a safer, non-invasive, more objective approach to follow up. In this study, we assess the clinical value of the automate...

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Autores: Garcia Garcia, Olga, Jordán-Cumplido, Sara, Subirá-González, Olaia, García Bru, Pere, Arias Barquet, Lluís, Caminal Mitjana, Josep Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218330
Acceso en línea:https://hdl.handle.net/2445/218330
Access Level:acceso abierto
Palabra clave:Coroide
Malalties autoimmunitàries
Tomografia de coherència òptica
Choroid
Autoimmune diseases
Optical coherence tomography
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spelling Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada diseaseGarcia Garcia, OlgaJordán-Cumplido, SaraSubirá-González, OlaiaGarcía Bru, PereArias Barquet, LluísCaminal Mitjana, Josep MariaCoroideMalalties autoimmunitàriesTomografia de coherència òpticaChoroidAutoimmune diseasesOptical coherence tomographyBackground: The course of acute Vogt-Koyanagi-Harada is typically assessed qualitatively using indocyanine green angiography. Swept-source optical coherence tomography may provide a safer, non-invasive, more objective approach to follow up. In this study, we assess the clinical value of the automated measurement capabilities of swept-source tomography to measure choroidal thickness. Design: Prospective, longitudinal case-control study at a tertiary university hospital. Participants: Nine patients with acute Vogt-Koyanagi-Harada disease (18 eyes) and 17 age-matched controls (34 eyes). Methods: Choroidal thickness (subfoveal area and ETDRS grid) was automatically measured with swept-source optical coherence tomography. Changes in thickness were compared to changes in visual acuity and indocyanine green angiography findings to check for correlations. Main outcome measures: Changes in choroidal thickness (micrometers- μm) from baseline. Secondary measures included visual acuity and angiography. Results: At baseline, patients presented significantly greater mean (SD) subfoveal choroidal thickness (666.9 μm [258.3] vs. 302.3 [71.4]) and ETDRS grid choroidal thickness (648.7 μm [260.5] vs. 287.5 [69.3]) than controls (p=0.000). Choroidal thinning and improved vision were associated with treatment while increasing thickness and worsening vision were associated with posterior relapse. In 62.5% of recurrences in tomography, no changes in visual acuity were present; however, all recurrences diagnosed with tomography showed signs of inflammation on angiography. Conclusions: Automatic measurement of choroidal thickness with swept-source optical coherence tomography is a rapid, non-invasive manner of detecting posterior segment recurrences and treatment response in acute Harada patients. Swept-source tomography could reduce the need for angiography to monitor patients with Harada disease.Longdom Publishing2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/218330Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.4172/2155-9570.1000579Journal of Clinical and Experimental Ophthalmology, 2016, vol. 7, num.4https://doi.org/10.4172/2155-9570.1000579cc-by (c) García-García, O. et al., 2016http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2183302026-05-27T06:46:51Z
dc.title.none.fl_str_mv Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
title Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
spellingShingle Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
Garcia Garcia, Olga
Coroide
Malalties autoimmunitàries
Tomografia de coherència òptica
Choroid
Autoimmune diseases
Optical coherence tomography
title_short Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
title_full Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
title_fullStr Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
title_full_unstemmed Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
title_sort Automatic measurement of choroidal thickness with swept-source optical coherence tomography for clinical follow-up in acute Vogt-Koyanagi-Harada disease
dc.creator.none.fl_str_mv Garcia Garcia, Olga
Jordán-Cumplido, Sara
Subirá-González, Olaia
García Bru, Pere
Arias Barquet, Lluís
Caminal Mitjana, Josep Maria
author Garcia Garcia, Olga
author_facet Garcia Garcia, Olga
Jordán-Cumplido, Sara
Subirá-González, Olaia
García Bru, Pere
Arias Barquet, Lluís
Caminal Mitjana, Josep Maria
author_role author
author2 Jordán-Cumplido, Sara
Subirá-González, Olaia
García Bru, Pere
Arias Barquet, Lluís
Caminal Mitjana, Josep Maria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Coroide
Malalties autoimmunitàries
Tomografia de coherència òptica
Choroid
Autoimmune diseases
Optical coherence tomography
topic Coroide
Malalties autoimmunitàries
Tomografia de coherència òptica
Choroid
Autoimmune diseases
Optical coherence tomography
description Background: The course of acute Vogt-Koyanagi-Harada is typically assessed qualitatively using indocyanine green angiography. Swept-source optical coherence tomography may provide a safer, non-invasive, more objective approach to follow up. In this study, we assess the clinical value of the automated measurement capabilities of swept-source tomography to measure choroidal thickness. Design: Prospective, longitudinal case-control study at a tertiary university hospital. Participants: Nine patients with acute Vogt-Koyanagi-Harada disease (18 eyes) and 17 age-matched controls (34 eyes). Methods: Choroidal thickness (subfoveal area and ETDRS grid) was automatically measured with swept-source optical coherence tomography. Changes in thickness were compared to changes in visual acuity and indocyanine green angiography findings to check for correlations. Main outcome measures: Changes in choroidal thickness (micrometers- μm) from baseline. Secondary measures included visual acuity and angiography. Results: At baseline, patients presented significantly greater mean (SD) subfoveal choroidal thickness (666.9 μm [258.3] vs. 302.3 [71.4]) and ETDRS grid choroidal thickness (648.7 μm [260.5] vs. 287.5 [69.3]) than controls (p=0.000). Choroidal thinning and improved vision were associated with treatment while increasing thickness and worsening vision were associated with posterior relapse. In 62.5% of recurrences in tomography, no changes in visual acuity were present; however, all recurrences diagnosed with tomography showed signs of inflammation on angiography. Conclusions: Automatic measurement of choroidal thickness with swept-source optical coherence tomography is a rapid, non-invasive manner of detecting posterior segment recurrences and treatment response in acute Harada patients. Swept-source tomography could reduce the need for angiography to monitor patients with Harada disease.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/218330
url https://hdl.handle.net/2445/218330
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.4172/2155-9570.1000579
Journal of Clinical and Experimental Ophthalmology, 2016, vol. 7, num.4
https://doi.org/10.4172/2155-9570.1000579
dc.rights.none.fl_str_mv cc-by (c) García-García, O. et al., 2016
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) García-García, O. et al., 2016
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Longdom Publishing
publisher.none.fl_str_mv Longdom Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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