Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria

Physiological and histochemical studies have recently supported the notion that nitric oxide (NO) is the transduction signal responsible for the non-adrenergic, non-cholinergic relaxation of the vasculature as well as the airways of the mammalian lung. We report the presence of immunoreactivity to N...

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Autores: Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a, Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119, Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596, Moncada, S. (S.)|||/items/92da4ca6-ebec-45a3-95de-eafb63344d02, Moreno, V. (V.)|||/items/37556314-4a70-486f-bfaa-56ef88f4b1a9, Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0
Tipo de recurso: artículo
Fecha de publicación:1995
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/20136
Acceso en línea:https://hdl.handle.net/10171/20136
Access Level:acceso abierto
Palabra clave:Neurons/enzymology
Nitric Oxide Synthase/analysis
Respiratory System/enzymology
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spelling Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporariaBodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56aVillaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596Moncada, S. (S.)|||/items/92da4ca6-ebec-45a3-95de-eafb63344d02Moreno, V. (V.)|||/items/37556314-4a70-486f-bfaa-56ef88f4b1a9Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0Neurons/enzymologyNitric Oxide Synthase/analysisRespiratory System/enzymologyPhysiological and histochemical studies have recently supported the notion that nitric oxide (NO) is the transduction signal responsible for the non-adrenergic, non-cholinergic relaxation of the vasculature as well as the airways of the mammalian lung. We report the presence of immunoreactivity to NO synthase (NOS) in nerve cell bodies and nerve fibres in the neural plexus of the buccal cavity and lungs of the frog, Rana temporaria, using the indirect immunocytochemical technique of avidin-biotin and the NADPH-diaphorase technique. The neural ganglia located next to the muscle layer and within the connective tissue of the buccal cavity were partially immunoreactive for NOS. In the lungs, NOS immunoreactivity occurred in nerve cell bodies, as well as in both myelinated and unmyelinated nerve fibres. Fine nerve fibres immunoreactive to NOS were observed within the muscle fibre bundles and next to the respiratory epithelium. Both the presence of NOS immunoreactivity and the positive histochemical reaction for NADPH-diaphorase in the neural plexus of amphibian respiratory tract suggests a broad evolutionary role for NO as a peripheral neurotransmitter.Springer VerlagDadun. Depósito Académico Digital Universidad de Navarra20112011-12-0519951995-01-0119951995-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20136reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/201362026-06-21T12:47:57Z
dc.title.none.fl_str_mv Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
title Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
spellingShingle Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a
Neurons/enzymology
Nitric Oxide Synthase/analysis
Respiratory System/enzymology
title_short Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
title_full Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
title_fullStr Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
title_full_unstemmed Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
title_sort Neuronal nitric oxide synthase immunoreactivity in the respiratory tract of the frog, Rana temporaria
dc.creator.none.fl_str_mv Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a
Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Moncada, S. (S.)|||/items/92da4ca6-ebec-45a3-95de-eafb63344d02
Moreno, V. (V.)|||/items/37556314-4a70-486f-bfaa-56ef88f4b1a9
Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0
author Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a
author_facet Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a
Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Moncada, S. (S.)|||/items/92da4ca6-ebec-45a3-95de-eafb63344d02
Moreno, V. (V.)|||/items/37556314-4a70-486f-bfaa-56ef88f4b1a9
Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0
author_role author
author2 Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Moncada, S. (S.)|||/items/92da4ca6-ebec-45a3-95de-eafb63344d02
Moreno, V. (V.)|||/items/37556314-4a70-486f-bfaa-56ef88f4b1a9
Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Neurons/enzymology
Nitric Oxide Synthase/analysis
Respiratory System/enzymology
topic Neurons/enzymology
Nitric Oxide Synthase/analysis
Respiratory System/enzymology
description Physiological and histochemical studies have recently supported the notion that nitric oxide (NO) is the transduction signal responsible for the non-adrenergic, non-cholinergic relaxation of the vasculature as well as the airways of the mammalian lung. We report the presence of immunoreactivity to NO synthase (NOS) in nerve cell bodies and nerve fibres in the neural plexus of the buccal cavity and lungs of the frog, Rana temporaria, using the indirect immunocytochemical technique of avidin-biotin and the NADPH-diaphorase technique. The neural ganglia located next to the muscle layer and within the connective tissue of the buccal cavity were partially immunoreactive for NOS. In the lungs, NOS immunoreactivity occurred in nerve cell bodies, as well as in both myelinated and unmyelinated nerve fibres. Fine nerve fibres immunoreactive to NOS were observed within the muscle fibre bundles and next to the respiratory epithelium. Both the presence of NOS immunoreactivity and the positive histochemical reaction for NADPH-diaphorase in the neural plexus of amphibian respiratory tract suggests a broad evolutionary role for NO as a peripheral neurotransmitter.
publishDate 1995
dc.date.none.fl_str_mv 1995
1995-01-01
1995
1995-01-01
2011
2011-12-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/20136
url https://hdl.handle.net/10171/20136
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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