Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression
Surgery alone is curative for most children with localized MYCN-non-amplified neuroblastoma. However, 1015% will develop recurrent loco-regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN-non-amplified neu...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Fundació Sant Joan de Déu |
| Repositorio: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p9818 |
| Acceso en línea: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9818 |
| Access Level: | acceso abierto |
| Palabra clave: | localized neuroblastoma metastatic relapse segmental chromosomal alterations |
| Sumario: | Surgery alone is curative for most children with localized MYCN-non-amplified neuroblastoma. However, 1015% will develop recurrent loco-regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN-non-amplified neuroblastoma will develop disseminated disease. We report two children who presented with favorable biology, localized neuroblastoma and subsequently relapsed with metastatic disease after treatment with surgery. Whole-genome DNA copy number analyses performed on the diagnostic tumors identified 15 (case 1) and 8 (case 2) segmental chromosomal alterations. Further analysis of the prognostic value of whole-genome analysis in children with localized neuroblastoma is warranted. Pediatr Blood Cancer 2013;60:332335. (c) 2012 Wiley Periodicals, Inc. |
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