Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.

Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and traditional cardiovascular risk factors. Objective: Identify classic cardiovascu...

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Autores: Fernández Armenteros, José Manuel, Gómez Arbonés, Javier, Buti, Miquel, Betriu i Bars, M. Àngels, Sanmartín Novell, Verònica, Ortega Bravo, Marta, Martínez Alonso, Montserrat, Garí Marsol, Eloi, Portero Otín, Manuel, Santamaria-Babi, L., Casanova i Seuma, Josep M. (Josep Manel)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/65926
Acceso en línea:https://doi.org/10.1111/jdv.15159
http://hdl.handle.net/10459.1/65926
Access Level:acceso abierto
Palabra clave:Psoriasis
Epidemiology
Metabolic syndrome
Cardiovascular risk factors
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spelling Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.Psoriasis and cardiovascular risk factorsFernández Armenteros, José ManuelGómez Arbonés, JavierButi, MiquelBetriu i Bars, M. ÀngelsSanmartín Novell, VerònicaOrtega Bravo, MartaMartínez Alonso, MontserratGarí Marsol, EloiPortero Otín, ManuelSantamaria-Babi, L.Casanova i Seuma, Josep M. (Josep Manel)PsoriasisEpidemiologyMetabolic syndromeCardiovascular risk factorsAbstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and traditional cardiovascular risk factors. Objective: Identify classic cardiovascular risk factors and metabolic syndrome (MS) in patients with psoriasis, their possible association with its severity and compare it with the non-psoriatic population. Methods: This is an observational and cross-sectional population study in Lleida (Spain) from a joint hospital / primary care database. Results: The database comprised 398,701 individuals. There were 6,868 cases registered as psoriasis (1.7%), and 499 of them (7.3%) were classified as moderate-severe psoriasis. Patients with psoriasis had a higher prevalence of traditional cardiovascular risk factors than non-psoriatic population: diabetes mellitus 2 (13.9% vs 7.4%, OR 2.01), dyslipidemia (28.8% vs 17.4%, OR 1.92), arterial hypertension (31.2% vs 19.0%, OR 1.93), obesity (33.7% vs 28.1%, OR 1.30), altered fasting basal glycaemia (21.4% vs 15.1%, OR 1.54), low cholesterol-HDL (38.1% vs 32.3%, OR 1.29), hypertriglyceridemia (45.7% vs 35.2%, OR 1.55) and high waist circumference (75.7% vs 72.3%, OR 1.19). MS was more prevalent in psoriatic patients (28.3% vs 15.1%, OR 2.21) and cardiovascular risk factors were similar between psoriasis severity groups. Psoriatic patients had a higher prevalence of ischemic heart disease (3.3% vs 1.8%, OR 1.87) and vascular-cerebral accidents (1.8% vs 1.2%, OR 1.55). A model for MS showed a significant non-linear relationship with age and sex, and significant differences between patients with and without psoriasis. Conclusion: We found statistically differences in relation to the prevalence of cardiovascular risk factors, MS and major cardiovascular events in psoriatic patients. However, differences were not seen between psoriasis severity groups. Our work reinforces the need for a multidisciplinary approach and close monitoring of cardiovascular risk factors in these patients to prevent a cardiovascular event.Wiley2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1111/jdv.15159http://hdl.handle.net/10459.1/65926reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió postprint del document publicat a: https://doi.org/10.1111/jdv.15159Journal of the European Academy of Dermatology and Venereology, 2019, vol. 33, núm. 1, p. 128-135(c) European Academy of Dermatology and Venereology, 2018info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/659262026-06-24T12:42:17Z
dc.title.none.fl_str_mv Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
Psoriasis and cardiovascular risk factors
title Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
spellingShingle Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
Fernández Armenteros, José Manuel
Psoriasis
Epidemiology
Metabolic syndrome
Cardiovascular risk factors
title_short Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
title_full Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
title_fullStr Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
title_full_unstemmed Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
title_sort Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.
dc.creator.none.fl_str_mv Fernández Armenteros, José Manuel
Gómez Arbonés, Javier
Buti, Miquel
Betriu i Bars, M. Àngels
Sanmartín Novell, Verònica
Ortega Bravo, Marta
Martínez Alonso, Montserrat
Garí Marsol, Eloi
Portero Otín, Manuel
Santamaria-Babi, L.
Casanova i Seuma, Josep M. (Josep Manel)
author Fernández Armenteros, José Manuel
author_facet Fernández Armenteros, José Manuel
Gómez Arbonés, Javier
Buti, Miquel
Betriu i Bars, M. Àngels
Sanmartín Novell, Verònica
Ortega Bravo, Marta
Martínez Alonso, Montserrat
Garí Marsol, Eloi
Portero Otín, Manuel
Santamaria-Babi, L.
Casanova i Seuma, Josep M. (Josep Manel)
author_role author
author2 Gómez Arbonés, Javier
Buti, Miquel
Betriu i Bars, M. Àngels
Sanmartín Novell, Verònica
Ortega Bravo, Marta
Martínez Alonso, Montserrat
Garí Marsol, Eloi
Portero Otín, Manuel
Santamaria-Babi, L.
Casanova i Seuma, Josep M. (Josep Manel)
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psoriasis
Epidemiology
Metabolic syndrome
Cardiovascular risk factors
topic Psoriasis
Epidemiology
Metabolic syndrome
Cardiovascular risk factors
description Abstract Background: Psoriasis is a very prevalent systemic chronic inflammatory disease. Major cardiovascular events are the main cause of mortality in these patients which suggests an association between psoriasis and traditional cardiovascular risk factors. Objective: Identify classic cardiovascular risk factors and metabolic syndrome (MS) in patients with psoriasis, their possible association with its severity and compare it with the non-psoriatic population. Methods: This is an observational and cross-sectional population study in Lleida (Spain) from a joint hospital / primary care database. Results: The database comprised 398,701 individuals. There were 6,868 cases registered as psoriasis (1.7%), and 499 of them (7.3%) were classified as moderate-severe psoriasis. Patients with psoriasis had a higher prevalence of traditional cardiovascular risk factors than non-psoriatic population: diabetes mellitus 2 (13.9% vs 7.4%, OR 2.01), dyslipidemia (28.8% vs 17.4%, OR 1.92), arterial hypertension (31.2% vs 19.0%, OR 1.93), obesity (33.7% vs 28.1%, OR 1.30), altered fasting basal glycaemia (21.4% vs 15.1%, OR 1.54), low cholesterol-HDL (38.1% vs 32.3%, OR 1.29), hypertriglyceridemia (45.7% vs 35.2%, OR 1.55) and high waist circumference (75.7% vs 72.3%, OR 1.19). MS was more prevalent in psoriatic patients (28.3% vs 15.1%, OR 2.21) and cardiovascular risk factors were similar between psoriasis severity groups. Psoriatic patients had a higher prevalence of ischemic heart disease (3.3% vs 1.8%, OR 1.87) and vascular-cerebral accidents (1.8% vs 1.2%, OR 1.55). A model for MS showed a significant non-linear relationship with age and sex, and significant differences between patients with and without psoriasis. Conclusion: We found statistically differences in relation to the prevalence of cardiovascular risk factors, MS and major cardiovascular events in psoriatic patients. However, differences were not seen between psoriasis severity groups. Our work reinforces the need for a multidisciplinary approach and close monitoring of cardiovascular risk factors in these patients to prevent a cardiovascular event.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1111/jdv.15159
http://hdl.handle.net/10459.1/65926
url https://doi.org/10.1111/jdv.15159
http://hdl.handle.net/10459.1/65926
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/jdv.15159
Journal of the European Academy of Dermatology and Venereology, 2019, vol. 33, núm. 1, p. 128-135
dc.rights.none.fl_str_mv (c) European Academy of Dermatology and Venereology, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) European Academy of Dermatology and Venereology, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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