Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study
Objective: Diffuse idiopathic skeletal hyperostosis (DISH) has been associated with an increased risk of vertebral fracture. To date, no studies have investigated the relationship between DISH and bone microstructure assessed by the trabecular bone score (TBS). Methods: Cross-sectional study, nested...
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/21909 |
| Acesso em linha: | http://hdl.handle.net/10902/21909 |
| Access Level: | acceso abierto |
| Palavra-chave: | Bone Metabolic Deseases Bone Turnover Markers Diffuse Idiopathic Skeletal Hyperostosis Trabecular Bone Score |
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Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort studyPini, Stefanie F.Sgaramella, Giusi AlessiaPariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298Ramos Barrón, María del CarmenOlmos Martínez, José Manuel|||0000-0002-7765-0891Hernández Hernández, José Luis|||0000-0002-6585-8847Bone Metabolic DeseasesBone Turnover MarkersDiffuse Idiopathic Skeletal HyperostosisTrabecular Bone ScoreObjective: Diffuse idiopathic skeletal hyperostosis (DISH) has been associated with an increased risk of vertebral fracture. To date, no studies have investigated the relationship between DISH and bone microstructure assessed by the trabecular bone score (TBS). Methods: Cross-sectional study, nested in a prospective population-based cohort. All men (968) aged?50 years were included. Clinical covariates, DISH, TBS, serum bone turnover markers and bone mineral density (BMD) were analyzed. Results: Mean age of participants was 65 ± 9 years. 207 (21.6%) had DISH. DISH subjects were older, had higher body mass index (BMI) and abdominal perimeter, lower glomerular filtration rate (GFR), and higher prevalence of metabolic syndrome (MetS) than non-DISH (NDISH) subjects. Bone mineral density at the lumbar spine (LS-BMD) was significantly higher in the DISH group. TBS values were 1.317 [1.303-1.331] for DISH and 1.334 [1.327-1.341] for NDISH subjects, after adjusting by age, BMI, abdominal perimeter, arterial hypertension, diabetes mellitus, MetS, GFR, serum alkaline phosphatase (ALP), LS and femoral neck BMD (p = 0.03). Serum ALP levels were higher in DISH subjects, showing an inverse correlation with TBS that remained significant after adjusting by age and BMI. Conclusions: TBS values were significantly lower in men with DISH irrespective of age, BMI and BMD, suggesting that the presence of DISH might be related to a worse trabecular microstructureThe study has been funded by grants from the Instituto de Salud Carlos III (PI18/00762), Ministerio de Ciencia, Innovacion y Universidades, Spain, that included FEDER funds from the EU.ElsevierUniversidad de Cantabria20202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/21909Semin Arthritis Rheum . 2020 Dec;50(6):1521-1524reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/219092026-06-02T12:39:31Z |
| dc.title.none.fl_str_mv |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| title |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| spellingShingle |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study Pini, Stefanie F. Bone Metabolic Deseases Bone Turnover Markers Diffuse Idiopathic Skeletal Hyperostosis Trabecular Bone Score |
| title_short |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| title_full |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| title_fullStr |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| title_full_unstemmed |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| title_sort |
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study |
| dc.creator.none.fl_str_mv |
Pini, Stefanie F. Sgaramella, Giusi Alessia Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298 Ramos Barrón, María del Carmen Olmos Martínez, José Manuel|||0000-0002-7765-0891 Hernández Hernández, José Luis|||0000-0002-6585-8847 |
| author |
Pini, Stefanie F. |
| author_facet |
Pini, Stefanie F. Sgaramella, Giusi Alessia Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298 Ramos Barrón, María del Carmen Olmos Martínez, José Manuel|||0000-0002-7765-0891 Hernández Hernández, José Luis|||0000-0002-6585-8847 |
| author_role |
author |
| author2 |
Sgaramella, Giusi Alessia Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298 Ramos Barrón, María del Carmen Olmos Martínez, José Manuel|||0000-0002-7765-0891 Hernández Hernández, José Luis|||0000-0002-6585-8847 |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad de Cantabria |
| dc.subject.none.fl_str_mv |
Bone Metabolic Deseases Bone Turnover Markers Diffuse Idiopathic Skeletal Hyperostosis Trabecular Bone Score |
| topic |
Bone Metabolic Deseases Bone Turnover Markers Diffuse Idiopathic Skeletal Hyperostosis Trabecular Bone Score |
| description |
Objective: Diffuse idiopathic skeletal hyperostosis (DISH) has been associated with an increased risk of vertebral fracture. To date, no studies have investigated the relationship between DISH and bone microstructure assessed by the trabecular bone score (TBS). Methods: Cross-sectional study, nested in a prospective population-based cohort. All men (968) aged?50 years were included. Clinical covariates, DISH, TBS, serum bone turnover markers and bone mineral density (BMD) were analyzed. Results: Mean age of participants was 65 ± 9 years. 207 (21.6%) had DISH. DISH subjects were older, had higher body mass index (BMI) and abdominal perimeter, lower glomerular filtration rate (GFR), and higher prevalence of metabolic syndrome (MetS) than non-DISH (NDISH) subjects. Bone mineral density at the lumbar spine (LS-BMD) was significantly higher in the DISH group. TBS values were 1.317 [1.303-1.331] for DISH and 1.334 [1.327-1.341] for NDISH subjects, after adjusting by age, BMI, abdominal perimeter, arterial hypertension, diabetes mellitus, MetS, GFR, serum alkaline phosphatase (ALP), LS and femoral neck BMD (p = 0.03). Serum ALP levels were higher in DISH subjects, showing an inverse correlation with TBS that remained significant after adjusting by age and BMI. Conclusions: TBS values were significantly lower in men with DISH irrespective of age, BMI and BMD, suggesting that the presence of DISH might be related to a worse trabecular microstructure |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10902/21909 |
| url |
http://hdl.handle.net/10902/21909 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Semin Arthritis Rheum . 2020 Dec;50(6):1521-1524 reponame:UCrea Repositorio Abierto de la Universidad de Cantabria instname:Universidad de Cantabria (UC) |
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Universidad de Cantabria (UC) |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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UCrea Repositorio Abierto de la Universidad de Cantabria |
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1869409507779543040 |
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15,300719 |