pH-responsive diblock copolymers made of omega-pentadecalactone and ionically charged alpha-amino acids
Two sets of ionically charged polypentadecalactone-polypeptide diblock copolymers (PPDLx-b-PAAy, with x= 15 or 20 and y ranging from 30 to 200), one containing alpha-L-glutamic acid (LGA) and the other containing epsilon-L-lysine (LL), were obtained from their respective precursors with the side gro...
| Autores: | , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2019 |
| País: | España |
| Recursos: | Universitat Politècnica de Catalunya (UPC) |
| Repositório: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglês |
| OAI Identifier: | oai:upcommons.upc.edu:2117/168658 |
| Acesso em linha: | https://hdl.handle.net/2117/168658 https://dx.doi.org/10.1016/j.eurpolymj.2019.109244 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Copolymers Polymacrolactone-polypeptide block copolymers Pentadecalactone Amphiphlilic block copolymers Drud delivery systems Nanoparticles DOX DNA polyplexes Copolímers Àrees temàtiques de la UPC::Enginyeria química |
| Resumo: | Two sets of ionically charged polypentadecalactone-polypeptide diblock copolymers (PPDLx-b-PAAy, with x= 15 or 20 and y ranging from 30 to 200), one containing alpha-L-glutamic acid (LGA) and the other containing epsilon-L-lysine (LL), were obtained from their respective precursors with the side groups of LGA and LL protected as gamma-O-benzyl and epsilon-N-carbobenzoxy, respectively. The copolymers were semicrystalline with the polyester block crystallized in the usual pseudo-rhombic lattice and the polypeptide in the alpha-helix or beta-sheet conformation depending on the amino acid and the length of the block. Copolymers with PAA blocks with y = 80 were water-soluble and they adopted the alpha-helix conformation in the aqueous medium when they are in the nonionized state. Both LGA and LL containing copolymers self-assembled in nanoparticles with a size between 150 and 180 nm in diameter. PPDL-b-PLGA nanoparticles were able to load DOX with an efficiency of ~70% whereas PPDL-b-PLL displayed a noticeable capacity for condensing DNA. In both cases hosting was based on the ionic complexation taking place between the ionized copolymer and the guest compound. Accordingly DOX release rate was found to be noticeably depending on pH. |
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