The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder

Although cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently d...

Descripción completa

Detalles Bibliográficos
Autores: Siqueira Rotenberg, Luisa, Kjærstad, Hanne Lie, Varo Martín, Cristina, Vinberg, Maj, Kessing, Lars Vedel, Lafer, Beny, Miskowiak, Kamilla Woznica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/144261
Acceso en línea:https://hdl.handle.net/11441/144261
https://doi.org/10.1016/j.euroneuro.2023.03.005
Access Level:acceso abierto
Palabra clave:bipolar disorder
emotional cognition
longitudinal
cluster analysis
emotion regulation
id ES_6232833de16f8aa3d1e55d3eebc80513
oai_identifier_str oai:idus.us.es:11441/144261
network_acronym_str ES
network_name_str España
repository_id_str
spelling The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorderSiqueira Rotenberg, LuisaKjærstad, Hanne LieVaro Martín, CristinaVinberg, MajKessing, Lars VedelLafer, BenyMiskowiak, Kamilla Woznicabipolar disorderemotional cognitionlongitudinalcluster analysisemotion regulationAlthough cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently diagnosed BD patients compared to healthy controls (HC). Recently diagnosed BD patients and HC underwent comprehensive emotional and non-emotional testing at baseline and again at follow-up. We employed hierarchical cluster analysis at baseline to identify homogenous emotional cognition subgroups of patients, and changes across the subgroups of BD and HC were assessed with linear mixed-model analyses. We found two emotional cognition subgroups: subgroup 1 (65%, n = 179), showing heightened negative emotional reactivity in neutral and negative social scenarios and faster recognition of emotional facial expressions than HC (ps<0.001, n = 190), and subgroup 2 (35%, n = 96) showing blunted reactivity in positive social scenarios, impaired emotion regulation, poorer recognition of positive and slower recognition of all facial expressions than HC (ps≤.03). Subgroup 1 exhibited normalization of the initial emotional cognition abnormalities in follow-up. In contrast, subgroup 2 showed a lack of improvement in reactivity positively-valenced emotional information. Patients in subgroup 2 presented more and longer mixed episodes during the follow-up time and were more often prescribed lithium. One third of patients display blunted emotional reactivity, impaired emotion regulation abilities and facial expression recognition difficulties also show persistent impairments and poorer course of illness. This subgroup may indicate a need for earlier and more targeted therapeutic interventions.Elsevier2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11441/144261https://doi.org/10.1016/j.euroneuro.2023.03.005reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésEuropean Neuropsychopharmacology, 71, 9-24.https://dx.doi.org/10.1016/j.euroneuro.2023.03.005info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1442612026-06-17T12:51:07Z
dc.title.none.fl_str_mv The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
title The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
spellingShingle The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
Siqueira Rotenberg, Luisa
bipolar disorder
emotional cognition
longitudinal
cluster analysis
emotion regulation
title_short The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
title_full The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
title_fullStr The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
title_full_unstemmed The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
title_sort The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder
dc.creator.none.fl_str_mv Siqueira Rotenberg, Luisa
Kjærstad, Hanne Lie
Varo Martín, Cristina
Vinberg, Maj
Kessing, Lars Vedel
Lafer, Beny
Miskowiak, Kamilla Woznica
author Siqueira Rotenberg, Luisa
author_facet Siqueira Rotenberg, Luisa
Kjærstad, Hanne Lie
Varo Martín, Cristina
Vinberg, Maj
Kessing, Lars Vedel
Lafer, Beny
Miskowiak, Kamilla Woznica
author_role author
author2 Kjærstad, Hanne Lie
Varo Martín, Cristina
Vinberg, Maj
Kessing, Lars Vedel
Lafer, Beny
Miskowiak, Kamilla Woznica
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv bipolar disorder
emotional cognition
longitudinal
cluster analysis
emotion regulation
topic bipolar disorder
emotional cognition
longitudinal
cluster analysis
emotion regulation
description Although cross-sectional studies show heterogeneity in emotional cognition in bipolar disorder (BD), the temporal course within subgroups is unclear. In this prospective, longitudinal study we assessed the trajectories of emotional cognition subgroups within a 16-month follow-up period in recently diagnosed BD patients compared to healthy controls (HC). Recently diagnosed BD patients and HC underwent comprehensive emotional and non-emotional testing at baseline and again at follow-up. We employed hierarchical cluster analysis at baseline to identify homogenous emotional cognition subgroups of patients, and changes across the subgroups of BD and HC were assessed with linear mixed-model analyses. We found two emotional cognition subgroups: subgroup 1 (65%, n = 179), showing heightened negative emotional reactivity in neutral and negative social scenarios and faster recognition of emotional facial expressions than HC (ps<0.001, n = 190), and subgroup 2 (35%, n = 96) showing blunted reactivity in positive social scenarios, impaired emotion regulation, poorer recognition of positive and slower recognition of all facial expressions than HC (ps≤.03). Subgroup 1 exhibited normalization of the initial emotional cognition abnormalities in follow-up. In contrast, subgroup 2 showed a lack of improvement in reactivity positively-valenced emotional information. Patients in subgroup 2 presented more and longer mixed episodes during the follow-up time and were more often prescribed lithium. One third of patients display blunted emotional reactivity, impaired emotion regulation abilities and facial expression recognition difficulties also show persistent impairments and poorer course of illness. This subgroup may indicate a need for earlier and more targeted therapeutic interventions.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/144261
https://doi.org/10.1016/j.euroneuro.2023.03.005
url https://hdl.handle.net/11441/144261
https://doi.org/10.1016/j.euroneuro.2023.03.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Neuropsychopharmacology, 71, 9-24.
https://dx.doi.org/10.1016/j.euroneuro.2023.03.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409478414172160
score 15,300719

Similares en LA Referencia