Estudios lipidómicos en macrófagos. Regulación de los niveles lipídicos por lipinas y su impacto en la biología del macrófago y en procesos inflamatorios
This work consists of the description of the lipid profile of different cellular systems, mainly macrophages, in which a key lipid metabolism enzyme, lipin-2, is not present. It has been studied using different techniques, mainly mass spectrometry, how the lack of lipin-2 affects the levels of the d...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Valladolid |
| Repositorio: | UVaDOC. Repositorio Documental de la Universidad de Valladolid |
| OAI Identifier: | oai:uvadoc.uva.es:10324/63677 |
| Acceso en línea: | https://doi.org/10.35376/10324/63677 https://uvadoc.uva.es/handle/10324/63677 |
| Access Level: | acceso abierto |
| Palabra clave: | Lípidos Lipidomics Lipidómica Metabolomics 2302 Bioquímica |
| Sumario: | This work consists of the description of the lipid profile of different cellular systems, mainly macrophages, in which a key lipid metabolism enzyme, lipin-2, is not present. It has been studied using different techniques, mainly mass spectrometry, how the lack of lipin-2 affects the levels of the different classes of lipids in the cell, as well as the metabolic and functional biological consequences that may be affected, such as membrane fluidity. , cell viability, or phospholipid remodeling. |
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