Tick-pathogen interactions and vector competence: Identification of molecular drivers for tick-borne diseases

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-...

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Detalles Bibliográficos
Autores: Fuente, José de la, Antunes, Sandra, Bonnet, Sarah I., Cabezas-Cruz, Alejandro, Domingos, Ana, Estrada-Peña, Agustín, Johnson, Nicholas, Kocan, Katherine M., Mansfield, Karen L., Nijhof, Ard M., Papa, Anna, Rudenko, Natalie, Villar, Margarita, Alberdi, Pilar, Torina, Alessandra, Ayllón, Nieves, Vancová, Marie, Golovchenko, Maryna, Grubhoffer, Libor, Caracappa, Santo, Fooks, Anthony R., Gortázar, Christian, Rego, Ryan O. M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/152626
Acceso en línea:http://hdl.handle.net/10261/152626
Access Level:acceso abierto
Palabra clave:Anaplasma
Babesia
Borrelia
Flavivirus
Immunology
Microbiome
Vaccine
Tick
Descripción
Sumario:Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.

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