Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response

3D printing has emerged as a transformative technology in several manufacturing processes, being of particular interest in biomedical research for allowing the creation of 3D structures that mimic native tissues. The process of tissue 3D printing entails the construction of functional, 3D tissue str...

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Autores: Fuentes Llanos, Judith, Guix Noguera, Maria, Cenev, Zoran M., Bakenecker, Anna, Ruiz González, Noelia, Beaune, Grégory, Timonen, Jaakko V. I., Sánchez Ordóñez, Samuel, Magdanz, Veronika
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222741
Acceso en línea:https://hdl.handle.net/2445/222741
Access Level:acceso abierto
Palabra clave:Enginyeria de teixits
Impressió 3D
Tissue engineering
Three-dimensional printing
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spelling Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic responseFuentes Llanos, JudithGuix Noguera, MariaCenev, Zoran M.Bakenecker, AnnaRuiz González, NoeliaBeaune, GrégoryTimonen, Jaakko V. I.Sánchez Ordóñez, SamuelMagdanz, VeronikaEnginyeria de teixitsImpressió 3DTissue engineeringThree-dimensional printing3D printing has emerged as a transformative technology in several manufacturing processes, being of particular interest in biomedical research for allowing the creation of 3D structures that mimic native tissues. The process of tissue 3D printing entails the construction of functional, 3D tissue structures. In this article, the integration of ferrofluid consisting of iron oxide nanoparticles into muscle cell-laden bioink is presented to obtain a 3D printed magnetically responsive muscle tissue, i.e., the ferromuscle. Using extrusion-based methods, the seamless integration of biocompatible ferrofluids are achieved to cell-laden hydrogels. The resulting ferromuscle tissue exhibits improved tissue differentiation demonstrated by the increased force output upon electrical stimulation compared to muscle tissue prepared without ferrofluid. Moreover, the magnetic component originating from the iron oxide nanoparticles allows magnetic guidance, as well as good cytocompatibility and biodegradability in cell culture. These findings offer a new versatile fabrication approach to integrate magnetic components into living constructs, with potential applications as bioactuators and for future integration in smart, functional muscle implants.John Wiley & Sons2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222741Articles publicats en revistes (Ciència dels Materials i Química Física)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/admi.202400824Advanced materials interfaces, 2025, vol. 12, num. 13, 2400824https://doi.org/10.1002/admi.202400824cc-by (c) Fuentes Llanos, Judith et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2227412026-05-27T06:46:51Z
dc.title.none.fl_str_mv Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
title Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
spellingShingle Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
Fuentes Llanos, Judith
Enginyeria de teixits
Impressió 3D
Tissue engineering
Three-dimensional printing
title_short Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
title_full Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
title_fullStr Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
title_full_unstemmed Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
title_sort Ferrofluid-based bioink for 3d printed skeletal muscle tissues with enhanced force and magnetic response
dc.creator.none.fl_str_mv Fuentes Llanos, Judith
Guix Noguera, Maria
Cenev, Zoran M.
Bakenecker, Anna
Ruiz González, Noelia
Beaune, Grégory
Timonen, Jaakko V. I.
Sánchez Ordóñez, Samuel
Magdanz, Veronika
author Fuentes Llanos, Judith
author_facet Fuentes Llanos, Judith
Guix Noguera, Maria
Cenev, Zoran M.
Bakenecker, Anna
Ruiz González, Noelia
Beaune, Grégory
Timonen, Jaakko V. I.
Sánchez Ordóñez, Samuel
Magdanz, Veronika
author_role author
author2 Guix Noguera, Maria
Cenev, Zoran M.
Bakenecker, Anna
Ruiz González, Noelia
Beaune, Grégory
Timonen, Jaakko V. I.
Sánchez Ordóñez, Samuel
Magdanz, Veronika
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enginyeria de teixits
Impressió 3D
Tissue engineering
Three-dimensional printing
topic Enginyeria de teixits
Impressió 3D
Tissue engineering
Three-dimensional printing
description 3D printing has emerged as a transformative technology in several manufacturing processes, being of particular interest in biomedical research for allowing the creation of 3D structures that mimic native tissues. The process of tissue 3D printing entails the construction of functional, 3D tissue structures. In this article, the integration of ferrofluid consisting of iron oxide nanoparticles into muscle cell-laden bioink is presented to obtain a 3D printed magnetically responsive muscle tissue, i.e., the ferromuscle. Using extrusion-based methods, the seamless integration of biocompatible ferrofluids are achieved to cell-laden hydrogels. The resulting ferromuscle tissue exhibits improved tissue differentiation demonstrated by the increased force output upon electrical stimulation compared to muscle tissue prepared without ferrofluid. Moreover, the magnetic component originating from the iron oxide nanoparticles allows magnetic guidance, as well as good cytocompatibility and biodegradability in cell culture. These findings offer a new versatile fabrication approach to integrate magnetic components into living constructs, with potential applications as bioactuators and for future integration in smart, functional muscle implants.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222741
url https://hdl.handle.net/2445/222741
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/admi.202400824
Advanced materials interfaces, 2025, vol. 12, num. 13, 2400824
https://doi.org/10.1002/admi.202400824
dc.rights.none.fl_str_mv cc-by (c) Fuentes Llanos, Judith et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Fuentes Llanos, Judith et al., 2025
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Ciència dels Materials i Química Física)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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