Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia

The International Prognostic Score of thrombosis in Essential Thrombocythemia (IPSET-Thrombosis) and its revised version have been proposed to guide thrombosis prevention strategies. We evaluated both classifications to prognosticate thrombosis in 1366 contemporary essential thrombocythemia (ET) pat...

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Autores: Alvarez-Larrán, A., Cuevas, B., Velez, P., Noya Pereira, María Soledad, Caballero-Navarro, G., Ferrer-Marín, F., Carbonell, S., Pérez Encinas, Manuel Mateo, Gómez-Casares, M.T., Pérez-López, R., Magro, E., Moretó, A., Pastor-Galán, I., Angona, A., Mata-Vázquez, M.I., Guerrero-Fernández, L., Guerra, J.M., Carreño-Tarragona, G., Fox, L., Murillo, I., García-Gutiérrez, V., Mora, E., Stuckey, R., Arellano-Rodrigo, E., Hernández-Boluda, J.C., Pereira, A.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21094
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64e2a6824a4f093d56e74951
http://hdl.handle.net/20.500.11940/21094
Access Level:acceso abierto
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CHUAC
AS Santiago
CHUS
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spelling Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential ThrombocythemiaAlvarez-Larrán, A.Cuevas, B.Velez, P.Noya Pereira, María SoledadCaballero-Navarro, G.Ferrer-Marín, F.Carbonell, S.Pérez Encinas, Manuel MateoGómez-Casares, M.T.Pérez-López, R.Magro, E.Moretó, A.Pastor-Galán, I.Angona, A.Mata-Vázquez, M.I.Guerrero-Fernández, L.Guerra, J.M.Carreño-Tarragona, G.Fox, L.Murillo, I.García-Gutiérrez, V.Mora, E.Stuckey, R.Arellano-Rodrigo, E.Hernández-Boluda, J.C.Pereira, A.AS A CoruñaCHUACAS SantiagoCHUSThe International Prognostic Score of thrombosis in Essential Thrombocythemia (IPSET-Thrombosis) and its revised version have been proposed to guide thrombosis prevention strategies. We evaluated both classifications to prognosticate thrombosis in 1366 contemporary essential thrombocythemia (ET) patients prospectively followed from the Spanish Registry of ET. The cumulative incidence of thrombosis at 10 years, taking death as a competing risk, was 11.4%. The risk of thrombosis was significantly higher in the high-risk IPSET-Thrombosis and high-risk revised IPSET-Thrombosis, but no differences were observed among the lower risk categories. Patients allocated in high-risk IPSET-Thrombosis (subdistribution hazard ratios [SHR], 3.7 [95% confidence interval, CI, 1.6-8.7]) and high-risk revised IPSET-Thrombosis (SHR, 3.2 [95% CI, 1.4-7.45]) showed an increased risk of arterial thrombosis, whereas both scoring systems failed to predict venous thrombosis. The incidence rate of thrombosis in intermediate risk revised IPSET-Thrombosis (aged >60 years, JAK2-negative, and no history of thrombosis) was very low regardless of the treatment administered (0.9% and 0% per year with and without cytoreduction, respectively). Dynamic application of the revised IPSET-Thrombosis showed a low rate of thrombosis when patients without history of prior thrombosis switched to a higher risk category after reaching 60 years of age. In conclusion, IPSET-Thrombosis scores are useful for identifying patients at high risk of arterial thrombosis, whereas they fail to predict venous thrombosis. Controlled studies are needed to determine the appropriate treatment of ET patients assigned to the non-high-risk categories.The Spanish registry of Essential thrombocythemia is financed with GEMFIN's own funds without direct collaboration from any pharmaceutical company. This work was supported by PI21/00231, PI21/00347, and PI21/00538 from the Instituto de Salud Carlos III (ISCIII), through the Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion.2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/64e2a6824a4f093d56e74951http://hdl.handle.net/20.500.11940/21094reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/210942026-06-12T08:40:47Z
dc.title.none.fl_str_mv Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
title Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
spellingShingle Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
Alvarez-Larrán, A.
AS A Coruña
CHUAC
AS Santiago
CHUS
title_short Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
title_full Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
title_fullStr Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
title_full_unstemmed Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
title_sort Application of IPSET-Thrombosis in 1366 Patients Prospectively Followed from the Spanish Registry of Essential Thrombocythemia
dc.creator.none.fl_str_mv Alvarez-Larrán, A.
Cuevas, B.
Velez, P.
Noya Pereira, María Soledad
Caballero-Navarro, G.
Ferrer-Marín, F.
Carbonell, S.
Pérez Encinas, Manuel Mateo
Gómez-Casares, M.T.
Pérez-López, R.
Magro, E.
Moretó, A.
Pastor-Galán, I.
Angona, A.
Mata-Vázquez, M.I.
Guerrero-Fernández, L.
Guerra, J.M.
Carreño-Tarragona, G.
Fox, L.
Murillo, I.
García-Gutiérrez, V.
Mora, E.
Stuckey, R.
Arellano-Rodrigo, E.
Hernández-Boluda, J.C.
Pereira, A.
author Alvarez-Larrán, A.
author_facet Alvarez-Larrán, A.
Cuevas, B.
Velez, P.
Noya Pereira, María Soledad
Caballero-Navarro, G.
Ferrer-Marín, F.
Carbonell, S.
Pérez Encinas, Manuel Mateo
Gómez-Casares, M.T.
Pérez-López, R.
Magro, E.
Moretó, A.
Pastor-Galán, I.
Angona, A.
Mata-Vázquez, M.I.
Guerrero-Fernández, L.
Guerra, J.M.
Carreño-Tarragona, G.
Fox, L.
Murillo, I.
García-Gutiérrez, V.
Mora, E.
Stuckey, R.
Arellano-Rodrigo, E.
Hernández-Boluda, J.C.
Pereira, A.
author_role author
author2 Cuevas, B.
Velez, P.
Noya Pereira, María Soledad
Caballero-Navarro, G.
Ferrer-Marín, F.
Carbonell, S.
Pérez Encinas, Manuel Mateo
Gómez-Casares, M.T.
Pérez-López, R.
Magro, E.
Moretó, A.
Pastor-Galán, I.
Angona, A.
Mata-Vázquez, M.I.
Guerrero-Fernández, L.
Guerra, J.M.
Carreño-Tarragona, G.
Fox, L.
Murillo, I.
García-Gutiérrez, V.
Mora, E.
Stuckey, R.
Arellano-Rodrigo, E.
Hernández-Boluda, J.C.
Pereira, A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AS A Coruña
CHUAC
AS Santiago
CHUS
topic AS A Coruña
CHUAC
AS Santiago
CHUS
description The International Prognostic Score of thrombosis in Essential Thrombocythemia (IPSET-Thrombosis) and its revised version have been proposed to guide thrombosis prevention strategies. We evaluated both classifications to prognosticate thrombosis in 1366 contemporary essential thrombocythemia (ET) patients prospectively followed from the Spanish Registry of ET. The cumulative incidence of thrombosis at 10 years, taking death as a competing risk, was 11.4%. The risk of thrombosis was significantly higher in the high-risk IPSET-Thrombosis and high-risk revised IPSET-Thrombosis, but no differences were observed among the lower risk categories. Patients allocated in high-risk IPSET-Thrombosis (subdistribution hazard ratios [SHR], 3.7 [95% confidence interval, CI, 1.6-8.7]) and high-risk revised IPSET-Thrombosis (SHR, 3.2 [95% CI, 1.4-7.45]) showed an increased risk of arterial thrombosis, whereas both scoring systems failed to predict venous thrombosis. The incidence rate of thrombosis in intermediate risk revised IPSET-Thrombosis (aged >60 years, JAK2-negative, and no history of thrombosis) was very low regardless of the treatment administered (0.9% and 0% per year with and without cytoreduction, respectively). Dynamic application of the revised IPSET-Thrombosis showed a low rate of thrombosis when patients without history of prior thrombosis switched to a higher risk category after reaching 60 years of age. In conclusion, IPSET-Thrombosis scores are useful for identifying patients at high risk of arterial thrombosis, whereas they fail to predict venous thrombosis. Controlled studies are needed to determine the appropriate treatment of ET patients assigned to the non-high-risk categories.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/64e2a6824a4f093d56e74951
http://hdl.handle.net/20.500.11940/21094
url https://portalcientifico.sergas.gal//documentos/64e2a6824a4f093d56e74951
http://hdl.handle.net/20.500.11940/21094
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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