Regulation of natural killer and cd4+T cell function by NKG2 C-type lectin-like receptors
This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell receptors, and demonstrate that the C-type lectin-like receptor NKG2D is expresse...
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| Tipo de documento: | tese |
| Estado: | Versão publicada |
| Data de publicação: | 2009 |
| País: | España |
| Recursos: | CBUC, CESCA |
| Repositório: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/7133 |
| Acesso em linha: | http://www.tdx.cat/TDX-0612109-142651 http://hdl.handle.net/10803/7133 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Human Cytomegalovirus CD94/NKG2 KIR ILT2 NKG2D C-type lectin-like receptors Natural Killer cell Receptors CD4+T cells Natural Killer cells 576 |
| Resumo: | This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell receptors, and demonstrate that the C-type lectin-like receptor NKG2D is expressed on cytotoxic CD4+T cells with an effector/memory phenotype, enhancing their TCR-dependent proliferation and cytokine production. A second part of the work is centered on the study of the CD94/NKG2 receptors on NK cells. We show that NKG2A can be induced on NKG2C+ NK cells upon activation with rIL-12 or when cocultured with HCMV-infected dendritic cells, and that NKG2A expression inhibits the response of NKG2C+NK clones against HLA-E-expressing targets, providing a potential regulatory feedback mechanism to control cell activation. Altogether, our results support that expression of NKG2 C-type lectin like receptors may be shaped during the course of viral infections, providing mechanisms to finely regulate both NK and CD4+T cell functions. |
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