Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity

The relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicil...

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Autores: Ballester, Ana Rosa, Marcet Houben, Marina, Levin, Elena, Sela, Noa, Selma Lázaro, Cristina, Carmona, Lourdes, Wisniewski, Michael, Droby, Samir, González Candelas, Luis, Gabaldón Estevan, Juan Antonio, 1973-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/25102
Acceso en línea:http://hdl.handle.net/10230/25102
http://dx.doi.org/10.1094/MPMI-09-14-0261-FI
Access Level:acceso abierto
Palabra clave:Fongs patògens
Fongs -- Genètica
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spelling Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicityBallester, Ana RosaMarcet Houben, MarinaLevin, ElenaSela, NoaSelma Lázaro, CristinaCarmona, LourdesWisniewski, MichaelDroby, SamirGonzález Candelas, LuisGabaldón Estevan, Juan Antonio, 1973-Fongs patògensFongs -- GenèticaThe relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicillium expansum strains, the main postharvest pathogen of pome fruit, and one Pencillium italicum strain, a postharvest pathogen of citrus fruit, were sequenced and compared with 24 other fungal species. A genomic analysis of gene clusters responsible for the production of secondary metabolites was performed. Putative virulence factors in P. expansum were identified by means of a transcriptomic analysis of apple fruits during the course of infection. Despite a major genome contraction, P. expansum is the Penicillium species with the largest potential for the production of secondary metabolites. Results using knockout mutants clearly demonstrated that neither patulin nor citrinin are required by P. expansum to successfully infect apples. Li et al. ( MPMI-12-14-0398-FI ) reported similar results and conclusions in their recently accepted paper.Work at L. González-Candelas’ lab was partially supported by the Spanish Ministry of Economy and Innovation (Research Grants AGL-2008-04828-C03-02 and AGL2011-30519-C03-01) and by the Generalitat Valenciana, Spain(PROMETEO/2010/010 and PROMETEOII/2014/027). A.-R. Ballester is grateful to CSIC and the European Social Fund for her postdoctoral contract JAE-Doc. C. Selma-Lázaro is recipient of a FPI Predoctoral fellowship from the Spanish MICINN (BES-2012-054595). The T. Gabaldón group research is funded, in part, by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC (Grant Agreement n. ERC-2012- StG-310325).APS Press201520152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25102http://dx.doi.org/10.1094/MPMI-09-14-0261-FIreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMolecular plant-microbe interactions: MPMI. 2015;28(3):232-48info:eu-repo/grantAgreement/EC/FP7/310325info:eu-repo/grantAgreement/ES/3PN/AGL2008-04828info:eu-repo/grantAgreement/ES/3PN/AGL2011-30519info:eu-repo/grantAgreement/ES/3PN/BES2012-054595info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161© The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/251022026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
title Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
spellingShingle Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
Ballester, Ana Rosa
Fongs patògens
Fongs -- Genètica
title_short Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
title_full Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
title_fullStr Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
title_full_unstemmed Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
title_sort Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
dc.creator.none.fl_str_mv Ballester, Ana Rosa
Marcet Houben, Marina
Levin, Elena
Sela, Noa
Selma Lázaro, Cristina
Carmona, Lourdes
Wisniewski, Michael
Droby, Samir
González Candelas, Luis
Gabaldón Estevan, Juan Antonio, 1973-
author Ballester, Ana Rosa
author_facet Ballester, Ana Rosa
Marcet Houben, Marina
Levin, Elena
Sela, Noa
Selma Lázaro, Cristina
Carmona, Lourdes
Wisniewski, Michael
Droby, Samir
González Candelas, Luis
Gabaldón Estevan, Juan Antonio, 1973-
author_role author
author2 Marcet Houben, Marina
Levin, Elena
Sela, Noa
Selma Lázaro, Cristina
Carmona, Lourdes
Wisniewski, Michael
Droby, Samir
González Candelas, Luis
Gabaldón Estevan, Juan Antonio, 1973-
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fongs patògens
Fongs -- Genètica
topic Fongs patògens
Fongs -- Genètica
description The relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicillium expansum strains, the main postharvest pathogen of pome fruit, and one Pencillium italicum strain, a postharvest pathogen of citrus fruit, were sequenced and compared with 24 other fungal species. A genomic analysis of gene clusters responsible for the production of secondary metabolites was performed. Putative virulence factors in P. expansum were identified by means of a transcriptomic analysis of apple fruits during the course of infection. Despite a major genome contraction, P. expansum is the Penicillium species with the largest potential for the production of secondary metabolites. Results using knockout mutants clearly demonstrated that neither patulin nor citrinin are required by P. expansum to successfully infect apples. Li et al. ( MPMI-12-14-0398-FI ) reported similar results and conclusions in their recently accepted paper.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25102
http://dx.doi.org/10.1094/MPMI-09-14-0261-FI
url http://hdl.handle.net/10230/25102
http://dx.doi.org/10.1094/MPMI-09-14-0261-FI
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular plant-microbe interactions: MPMI. 2015;28(3):232-48
info:eu-repo/grantAgreement/EC/FP7/310325
info:eu-repo/grantAgreement/ES/3PN/AGL2008-04828
info:eu-repo/grantAgreement/ES/3PN/AGL2011-30519
info:eu-repo/grantAgreement/ES/3PN/BES2012-054595
info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv APS Press
publisher.none.fl_str_mv APS Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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