Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells

Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provide an effective ancillary therapy to improve cardiac function in reperfused myocardial infarction. We set out to perform a comprehensive preclinical feasibility and safety evaluation of porcine CPC (pCPC) in the i...

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Detalles Bibliográficos
Autores: Crisostomo, Veronica, Baez, Claudia, Abad, José Luis, Sánchez, Belén, Álvarez, Virginia, Rosado, Rosalba, Gómez Mauricio, Guadalupe, Gheysens, Olivier, Blanco Blazquez, Virginia, Blázquez, Rebeca, Torán, José Luis, Casado, Javier G., Aguilar, Susana, Janssens, Stefan, Sánchez-Margallo, Francisco M., Rodríguez Borlado, Luis, Bernad, Antonio, Palacios, Itziar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/211108
Acceso en línea:http://hdl.handle.net/10261/211108
Access Level:acceso abierto
Palabra clave:Cardiac progenitor/stem cells
CPC
Acute myocardial infarction
Swine model
Allogeneic
Intracoronary administration
Descripción
Sumario:Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provide an effective ancillary therapy to improve cardiac function in reperfused myocardial infarction. We set out to perform a comprehensive preclinical feasibility and safety evaluation of porcine CPC (pCPC) in the infarcted porcine model, analyzing biodistribution and mid-term efficacy, as well as safety in healthy non-infarcted swine.

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