Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease
Biomarcador; Expressió gènica; Malaltia inflamatòria intestinal
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/5958 |
| Acceso en línea: | https://hdl.handle.net/11351/5958 http://hdl.handle.net/11351/5958 |
| Access Level: | acceso abierto |
| Palabra clave: | Intestins - Inflamació Medicaments - Administració Adolescents DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy NAMED GROUPS::Persons::Age Groups::Adolescent ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente |
| id |
ES_61a2da777591ecf5dae566580d4f41d7 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:11351/5958 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| title |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| spellingShingle |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease Kaczmarczyk, Bartosz Intestins - Inflamació Medicaments - Administració Adolescents DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy NAMED GROUPS::Persons::Age Groups::Adolescent ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente |
| title_short |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| title_full |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| title_fullStr |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| title_full_unstemmed |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| title_sort |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease |
| dc.creator.none.fl_str_mv |
Kaczmarczyk, Bartosz Álvarez, Rebeca Navas-López, Víctor Manuel Gallego-Fernández, Carmen Moreno-Álvarez, Ana Clemente Bautista, Susana Salvador-Martín, Sara |
| author |
Kaczmarczyk, Bartosz |
| author_facet |
Kaczmarczyk, Bartosz Álvarez, Rebeca Navas-López, Víctor Manuel Gallego-Fernández, Carmen Moreno-Álvarez, Ana Clemente Bautista, Susana Salvador-Martín, Sara |
| author_role |
author |
| author2 |
Álvarez, Rebeca Navas-López, Víctor Manuel Gallego-Fernández, Carmen Moreno-Álvarez, Ana Clemente Bautista, Susana Salvador-Martín, Sara |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Salvador-Martín S, Kaczmarczyk B] Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain. [Álvarez R] Genomics Unit, Spanish Nacional Center for Cardiovascular Diseases (CNIC), 28029 Madrid, Spain. [Navas-López VM] Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, IBIMA Multidisciplinary Group for Pediatric Research, 29010 Málaga, Spain. [Gallego-Fernández C] Pharmacy Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain. [Moreno-Álvarez A] Pediatric Gastroenterology Unit, Department of Pediatrics, A Coruña University Hospital, 15006 A Coruña, Spain. [Clemente S] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Intestins - Inflamació Medicaments - Administració Adolescents DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy NAMED GROUPS::Persons::Age Groups::Adolescent ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente |
| topic |
Intestins - Inflamació Medicaments - Administració Adolescents DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases Other subheadings::Other subheadings::Other subheadings::/drug therapy NAMED GROUPS::Persons::Age Groups::Adolescent ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente |
| description |
Biomarcador; Expressió gènica; Malaltia inflamatòria intestinal |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/5958 http://hdl.handle.net/11351/5958 |
| url |
https://hdl.handle.net/11351/5958 http://hdl.handle.net/11351/5958 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Pharmaceutics;13(1) https://doi.org/10.3390/pharmaceutics13010077 info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00559 info:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F00792 info:eu-repo/grantAgreement/ES/PE2013-2016/PEJ16%2FMED%2FAI-1260 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869409431944429568 |
| spelling |
Whole Transcription Profile of Responders to Anti-TNF Drugs in Pediatric Inflammatory Bowel DiseaseKaczmarczyk, BartoszÁlvarez, RebecaNavas-López, Víctor ManuelGallego-Fernández, CarmenMoreno-Álvarez, AnaClemente Bautista, SusanaSalvador-Martín, SaraIntestins - InflamacióMedicaments - AdministracióAdolescentsDISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel DiseasesOther subheadings::Other subheadings::Other subheadings::/drug therapyNAMED GROUPS::Persons::Age Groups::AdolescentENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinalOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaDENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescenteBiomarcador; Expressió gènica; Malaltia inflamatòria intestinalBiomarcador; Expresión génica; Enfermedad inflamatoria intestinalBiomarker; Gene expression; Inflammatory bowel diseaseBackground: Up to 30% of patients with pediatric inflammatory bowel disease (IBD) do not respond to anti-Tumor Necrosis Factor (anti-TNF) therapy. The aim of this study was to identify pharmacogenomic markers that predict early response to anti-TNF drugs in pediatric patients with IBD. Methods: An observational, longitudinal, prospective cohort study was conducted. The study population comprised 38 patients with IBD aged < 18 years who started treatment with infliximab or adalimumab (29 responders and nine non-responders). Whole gene expression profiles from total RNA isolated from whole blood samples of six responders and six non-responders taken before administration of the biologic and after two weeks of therapy were analyzed using next-generation RNA sequencing. The expression of six selected genes was measured for purposes of validation in all of the 38 patients recruited using qPCR. Results: Genes were differentially expressed in non-responders and responders (32 before initiation of treatment and 44 after two weeks, Log2FC (Fold change) >0.6 or <−0.6 and p value < 0.05). After validation, FCGR1A, FCGR1B, and GBP1 were overexpressed in non-responders two weeks after initiation of anti-TNF treatment (Log2FC 1.05, 1.21, and 1.08, respectively, p value < 0.05). Conclusion: Expression of the FCGR1A, FCGR1B, and GBP1 genes is a pharmacogenomic biomarker of early response to anti-TNF agents in pediatric IBD.This research was funded by Instituto de Salud Carlos III (grants numbers PI16/00559 and PI19/00792), Consejería de Educación y Deporte de la Comunidad de Madrid (grant number PEJ16/MED/AI-1260), and by the Gregorio Marañón Health Research Institute (grant number PRE-2018-2). The study was cofunded by European Regional Develompment Funds (FEDER) from the European Commission, “A way of making Europe”.MDPIInstitut Català de la Salut[Salvador-Martín S, Kaczmarczyk B] Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain. [Álvarez R] Genomics Unit, Spanish Nacional Center for Cardiovascular Diseases (CNIC), 28029 Madrid, Spain. [Navas-López VM] Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, IBIMA Multidisciplinary Group for Pediatric Research, 29010 Málaga, Spain. [Gallego-Fernández C] Pharmacy Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain. [Moreno-Álvarez A] Pediatric Gastroenterology Unit, Department of Pediatrics, A Coruña University Hospital, 15006 A Coruña, Spain. [Clemente S] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/5958http://hdl.handle.net/11351/5958Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPharmaceutics;13(1)https://doi.org/10.3390/pharmaceutics13010077info:eu-repo/grantAgreement/ES/PE2013-2016/PI16%2F00559info:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F00792info:eu-repo/grantAgreement/ES/PE2013-2016/PEJ16%2FMED%2FAI-1260Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/59582026-05-29T05:05:01Z |
| score |
15,812429 |