Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological p...

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Autores: Gómez-Acebo, Inés, Domingo, Laia, Castaño Vinyals, Gemma, Kogevinas, Manolis, Llorca, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/44642
Acceso en línea:http://hdl.handle.net/10230/44642
http://dx.doi.org/10.1007/s10549-020-05600-x
Access Level:acceso abierto
Palabra clave:Breast cancer
Cohort
Epidemiology
MCC-Spain
Relative survival
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spelling Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain studyGómez-Acebo, InésDomingo, LaiaCastaño Vinyals, GemmaKogevinas, ManolisLlorca, JavierBreast cancerCohortEpidemiologyMCC-SpainRelative survivalPurpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.SpringerOpen202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44642http://dx.doi.org/10.1007/s10549-020-05600-xreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBreast Cancer Research and Treatment. 2020 Jun;181(3):667-8© The Author(s) 2020 .Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/446422026-05-29T05:05:01Z
dc.title.none.fl_str_mv Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
spellingShingle Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
Gómez-Acebo, Inés
Breast cancer
Cohort
Epidemiology
MCC-Spain
Relative survival
title_short Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_fullStr Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full_unstemmed Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_sort Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
dc.creator.none.fl_str_mv Gómez-Acebo, Inés
Domingo, Laia
Castaño Vinyals, Gemma
Kogevinas, Manolis
Llorca, Javier
author Gómez-Acebo, Inés
author_facet Gómez-Acebo, Inés
Domingo, Laia
Castaño Vinyals, Gemma
Kogevinas, Manolis
Llorca, Javier
author_role author
author2 Domingo, Laia
Castaño Vinyals, Gemma
Kogevinas, Manolis
Llorca, Javier
author2_role author
author
author
author
dc.subject.none.fl_str_mv Breast cancer
Cohort
Epidemiology
MCC-Spain
Relative survival
topic Breast cancer
Cohort
Epidemiology
MCC-Spain
Relative survival
description Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/44642
http://dx.doi.org/10.1007/s10549-020-05600-x
url http://hdl.handle.net/10230/44642
http://dx.doi.org/10.1007/s10549-020-05600-x
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Breast Cancer Research and Treatment. 2020 Jun;181(3):667-8
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SpringerOpen
publisher.none.fl_str_mv SpringerOpen
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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