Genetic patterns related to von Willebrand factor: implications on the need for mechanical ventilation, severity, and death in COVID-19
Background: Elevated levels of Von Willebrand Factor (VWF) have been associated to an increased need of mechanical ventilation and higher mortality risk in COVID-19 patients, but the hypothesis of a shared genetic background has not been explored. Methods: Common and low-frequency genetic variants b...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:ucreareposit::3e10466661ea526d023c566075cfabcf |
| Acceso en línea: | https://hdl.handle.net/10902/40318 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 severity Von Willebrand factor Admixed population Invasive mechanical ventilation VWF gene |
| Sumario: | Background: Elevated levels of Von Willebrand Factor (VWF) have been associated to an increased need of mechanical ventilation and higher mortality risk in COVID-19 patients, but the hypothesis of a shared genetic background has not been explored. Methods: Common and low-frequency genetic variants belonging to the VWF, FVIII, and ADAMTS13 genes were tested for association with clinical variables related to severe COVID-19 disease in 9,371 European and 3,495 Latin-American patients. Gene-environment and gene-gene interactions were also explored. Results: A variant in the VWF gene was associated to the need of invasive mechanical ventilation (IMV) in the Latin-American population. Gene-gene interaction models pointed to an interaction between ADAMTS13 and VWF genes. Conclusion: Although we did not find significant associations among Europeans, we identified a low-frequency variant belonging to the VWF gene associated with the need of IMV in Latin-Americans. |
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