Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss

Background: Bariatric surgery effectively treats severe obesity, but postoperative weight loss includes reductions in both fat mass (FM) and fat-free mass (FFM). Excessive FFM loss may increase the risk of sarcopenia, frailty, and long-term weight regain, yet its magnitude and determinants are not f...

Descripción completa

Detalles Bibliográficos
Autores: Perez-Romero, N, Trapé, MA, Caixàs, A, Secilla, AC, Vicente, CJH, Moral, ML, Hernandez-Lazaro, A, Aufroy, AL
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6920
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6920
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105028652071&doi=10.3390%2Fjcm15020630&partnerID=40&md5=eefd9bd0688475f7bf4e7fb71a876076
Access Level:acceso abierto
Palabra clave:bariatric surgery
body composition
fat-free mass loss
sarcopenic obesity
weight loss outcomes
bioelectrical impedance analysis
postoperative monitoring
id ES_60fb3fd09f06bacdf82aef118d960ce3
oai_identifier_str oai:i3pt.fundanetsuite.com:p6920
network_acronym_str ES
network_name_str España
repository_id_str
spelling Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass LossPerez-Romero, NTrapé, MACaixàs, ASecilla, ACVicente, CJHMoral, MLHernandez-Lazaro, AAufroy, ALbariatric surgerybody compositionfat-free mass losssarcopenic obesityweight loss outcomesbioelectrical impedance analysispostoperative monitoringBackground: Bariatric surgery effectively treats severe obesity, but postoperative weight loss includes reductions in both fat mass (FM) and fat-free mass (FFM). Excessive FFM loss may increase the risk of sarcopenia, frailty, and long-term weight regain, yet its magnitude and determinants are not fully established. Methods: We conducted a retrospective analysis of a prospectively collected cohort of 179 patients who underwent laparoscopic or robotic Roux-en-Y gastric bypass between January 2020 and December 2022. Anthropometric parameters and body composition (bioelectrical impedance analysis) were measured preoperatively and at 6 and 12 months. The proportion of FFM loss relative to total weight loss (%FFML/WL) was calculated, and excessive FFM loss was defined using published cut-offs (>= 25%, >= 30%, and >= 35%). Predictors of FFM preservation were assessed through stepwise regression. Results: Baseline BMI was 44.1 +/- 4.6 kg/m(2), FM 54.6 +/- 10.7 kg, and FFM 61.1 +/- 11.9 kg. At 6 and 12 months, BMI decreased to 31.0 +/- 4.2 and 28.8 +/- 4.4 kg/m(2), respectively; FM decreased to 35.6 +/- 11.0 and 22.0 +/- 10.0 kg; and FFM to 54.7 +/- 9.5 and 50.1 +/- 7.0 kg (all p < 0.001). Most FFM loss occurred within the first 6 months (mean - 6.4 kg). Median %FFML/WL was 26.4% at 6 months and 28.7% at 12 months. Excessive FFM loss affected 41-46% of patients (>= 25%), 27-31% (>= 30%), and 14% (>= 35%). In multivariable analysis, FFM at 6 months was the only independent predictor of FFM at 12 months (p < 0.001). Conclusions: Bariatric surgery leads to substantial FM and FFM reductions, with nearly half of patients exceeding established %FFML/WL alert thresholds. Early postoperative body composition monitoring may help identify individuals at higher risk of FFM depletion and guide preventive strategies such as adequate protein intake and resistance training.MDPI2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6920https://www.scopus.com/inward/record.uri?eid=2-s2.0-105028652071&doi=10.3390%2Fjcm15020630&partnerID=40&md5=eefd9bd0688475f7bf4e7fb71a876076Journal of Clinical MedicineISSN: 20770383reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p69202026-06-21T15:30:37Z
dc.title.none.fl_str_mv Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
title Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
spellingShingle Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
Perez-Romero, N
bariatric surgery
body composition
fat-free mass loss
sarcopenic obesity
weight loss outcomes
bioelectrical impedance analysis
postoperative monitoring
title_short Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
title_full Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
title_fullStr Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
title_full_unstemmed Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
title_sort Body Composition Changes After Bariatric Surgery: Magnitude, Timing, and Determinants of Excessive Fat-Free Mass Loss
dc.creator.none.fl_str_mv Perez-Romero, N
Trapé, MA
Caixàs, A
Secilla, AC
Vicente, CJH
Moral, ML
Hernandez-Lazaro, A
Aufroy, AL
author Perez-Romero, N
author_facet Perez-Romero, N
Trapé, MA
Caixàs, A
Secilla, AC
Vicente, CJH
Moral, ML
Hernandez-Lazaro, A
Aufroy, AL
author_role author
author2 Trapé, MA
Caixàs, A
Secilla, AC
Vicente, CJH
Moral, ML
Hernandez-Lazaro, A
Aufroy, AL
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bariatric surgery
body composition
fat-free mass loss
sarcopenic obesity
weight loss outcomes
bioelectrical impedance analysis
postoperative monitoring
topic bariatric surgery
body composition
fat-free mass loss
sarcopenic obesity
weight loss outcomes
bioelectrical impedance analysis
postoperative monitoring
description Background: Bariatric surgery effectively treats severe obesity, but postoperative weight loss includes reductions in both fat mass (FM) and fat-free mass (FFM). Excessive FFM loss may increase the risk of sarcopenia, frailty, and long-term weight regain, yet its magnitude and determinants are not fully established. Methods: We conducted a retrospective analysis of a prospectively collected cohort of 179 patients who underwent laparoscopic or robotic Roux-en-Y gastric bypass between January 2020 and December 2022. Anthropometric parameters and body composition (bioelectrical impedance analysis) were measured preoperatively and at 6 and 12 months. The proportion of FFM loss relative to total weight loss (%FFML/WL) was calculated, and excessive FFM loss was defined using published cut-offs (>= 25%, >= 30%, and >= 35%). Predictors of FFM preservation were assessed through stepwise regression. Results: Baseline BMI was 44.1 +/- 4.6 kg/m(2), FM 54.6 +/- 10.7 kg, and FFM 61.1 +/- 11.9 kg. At 6 and 12 months, BMI decreased to 31.0 +/- 4.2 and 28.8 +/- 4.4 kg/m(2), respectively; FM decreased to 35.6 +/- 11.0 and 22.0 +/- 10.0 kg; and FFM to 54.7 +/- 9.5 and 50.1 +/- 7.0 kg (all p < 0.001). Most FFM loss occurred within the first 6 months (mean - 6.4 kg). Median %FFML/WL was 26.4% at 6 months and 28.7% at 12 months. Excessive FFM loss affected 41-46% of patients (>= 25%), 27-31% (>= 30%), and 14% (>= 35%). In multivariable analysis, FFM at 6 months was the only independent predictor of FFM at 12 months (p < 0.001). Conclusions: Bariatric surgery leads to substantial FM and FFM reductions, with nearly half of patients exceeding established %FFML/WL alert thresholds. Early postoperative body composition monitoring may help identify individuals at higher risk of FFM depletion and guide preventive strategies such as adequate protein intake and resistance training.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6920
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105028652071&doi=10.3390%2Fjcm15020630&partnerID=40&md5=eefd9bd0688475f7bf4e7fb71a876076
url https://i3pt.portalinvestigacion.com/publicaciones/6920
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105028652071&doi=10.3390%2Fjcm15020630&partnerID=40&md5=eefd9bd0688475f7bf4e7fb71a876076
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409359237218304
score 15,812429

Similares en LA Referencia