Genetic Structure of the Spanish Population

Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the p...

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Detalhes bibliográficos
Autores: Gayán, Javier, Galan, José J., González-Pérez, Antonio, Sáez, María Eugenia, Martínez-Larrad, María Teresa, Zabena, Carina, Ramírez Lorca, Reposo, Real Navarrete, Luis Miguel, Serrano-Ríos, Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/176814
Acesso em linha:https://hdl.handle.net/11441/176814
https://doi.org/10.1186/1471-2164-11-326
Access Level:acceso abierto
Palavra-chave:Copy-Number Variations
Human Genome
European Populations
Haplotype Map
Association
Prevalence
Disease
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Genetic Structure of the Spanish PopulationGayán, JavierGalan, José J.González-Pérez, AntonioSáez, María EugeniaMartínez-Larrad, María TeresaZabena, CarinaRamírez Lorca, ReposoReal Navarrete, Luis MiguelSerrano-Ríos, ManuelCopy-Number VariationsHuman GenomeEuropean PopulationsHaplotype MapAssociationPrevalenceDiseaseBackground Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.BioMed CentralFisiología Médica y BiofísicaJunta de AndalucíaCorporación Tecnológica de AndalucíaMinisterio de Educación y Ciencia (MEC). EspañaMinisterio de Ciencia e InnovaciónCIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/176814https://doi.org/10.1186/1471-2164-11-326reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBmc Genomics, 11 (1), 326.830882PCT-A41502790-2007 and PCT-010000-2007-18PTQ2002-0206, PTQ2003-0549, PTQ2003-0546, PTQ2003-0782, PTQ2003-0783, PTQ2004-0838, PTQ04-1-0006, PTQ04-3-0718, PTQ06-1-0002https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-326#Ack1info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1768142026-06-17T12:51:07Z
dc.title.none.fl_str_mv Genetic Structure of the Spanish Population
title Genetic Structure of the Spanish Population
spellingShingle Genetic Structure of the Spanish Population
Gayán, Javier
Copy-Number Variations
Human Genome
European Populations
Haplotype Map
Association
Prevalence
Disease
title_short Genetic Structure of the Spanish Population
title_full Genetic Structure of the Spanish Population
title_fullStr Genetic Structure of the Spanish Population
title_full_unstemmed Genetic Structure of the Spanish Population
title_sort Genetic Structure of the Spanish Population
dc.creator.none.fl_str_mv Gayán, Javier
Galan, José J.
González-Pérez, Antonio
Sáez, María Eugenia
Martínez-Larrad, María Teresa
Zabena, Carina
Ramírez Lorca, Reposo
Real Navarrete, Luis Miguel
Serrano-Ríos, Manuel
author Gayán, Javier
author_facet Gayán, Javier
Galan, José J.
González-Pérez, Antonio
Sáez, María Eugenia
Martínez-Larrad, María Teresa
Zabena, Carina
Ramírez Lorca, Reposo
Real Navarrete, Luis Miguel
Serrano-Ríos, Manuel
author_role author
author2 Galan, José J.
González-Pérez, Antonio
Sáez, María Eugenia
Martínez-Larrad, María Teresa
Zabena, Carina
Ramírez Lorca, Reposo
Real Navarrete, Luis Miguel
Serrano-Ríos, Manuel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
Junta de Andalucía
Corporación Tecnológica de Andalucía
Ministerio de Educación y Ciencia (MEC). España
Ministerio de Ciencia e Innovación
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)
dc.subject.none.fl_str_mv Copy-Number Variations
Human Genome
European Populations
Haplotype Map
Association
Prevalence
Disease
topic Copy-Number Variations
Human Genome
European Populations
Haplotype Map
Association
Prevalence
Disease
description Background Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/176814
https://doi.org/10.1186/1471-2164-11-326
url https://hdl.handle.net/11441/176814
https://doi.org/10.1186/1471-2164-11-326
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bmc Genomics, 11 (1), 326.
830882
PCT-A41502790-2007 and PCT-010000-2007-18
PTQ2002-0206, PTQ2003-0549, PTQ2003-0546, PTQ2003-0782, PTQ2003-0783, PTQ2004-0838, PTQ04-1-0006, PTQ04-3-0718, PTQ06-1-0002
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-326#Ack1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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