Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grad...

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Autores: Schneeberger, Marc, Everard, A., Gómez Valadés, Alicia G., Matamoros, S., Ramírez, Sara, Delzenne, NM., Gomis, Ramon, 1946-, Claret i Carles, Marc, Cani, P. D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/100481
Acceso en línea:https://hdl.handle.net/2445/100481
Access Level:acceso abierto
Palabra clave:Intestins
Microbiologia
Teixit adipós
Obesitat
Ratolins (Animals de laboratori)
Intestines
Microbiology
Adipose tissues
Obesity
Mice (Laboratory animals)
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spelling Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in miceSchneeberger, MarcEverard, A.Gómez Valadés, Alicia G.Matamoros, S.Ramírez, SaraDelzenne, NM.Gomis, Ramon, 1946-Claret i Carles, MarcCani, P. D.IntestinsMicrobiologiaTeixit adipósObesitatRatolins (Animals de laboratori)IntestinesMicrobiologyAdipose tissuesObesityMice (Laboratory animals)Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was the only taxa following an opposite trend. Different approaches, including multifactorial analysis, showed that these changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice. Thus, our data shows the existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity, thus reinforcing the beneficial role of this bacterium on metabolism.Nature Publishing Group2016201620152016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/100481Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1038/srep16643Scientific Reports, 2015, vol. 13, num. 5http://dx.doi.org/10.1038/srep16643info:eu-repo/grantAgreement/EC/FP7/267248info:eu-repo/grantAgreement/EC/FP7/336452cc-by-nc-nd (c) Schneeberger, M. et al., 2015http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1004812026-05-29T05:05:01Z
dc.title.none.fl_str_mv Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
title Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
spellingShingle Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
Schneeberger, Marc
Intestins
Microbiologia
Teixit adipós
Obesitat
Ratolins (Animals de laboratori)
Intestines
Microbiology
Adipose tissues
Obesity
Mice (Laboratory animals)
title_short Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
title_full Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
title_fullStr Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
title_full_unstemmed Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
title_sort Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
dc.creator.none.fl_str_mv Schneeberger, Marc
Everard, A.
Gómez Valadés, Alicia G.
Matamoros, S.
Ramírez, Sara
Delzenne, NM.
Gomis, Ramon, 1946-
Claret i Carles, Marc
Cani, P. D.
author Schneeberger, Marc
author_facet Schneeberger, Marc
Everard, A.
Gómez Valadés, Alicia G.
Matamoros, S.
Ramírez, Sara
Delzenne, NM.
Gomis, Ramon, 1946-
Claret i Carles, Marc
Cani, P. D.
author_role author
author2 Everard, A.
Gómez Valadés, Alicia G.
Matamoros, S.
Ramírez, Sara
Delzenne, NM.
Gomis, Ramon, 1946-
Claret i Carles, Marc
Cani, P. D.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Intestins
Microbiologia
Teixit adipós
Obesitat
Ratolins (Animals de laboratori)
Intestines
Microbiology
Adipose tissues
Obesity
Mice (Laboratory animals)
topic Intestins
Microbiologia
Teixit adipós
Obesitat
Ratolins (Animals de laboratori)
Intestines
Microbiology
Adipose tissues
Obesity
Mice (Laboratory animals)
description Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was the only taxa following an opposite trend. Different approaches, including multifactorial analysis, showed that these changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice. Thus, our data shows the existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity, thus reinforcing the beneficial role of this bacterium on metabolism.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/100481
url https://hdl.handle.net/2445/100481
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1038/srep16643
Scientific Reports, 2015, vol. 13, num. 5
http://dx.doi.org/10.1038/srep16643
info:eu-repo/grantAgreement/EC/FP7/267248
info:eu-repo/grantAgreement/EC/FP7/336452
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Schneeberger, M. et al., 2015
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Schneeberger, M. et al., 2015
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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