Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children

The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed...

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Autores: Ezpeleta, Lourdes|||0000-0002-8957-083X, Penelo Werner, Eva|||0000-0001-6796-7660, Osa, Nuria de la|||0000-0003-4499-0942, Navarro, José-Blas|||0000-0001-5929-4224, Fañanás Saura, Lourdes, Fatjó-Vilas, Mar|||0000-0001-9963-6241
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:204224
Acceso en línea:https://ddd.uab.cat/record/204224
https://dx.doi.org/urn:doi:10.1007/s10802-019-00548-z
Access Level:acceso abierto
Palabra clave:Callous-unemotional
Developmental trajectories
Life events
OXTR
Rs53576
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spelling Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community childrenEzpeleta, Lourdes|||0000-0002-8957-083XPenelo Werner, Eva|||0000-0001-6796-7660Osa, Nuria de la|||0000-0003-4499-0942Navarro, José-Blas|||0000-0001-5929-4224Fañanás Saura, LourdesFatjó-Vilas, Mar|||0000-0001-9963-6241Callous-unemotionalDevelopmental trajectoriesLife eventsOXTRRs53576The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed yearly from ages 3 to 9 years. Latent class growth analysis for parallel processes was used to identify distinct trajectories for callous-unemotional traits (assessed using the Inventory of Callous-Unemotional Traits, ICU) and number of stressful life-events, and then the influence of being an A allele carrier on class membership was included with OXTR genotypes as a binary time-invariant predictor, following a 3-step approach. A 3-class model showed the highest entropy (.859) and adequate posterior probabilities of class membership (≥.884). Class 1 (n = 226, 59.9%) included children with low and stable ICU scores and low and descending stressful life-events; class 2 (n = 127, 33.7%) included children with high and ascending ICU scores and low and slightly descending stressful life-events; and class 3 (n = 24, 6.4%) included children with persistently high profiles both for ICU scores and stressful life-events. Carrying an A allele (genotypes GA/AA) increased the odds of pertaining to class 3 (high and persistent ICU scores and stressful life-events) as opposed to class 2 (OR = 4.27, p = 0.034) or class 1 (OR = 3.81, p = 0.042). The results suggest the importance of considering callous-unemotional traits and stressful life-events in conjunction. In addition, the genetic variability of OXTR (rs53576) may help to understand individual differences in early development. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/204224https://dx.doi.org/urn:doi:10.1007/s10802-019-00548-zreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PSI2015-63965-RAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-312open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2042242026-06-06T12:50:31Z
dc.title.none.fl_str_mv Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
title Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
spellingShingle Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
Ezpeleta, Lourdes|||0000-0002-8957-083X
Callous-unemotional
Developmental trajectories
Life events
OXTR
Rs53576
title_short Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
title_full Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
title_fullStr Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
title_full_unstemmed Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
title_sort Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
dc.creator.none.fl_str_mv Ezpeleta, Lourdes|||0000-0002-8957-083X
Penelo Werner, Eva|||0000-0001-6796-7660
Osa, Nuria de la|||0000-0003-4499-0942
Navarro, José-Blas|||0000-0001-5929-4224
Fañanás Saura, Lourdes
Fatjó-Vilas, Mar|||0000-0001-9963-6241
author Ezpeleta, Lourdes|||0000-0002-8957-083X
author_facet Ezpeleta, Lourdes|||0000-0002-8957-083X
Penelo Werner, Eva|||0000-0001-6796-7660
Osa, Nuria de la|||0000-0003-4499-0942
Navarro, José-Blas|||0000-0001-5929-4224
Fañanás Saura, Lourdes
Fatjó-Vilas, Mar|||0000-0001-9963-6241
author_role author
author2 Penelo Werner, Eva|||0000-0001-6796-7660
Osa, Nuria de la|||0000-0003-4499-0942
Navarro, José-Blas|||0000-0001-5929-4224
Fañanás Saura, Lourdes
Fatjó-Vilas, Mar|||0000-0001-9963-6241
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Callous-unemotional
Developmental trajectories
Life events
OXTR
Rs53576
topic Callous-unemotional
Developmental trajectories
Life events
OXTR
Rs53576
description The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed yearly from ages 3 to 9 years. Latent class growth analysis for parallel processes was used to identify distinct trajectories for callous-unemotional traits (assessed using the Inventory of Callous-Unemotional Traits, ICU) and number of stressful life-events, and then the influence of being an A allele carrier on class membership was included with OXTR genotypes as a binary time-invariant predictor, following a 3-step approach. A 3-class model showed the highest entropy (.859) and adequate posterior probabilities of class membership (≥.884). Class 1 (n = 226, 59.9%) included children with low and stable ICU scores and low and descending stressful life-events; class 2 (n = 127, 33.7%) included children with high and ascending ICU scores and low and slightly descending stressful life-events; and class 3 (n = 24, 6.4%) included children with persistently high profiles both for ICU scores and stressful life-events. Carrying an A allele (genotypes GA/AA) increased the odds of pertaining to class 3 (high and persistent ICU scores and stressful life-events) as opposed to class 2 (OR = 4.27, p = 0.034) or class 1 (OR = 3.81, p = 0.042). The results suggest the importance of considering callous-unemotional traits and stressful life-events in conjunction. In addition, the genetic variability of OXTR (rs53576) may help to understand individual differences in early development.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/204224
https://dx.doi.org/urn:doi:10.1007/s10802-019-00548-z
url https://ddd.uab.cat/record/204224
https://dx.doi.org/urn:doi:10.1007/s10802-019-00548-z
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PSI2015-63965-R
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-312
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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