Regulation of adaptive tumor immunity by non-coding rnas

Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-codin...

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Detalles Bibliográficos
Autores: Papaioannou, Eleftheria, Prieto-Muñoz, Ana M., González Martín, Alicia, González Molina, María del Pilar, Gámez Reche, Laura
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/717081
Acceso en línea:http://hdl.handle.net/10486/717081
https://dx.doi.org/10.3390/cancers13225651
Access Level:acceso abierto
Palabra clave:cancer immunotherapy
long non-coding RNAs
microRNAs
non-coding RNAs
tumor immunology
Medicina
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spelling Regulation of adaptive tumor immunity by non-coding rnasPapaioannou, EleftheriaPrieto-Muñoz, Ana M.González Martín, AliciaGonzález Molina, María del PilarGámez Reche, Lauracancer immunotherapylong non-coding RNAsmicroRNAsnon-coding RNAstumor immunologyMedicinaCancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapyOur laboratory is funded by grants RTI2018-100008-A-I00 by MCIN/AEI/10.13039/501100011033/ and FEDER “Una manera de hacer Europa”, LAB-AECC 2020 from Spanish Association Against Cancer, SI1-PJI-2019-00241 from Community of Madrid, and merit award RyC-21155 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro” to A.G.-M., E.P. is supported by the FJC2019-040779-I fellowship funded by MCIN/AEI/10.13039/501100011033, L.G.-R. by the PRE2019-087940 fellowship funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”, and M.d.P.G.-M. by a FPI fellowship from Universidad Autónoma de MadridMDPIDepartamento de BioquímicaFacultad de Medicina20212021-11-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/717081https://dx.doi.org/10.3390/cancers13225651reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7170812026-06-23T12:46:27Z
dc.title.none.fl_str_mv Regulation of adaptive tumor immunity by non-coding rnas
title Regulation of adaptive tumor immunity by non-coding rnas
spellingShingle Regulation of adaptive tumor immunity by non-coding rnas
Papaioannou, Eleftheria
cancer immunotherapy
long non-coding RNAs
microRNAs
non-coding RNAs
tumor immunology
Medicina
title_short Regulation of adaptive tumor immunity by non-coding rnas
title_full Regulation of adaptive tumor immunity by non-coding rnas
title_fullStr Regulation of adaptive tumor immunity by non-coding rnas
title_full_unstemmed Regulation of adaptive tumor immunity by non-coding rnas
title_sort Regulation of adaptive tumor immunity by non-coding rnas
dc.creator.none.fl_str_mv Papaioannou, Eleftheria
Prieto-Muñoz, Ana M.
González Martín, Alicia
González Molina, María del Pilar
Gámez Reche, Laura
author Papaioannou, Eleftheria
author_facet Papaioannou, Eleftheria
Prieto-Muñoz, Ana M.
González Martín, Alicia
González Molina, María del Pilar
Gámez Reche, Laura
author_role author
author2 Prieto-Muñoz, Ana M.
González Martín, Alicia
González Molina, María del Pilar
Gámez Reche, Laura
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Bioquímica
Facultad de Medicina
dc.subject.none.fl_str_mv cancer immunotherapy
long non-coding RNAs
microRNAs
non-coding RNAs
tumor immunology
Medicina
topic cancer immunotherapy
long non-coding RNAs
microRNAs
non-coding RNAs
tumor immunology
Medicina
description Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-11-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/717081
https://dx.doi.org/10.3390/cancers13225651
url http://hdl.handle.net/10486/717081
https://dx.doi.org/10.3390/cancers13225651
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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