Spanish consensus on treat to target for osteoporosis

To reach a Spanish expert consensus on a treat-to-target strategy in osteoporosis, a Delphi Consensus Study has been developed. Most of the experts (59.8%) were rheumatologist with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items. Therapeutic objectives,...

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Autores: Nogués, X, Nolla, JM, Casado, E, Jódar, E, Muñoz-Torres, M, Quesada-Gómez, JM, Canals, L, Balcells, M, Lizán, L
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p5899
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/5899
Access Level:acceso abierto
Palabra clave:Management
Osteoporosis
Osteoporosis care
Treatment
Treatment failure
Treat to target
Treat-to-target strategy
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spelling Spanish consensus on treat to target for osteoporosisNogués, XNolla, JMCasado, EJódar, EMuñoz-Torres, MQuesada-Gómez, JMCanals, LBalcells, MLizán, LManagementOsteoporosisOsteoporosis careTreatmentTreatment failureTreat to targetTreat-to-target strategyTo reach a Spanish expert consensus on a treat-to-target strategy in osteoporosis, a Delphi Consensus Study has been developed. Most of the experts (59.8%) were rheumatologist with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items. Therapeutic objectives, patient follow-up scheme, treatment failure criteria, and appropriate treatment choice for use in T2T strategy in Spain have been defined. The paper aims to achieve a Spanish expert consensus on a treat-to-target (T2T) strategy in osteoporosis. A scientific committee led the project and was involved in expert panel identification and Delphi questionnaire development. Two Delphi rounds were completed. The first-round questionnaire included 24 items and assessed, using a seven-point Likert scale, the experts' wish (W) and prognosis (P) in 5 years for each topic (applicability, therapeutic objectives, patient follow-up, and possible treatment to be prescribed). Items for which there was no consensus in the first round were included in the second round. Consensus was defined as >= 75% agreement (somewhat/mostly/entirely agree) or disagreement (somewhat/mostly/entirely disagree) responses. Of the experts, 112 and 106 completed the first and second rounds, respectively. 59.8% were rheumatologists with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items, and was established regarding the utility of a T2T strategy to define therapeutic objectives, optimal follow-up, and therapeutic algorithm. Participants agreed on the utility of the bone mineral density (BMD) value (T-score >-2.5 SD for spine and >-2.5/-2.0 SD for femoral neck), lack of fractures, and fracture risk (FRAX) as therapeutic objectives. For measuring BMD changes, consensus was achieved on the suitability of hip and femoral neck locations. Experts agreed to consider treatment failure as when a significant BMD gain could not be achieved, or when a new fracture occurs within 2-3 years. There was consensus that all proposed therapies should achieve a therapeutic target through T2T strategy (treatments with the highest consensus scores were denosumab and teriparatide). The therapeutic objectives, patient follow-up scheme, treatment failure criteria, and appropriate treatment choice for use in T2T strategy in Spain have been established by a panel of experts. Some aspects nevertheless still require further analysis.SPRINGER LONDON LTD2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5899OSTEOPOROSIS INTERNATIONALISSN: 0937941XISSNe: 14332965reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p58992026-06-21T15:30:37Z
dc.title.none.fl_str_mv Spanish consensus on treat to target for osteoporosis
title Spanish consensus on treat to target for osteoporosis
spellingShingle Spanish consensus on treat to target for osteoporosis
Nogués, X
Management
Osteoporosis
Osteoporosis care
Treatment
Treatment failure
Treat to target
Treat-to-target strategy
title_short Spanish consensus on treat to target for osteoporosis
title_full Spanish consensus on treat to target for osteoporosis
title_fullStr Spanish consensus on treat to target for osteoporosis
title_full_unstemmed Spanish consensus on treat to target for osteoporosis
title_sort Spanish consensus on treat to target for osteoporosis
dc.creator.none.fl_str_mv Nogués, X
Nolla, JM
Casado, E
Jódar, E
Muñoz-Torres, M
Quesada-Gómez, JM
Canals, L
Balcells, M
Lizán, L
author Nogués, X
author_facet Nogués, X
Nolla, JM
Casado, E
Jódar, E
Muñoz-Torres, M
Quesada-Gómez, JM
Canals, L
Balcells, M
Lizán, L
author_role author
author2 Nolla, JM
Casado, E
Jódar, E
Muñoz-Torres, M
Quesada-Gómez, JM
Canals, L
Balcells, M
Lizán, L
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Management
Osteoporosis
Osteoporosis care
Treatment
Treatment failure
Treat to target
Treat-to-target strategy
topic Management
Osteoporosis
Osteoporosis care
Treatment
Treatment failure
Treat to target
Treat-to-target strategy
description To reach a Spanish expert consensus on a treat-to-target strategy in osteoporosis, a Delphi Consensus Study has been developed. Most of the experts (59.8%) were rheumatologist with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items. Therapeutic objectives, patient follow-up scheme, treatment failure criteria, and appropriate treatment choice for use in T2T strategy in Spain have been defined. The paper aims to achieve a Spanish expert consensus on a treat-to-target (T2T) strategy in osteoporosis. A scientific committee led the project and was involved in expert panel identification and Delphi questionnaire development. Two Delphi rounds were completed. The first-round questionnaire included 24 items and assessed, using a seven-point Likert scale, the experts' wish (W) and prognosis (P) in 5 years for each topic (applicability, therapeutic objectives, patient follow-up, and possible treatment to be prescribed). Items for which there was no consensus in the first round were included in the second round. Consensus was defined as >= 75% agreement (somewhat/mostly/entirely agree) or disagreement (somewhat/mostly/entirely disagree) responses. Of the experts, 112 and 106 completed the first and second rounds, respectively. 59.8% were rheumatologists with a mean clinical experience of 21.3 years (SD 8.5). Consensus was achieved for 70% of the items, and was established regarding the utility of a T2T strategy to define therapeutic objectives, optimal follow-up, and therapeutic algorithm. Participants agreed on the utility of the bone mineral density (BMD) value (T-score >-2.5 SD for spine and >-2.5/-2.0 SD for femoral neck), lack of fractures, and fracture risk (FRAX) as therapeutic objectives. For measuring BMD changes, consensus was achieved on the suitability of hip and femoral neck locations. Experts agreed to consider treatment failure as when a significant BMD gain could not be achieved, or when a new fracture occurs within 2-3 years. There was consensus that all proposed therapies should achieve a therapeutic target through T2T strategy (treatments with the highest consensus scores were denosumab and teriparatide). The therapeutic objectives, patient follow-up scheme, treatment failure criteria, and appropriate treatment choice for use in T2T strategy in Spain have been established by a panel of experts. Some aspects nevertheless still require further analysis.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/5899
url https://i3pt.portalinvestigacion.com/publicaciones/5899
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER LONDON LTD
publisher.none.fl_str_mv SPRINGER LONDON LTD
dc.source.none.fl_str_mv OSTEOPOROSIS INTERNATIONAL
ISSN: 0937941X
ISSNe: 14332965
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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