Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose

Hydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the disease...

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Autores: Solé Martí, Xavier|||0000-0002-5544-2485, Vilella, Tània, Labay, Cédric Pierre|||0000-0001-5147-5100, Tampieri, Francesco|||0000-0003-1474-867X, Ginebra Molins, Maria Pau|||0000-0002-4700-5621, Canal Barnils, Cristina|||0000-0002-3039-7462
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/370565
Acceso en línea:https://hdl.handle.net/2117/370565
https://dx.doi.org/10.1039/D2BM00308B
Access Level:acceso abierto
Palabra clave:Biomedical materials
Cancer--Research
Materials biomèdics
Càncer--Investigació
Àrees temàtiques de la UPC::Enginyeria dels materials
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spelling Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcelluloseSolé Martí, Xavier|||0000-0002-5544-2485Vilella, TàniaLabay, Cédric Pierre|||0000-0001-5147-5100Tampieri, Francesco|||0000-0003-1474-867XGinebra Molins, Maria Pau|||0000-0002-4700-5621Canal Barnils, Cristina|||0000-0002-3039-7462Biomedical materialsCancer--ResearchMaterials biomèdicsCàncer--InvestigacióÀrees temàtiques de la UPC::Enginyeria dels materialsHydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the diseased site, plasma-treated hydrogels can overcome some of the limitations presented by plasma-treated liquids in in vivo therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.Peer ReviewedRoyal Society of Chemistry (RSC)20222022-06-0920222022-07-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/370565https://dx.doi.org/10.1039/D2BM00308Breponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 714793 Atmospheric Pressure plAsma meets biomaterials for bone Cancer HEalingopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3705652026-05-27T15:37:01Z
dc.title.none.fl_str_mv Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
spellingShingle Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
Solé Martí, Xavier|||0000-0002-5544-2485
Biomedical materials
Cancer--Research
Materials biomèdics
Càncer--Investigació
Àrees temàtiques de la UPC::Enginyeria dels materials
title_short Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_full Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_fullStr Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_full_unstemmed Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_sort Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
dc.creator.none.fl_str_mv Solé Martí, Xavier|||0000-0002-5544-2485
Vilella, Tània
Labay, Cédric Pierre|||0000-0001-5147-5100
Tampieri, Francesco|||0000-0003-1474-867X
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Canal Barnils, Cristina|||0000-0002-3039-7462
author Solé Martí, Xavier|||0000-0002-5544-2485
author_facet Solé Martí, Xavier|||0000-0002-5544-2485
Vilella, Tània
Labay, Cédric Pierre|||0000-0001-5147-5100
Tampieri, Francesco|||0000-0003-1474-867X
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Canal Barnils, Cristina|||0000-0002-3039-7462
author_role author
author2 Vilella, Tània
Labay, Cédric Pierre|||0000-0001-5147-5100
Tampieri, Francesco|||0000-0003-1474-867X
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Canal Barnils, Cristina|||0000-0002-3039-7462
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biomedical materials
Cancer--Research
Materials biomèdics
Càncer--Investigació
Àrees temàtiques de la UPC::Enginyeria dels materials
topic Biomedical materials
Cancer--Research
Materials biomèdics
Càncer--Investigació
Àrees temàtiques de la UPC::Enginyeria dels materials
description Hydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the diseased site, plasma-treated hydrogels can overcome some of the limitations presented by plasma-treated liquids in in vivo therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-06-09
2022
2022-07-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/370565
https://dx.doi.org/10.1039/D2BM00308B
url https://hdl.handle.net/2117/370565
https://dx.doi.org/10.1039/D2BM00308B
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 714793 Atmospheric Pressure plAsma meets biomaterials for bone Cancer HEaling
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
publisher.none.fl_str_mv Royal Society of Chemistry (RSC)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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