Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases

5 páginas.-- El documento en word es la versión post-print.

Detalles Bibliográficos
Autores: Rivard, Alain, Andrés, Vicente
Tipo de recurso: artículo
Fecha de publicación:2000
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/36836
Acceso en línea:http://hdl.handle.net/10261/36836
Access Level:acceso abierto
Palabra clave:Smooth muscle cell
Cell cycle
Atherosclerosis
Restenosis
Gene therapy
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spelling Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseasesRivard, AlainAndrés, VicenteSmooth muscle cellCell cycleAtherosclerosisRestenosisGene therapy5 páginas.-- El documento en word es la versión post-print.Atherosclerosis is the principal cause of myocardial infarction, stroke, and peripheral vascular disease, accounting for nearly half of all mortality in developed countries. For example, it has been estimated that atherosclerosis leads to approximately 500,000 deaths from coronary artery disease and 150,000 deaths from stroke every year in the United States (American Heart Association, 1996). Percutaneous transluminal angioplasty has become a well-established technique for revascularization of occluded arteries. However, the long-term efficacy of the procedure remains limited by progressive vessel renarrowing (restenosis) within the following few months after angioplasty. Abnormal vascular smooth muscle cell (VSMC) proliferation is thought to play an important role in the pathogenesis of both atherosclerosis and restenosis. Accordingly, considerable effort has been devoted to elucidate the mechanisms that regulate cell cycle progression in VSMCs. In the present article, we will review the different factors that are involved in the control of VSMC proliferation, especially in the context of cardiovascular disease. Ultimately, a thorough understanding of these regulatory networks may lead to the development of novel drug and gene therapies for the treatment of cardiovascular diseases. Therapeutic approaches that targeted specific cell-cycle control genes or growth regulatory molecules which effectively inhibited neointimal lesion formation will be also discussed.Peer reviewedHistology and Histopathology201120112000info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/36836reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://www.hh.um.es/Abstracts/Vol_15/15_2/15_2_27.htminfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/368362026-05-22T06:33:51Z
dc.title.none.fl_str_mv Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
title Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
spellingShingle Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
Rivard, Alain
Smooth muscle cell
Cell cycle
Atherosclerosis
Restenosis
Gene therapy
title_short Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
title_full Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
title_fullStr Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
title_full_unstemmed Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
title_sort Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
dc.creator.none.fl_str_mv Rivard, Alain
Andrés, Vicente
author Rivard, Alain
author_facet Rivard, Alain
Andrés, Vicente
author_role author
author2 Andrés, Vicente
author2_role author
dc.subject.none.fl_str_mv Smooth muscle cell
Cell cycle
Atherosclerosis
Restenosis
Gene therapy
topic Smooth muscle cell
Cell cycle
Atherosclerosis
Restenosis
Gene therapy
description 5 páginas.-- El documento en word es la versión post-print.
publishDate 2000
dc.date.none.fl_str_mv 2000
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/36836
url http://hdl.handle.net/10261/36836
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.hh.um.es/Abstracts/Vol_15/15_2/15_2_27.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Histology and Histopathology
publisher.none.fl_str_mv Histology and Histopathology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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