Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans

Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports est...

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Autores: Fagundo, Ana B., Torre Fornell, Rafael de la, Jiménez Murcia, Susana, Agüera, Zaida, Pastor, Antonio, Casanueva, Felipe F., Granero, Roser, Baños, Rosa M., Botella, Cristina, de Pino Gutiárrez, Amparo, Fernández Real, Jose M., Fernández García, José C., Frühbeck, Gema, Gómez Ambrosi, Javier, Menchón, José M., Moragrega, Inés, Rodríguez, Roser, Tárrega, Salomé, Tinahones Madueño, Francisco José, Fernández Aranda, Fernando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/23574
Acceso en línea:http://hdl.handle.net/10230/23574
http://dx.doi.org/10.1371/journal.pone.0066387
Access Level:acceso abierto
Palabra clave:Cannabinoides -- Efectes fisiològics
Cannabinoides -- Receptors
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spelling Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humansFagundo, Ana B.Torre Fornell, Rafael de laJiménez Murcia, SusanaAgüera, ZaidaPastor, AntonioCasanueva, Felipe F.Granero, RoserBaños, Rosa M.Botella, Cristinade Pino Gutiárrez, AmparoFernández Real, Jose M.Fernández García, José C.Frühbeck, GemaGómez Ambrosi, JavierMenchón, José M.Moragrega, InésRodríguez, RoserTárrega, SaloméTinahones Madueño, Francisco JoséFernández Aranda, FernandoCannabinoides -- Efectes fisiològicsCannabinoides -- ReceptorsAnimal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.Financial support was received from Fondo de Investigación Sanitaria - FIS (PI081714; PI11/210) and AGAUR (2009SGR1554, 2009SGR718). Ministerio de Ciencia e Innovación Subprograma Juan de la Cierva (JCI-2011-09248). CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and CIBER Salud Mental (CIBERsam), are an initiative of ISCIIPublic Library of Science (PLoS)201520152013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23574http://dx.doi.org/10.1371/journal.pone.0066387reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésPLoS ONE. 2013;8(6):e66387info:eu-repo/grantAgreement/ES/3PN/JCI2011-09248© 2013 Fagundo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/235742026-06-12T07:21:37Z
dc.title.none.fl_str_mv Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
title Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
spellingShingle Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
Fagundo, Ana B.
Cannabinoides -- Efectes fisiològics
Cannabinoides -- Receptors
title_short Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
title_full Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
title_fullStr Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
title_full_unstemmed Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
title_sort Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans
dc.creator.none.fl_str_mv Fagundo, Ana B.
Torre Fornell, Rafael de la
Jiménez Murcia, Susana
Agüera, Zaida
Pastor, Antonio
Casanueva, Felipe F.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
de Pino Gutiárrez, Amparo
Fernández Real, Jose M.
Fernández García, José C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón, José M.
Moragrega, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones Madueño, Francisco José
Fernández Aranda, Fernando
author Fagundo, Ana B.
author_facet Fagundo, Ana B.
Torre Fornell, Rafael de la
Jiménez Murcia, Susana
Agüera, Zaida
Pastor, Antonio
Casanueva, Felipe F.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
de Pino Gutiárrez, Amparo
Fernández Real, Jose M.
Fernández García, José C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón, José M.
Moragrega, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones Madueño, Francisco José
Fernández Aranda, Fernando
author_role author
author2 Torre Fornell, Rafael de la
Jiménez Murcia, Susana
Agüera, Zaida
Pastor, Antonio
Casanueva, Felipe F.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
de Pino Gutiárrez, Amparo
Fernández Real, Jose M.
Fernández García, José C.
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón, José M.
Moragrega, Inés
Rodríguez, Roser
Tárrega, Salomé
Tinahones Madueño, Francisco José
Fernández Aranda, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cannabinoides -- Efectes fisiològics
Cannabinoides -- Receptors
topic Cannabinoides -- Efectes fisiològics
Cannabinoides -- Receptors
description Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23574
http://dx.doi.org/10.1371/journal.pone.0066387
url http://hdl.handle.net/10230/23574
http://dx.doi.org/10.1371/journal.pone.0066387
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS ONE. 2013;8(6):e66387
info:eu-repo/grantAgreement/ES/3PN/JCI2011-09248
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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